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Melanoma, Skin

Dermoscopic Diagnosis, Histopathological Correlation, and Cellular Immortalization of Melanocytic Nevi and Primary Cutaneous Melanoma

NCI-06-C-0060                                                                                      Print this page 


Investigator(s):

Thomas Hornyak, M.D., Ph.D.
Principal Investigator
Phone: 301-451-1926

Referral Contact(s):

Susan Booher, M.S., R.N.
Research Nurse
Phone: 301-402-1474
boohers@mail.nih.gov

 

Primary Eligibility:

  • Infants/Children (≥ 5 years)
    • Large congenital melanocytic nervus (LCMN, diagnosed clinically or by biopsy) that is greater than 20 cm in any one dimension or that is greater than 8 cm in any one dimension involving the scalp
  • Adults (≥ 18 years)
    • 100 or more melanocytic nevi greater than 2 mm in diameter, one melanocytic nevus greater than or equal to 4 mm in longest dimension; can have prior history of cutaneous or ocular malignant melanoma

      • OR
    • Current pigmented lesion clinically suspicious for primary melanoma
  • Must have outside referring physician
  • All patients, or their parents or legal guardians, must be able to understand and sign an informed consent
  • No diagnosis of genetic syndrome associated with multiple lentigines or nevi (Peutz-Jeghers syndrome, Carney complex, Turner syndrome, Noonan syndrome)
  • No two or more first-degree relatives with history of cutaneous melanoma or familial atypical mole-melanoma syndrome
  • No diagnosis of cancer-associated syndromes (xeroderma pigmentosum, type I neurofibromatosis, Li-Fraumeni syndrome)
  • Able to tolerate surgical procedures
  • No bleeding diathesis, coagulopathy, or excessive bleeding tendency
  • Patient must be willing to under go an elective biopsy of a melanocytic nevus

      • Treatment Plan:

      • Patients' personal and family health histories are obtained
      • Patients are examined by an investigative team of doctors
      • Photographs of part or all of the skin surface will be taken and several lesions will be examined with a dermatoscope
      • Clinically important skin lesions may be biopsied
      • Additional tests or examinations may be recommended
      • Patients are followed periodically for skin or physical examinations, photography, laboratory and imaging evaluations, and possible skin biopsies
      • Children may undergo brain magnetic resonance imaging (MRI) depending on the results of the child’s clinical examination

      Additional Information:

      • This trial will be conducted at the NIH Clinical Center in Bethesda, MD. It is open to patients who meet the eligibility requirements, regardless of where they live in the United States.
      • There is no charge for medical care received at NIH Clinical Center.
      • PDQ (Physicians Data Query) - provides additional details about this study for health care providers.
        •


      Reviewed: 12/4/08
      Updated: 10/14/08

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