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National Cancer Institute - U.S. National Institutes of Health - www.cancer.gov

Clinical Trials by Cancer Site

Skin Cancer/Melanoma

The most common forms of skin cancers are basal cell and squamous cell carcinomas, and the most serious form is melanoma, which can present itself as cutaneous, ocular, or mucosal melanoma. It is a disease that is most frequently diagnosed in Caucasians, who are at greater risk than any other race. Risk factors vary for different types of skin, but have been associated with age, prior history, basal cell or squamous cell skin cancers, family history, sun sensitivity, overexposure to the sun, and work-related exposure to coal, tar, pitch, creosote, arsenic compounds, or radium.

Treatment options may vary depending on the type of melanoma, stage of the disease, patient's age, and other medical conditions, and should be discussed with the patient's physician.

Melanoma Clinical Trials

The Center for Cancer Research (CCR), NCI's largest division doing research on campus, conducts melanoma clinical trials at the NIH Clinical Center in Bethesda, Md. NCI accepts referrals to melanoma clinical trials conducted in Bethesda, Md., through its Clinical Trials Referral Office (formerly called Clinical Studies Support Center) at 1-888-NCI-1937 (1-888-624-1937).

NCI is currently conducting the following trials for patients with melanoma. Click on the trials below for additional details, including a summary of eligibility criteria, treatment plan, and information on how to contact the principal investigators and their staff directly.


  
Trial and Protocol Number
Melanoma
Phase III
A Random-Assignment Study of Hepatic Arterial Infusion of Melphalan With Venous Filtration via Peripheral Hepatic Perfusion (PHP0 (Delcath System) Versus Best Alternative Care for Ocular and Cutaneous Melanoma Metastatic to the Liver
NCI-06-C-0088

Principal Investigator:Referral Contact:
Marybeth S. HughesCarole Webb
301-594-9341301-451-6940
Webbcc@mail.nih.gov
Phase II
Phase II Study of Metastatic Melanoma Using a Chemoradiation Lymphodepleting Conditioning Regimen Followed by Infusion of Anti-Mart-1 and Anti-gp100 TCR-Gene Engineered Lymphocytes and Peptide Vaccines
NCI-09-C-0051

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Phase II Study in Patients With Metastatic Melanoma Using a Non-Myeloablative Lymphocyte Depleting Regimen of Chemotherapy Followed by Infusion of Tumor Reactive Peripheral Blood Lymphocytes (PBL) and High or Low Dose Aldesleukin
NCI-08-C-0104

Principal Investigator:Referral Contact:
Udai KammulaLinda Williams
301-435-86061-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Phase I
A Phase I Study of the Safety and Efficacy of GC1008: A Human Anti-Transforming Growth Factor-beta (TGF-β) Monoclonal Antibody in Patients With Advanced Renal Cell Carcinoma or Malignant Melanoma
NCI-06-C-0200

Principal Investigator:Referral Contact:
John C. MorrisBrenda Roberson
301-402-2912301-435-4733
broberson@mail.nih.gov


  
Trial and Protocol Number
Melanoma, Skin
Phase II
Transfer of Autologous T Cells Transduced With the Anti-MART-1 F5 T Cell Receptor in High Risk Melanoma
NCI-08-C-0162

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Phase II Study of Metastatic Melanoma Using Lymphodepleting Conditioning Followed by Infusion of Anti-MART-1 F5 TCR-Gene Engineered Lymphocytes and ALVAC Virus Immunization
NCI-08-C-0056

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Phase II Study of Metastatic Melanoma Using Lymphodepleting Conditioning Followed by Infusion of Anti-gp100:154-162 TCR-Gene Engineered Lymphocytes and ALVAC Virus Immunization
NCI-08-C-0055

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Phase II Study Using Short-Term Cultured Anti-Tumor Autologous Lymphocytes Following a Non-Myeloablative Lymphocyte Depleting Chemotherapy Regimen in Metastatic Melanoma
NCI-07-C-0176

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Phase II Study of Metastatic Melanoma Using Lymphodepleting Conditioning Followed by Infusion of Anti-MART-1 F5 TCR-Gene Engineered Lymphocytes
NCI-07-C-0175

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Phase II Study of Metastatic Melanoma Using Lymphodepleting Conditioning Followed by Infusion of Anti-gp100: 154:162 TCR Gene Engineered Lymphocytes
NCI-07-C-0174

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Evaluation of the Impact of Adjuvants Accompanying Peptide Immunization in High Risk Melanoma
NCI-06-C-0069

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Treatment of Patients With Metastatic Melanoma Using Cloned Lymphocytes Following Administration of a Non-Myeloablative but Lymphocyte Depleting Regimen
NCI-99-C-0158

Principal Investigator:Referral Contact:
Steven A. RosenbergJune A. Kryk
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Phase I/II
Phase I/II Study Using a Non-Myeloablative Lymphocyte Depleting Regimen of Chemotherapy Followed by Infusion of Allogeneic Tumor-Reactive Lymphocyte Cell Line DMF5 in Metastatic Melanoma
NCI-07-C-0210

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Phase I
A Phase I Study of Subcutaneous "CYT 107" (Interleukin-7) in Refractory Metastatic Melanoma or Renal Cell Carcinoma
NCI-07-C-0114

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
No Phase
Dermoscopic Diagnosis, Histopathological Correlation, and Cellular Immortalization of Melanocytic Nevi and Primary Cutaneous Melanoma
NCI-06-C-0060

Principal Investigator:Referral Contact:
Thomas HornyakSusan Booher
301-451-1926301-402-1474
boohers@mail.nih.gov


  
Trial and Protocol Number
Solid Tumor (Adult)
Phase II
Phase II Study of Metastatic Cancer That Overexpresses p53 Using Lymphodepleting Conditioning Followed by Infusion of Anti-p53 TCR-Gene Engineered Lymphocytes and Dendritic Cell Vaccination
NCI-08-C-0155

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Phase II Study of Metastatic Cancer That Expresses NY-ESO-1 Using Lymphodepleting Conditioning Followed by Infusion of Anti-NY ESO-1 TCR-Gene Engineered Lymphocytes
NCI-08-C-0121

Principal Investigator:Referral Contact:
Steven A. RosenbergLinda Williams
1-866-820-4505
(Toll Free)
1-866-820-4505
(Toll Free)
ncisbirc@mail.nih.gov
Phase I
A Phase I Study of Dasatinib in Combination With Bevacizumab in Advanced Solid Tumors
NCI-09-C-0019

Principal Investigator:Referral Contact:
Elise C. KohnLaura D. Otten
301-402-2726301-451-1228
1-866-611-6310 (Toll Free)
ottenl@mail.nih.gov


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