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Frontiers in Population Genomics Research Meeting
Frontiers in Population Genomics Research Meeting was held December 18-19, 2007, at the Bethesda North Marriott Hotel & Conference Center in Bethesda, Md.
Agenda and Slide Presentations
All slide presentations linked from the speaker's name are in pdf format. To view these PDFs you will need Adobe Reader.
8:30 a.m. |
Introductions, Welcome and Charge Greg Burke and Jeff Murray
Overview of the Office of Polpulation Genomics (OPG) |
9:00 a.m. |
History and Need Francis Collins |
9:30 a.m. |
Mission, Goals and Accomplishments Teri Manolio |
10:00 a.m. |
Discussion |
10:30 a.m. |
Break and Resources |
11:00 a.m. |
Large Cohort Studies Greg Burke, Barbara Koenig, Rex Chisholm
- Gaps in current portfolio of population studies
- Facilitating use of existing population studies for genomic research
- Advantages of longitudinal studies for genetic research
- Community consultation
- Adequacy of consent for genomic research and data sharing
- Efficient methods of collecting phenotype and exposure data (electronic health records, other information systems)
- Research in clinical care systems or small clinical practices
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11:25 a.m. |
General Discussion Working Group |
12:20 p.m. |
Summary of Possible Activities and Priorities for NHGRI/OPG Working Group
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12:30 p.m. |
Lunch |
1:30 p.m. |
Building on Genome-Wide Association (GWA) Studies Jeff Murray
- Additional GWA studies needed
- Preparing for next population-based technologies
- Mining GWA data, pooling and establishing collaborations
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1:40 p.m. |
Assigned Discussants David Goldstein and Malcolm Pike
- Followup of GWA findings
- GWA studies of risk factors
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1:50 p.m. |
General Discussion Working Group |
2:20 p.m. |
Summary of Possible Activities and Priorities for NHGRI/OPG |
2:30 p.m. |
Genomic Technologies Suitable for Population Studies
Mike Snyder
- Technologies ready or nearly ready for application to large populations
- Elements of genome to be assessed (gene expression, epigenetics, transcription factor binding, structural variants)
- Applying ENCODE information
- Future technology directions
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2:40 p.m. |
Genomic Technologies Suitable for Population Studies
Stephen Chanock and Mike Snyder
- Sample Collection
- Investigating causality
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2:50 p.m. |
General Discussion Working Group |
3:20 p.m. |
Summary of Possible Activities and Priorities for NHGRI/OPG Working Group
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3:30 p.m. |
Break |
4:00 p.m. |
Databases
Jim Ostell
- dbGaP-NHGRI role in development and management
- Integration with sequencing data and other technologies
- Interacting with "parent" databases-at what point are data shared publicly?
- Sharing across databases: technical, legal, and policy issues
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4:10 p.m. |
Assigned Discussants: Chris Chute and Lon Cardon-
Harmonizing phenotypes and environmental exposures
- Minimal dataset for deposition needed to accurately reflect association findings
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4:20 p.m. |
Working Group |
4:50 p.m.
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Summary of Possible Activities and Priorities for NHGRI/OPG Working Group |
5:00 p.m. |
Data Analysis Lon Cardon
- Developing new statistical methods
- Facilitating cross-study analyses of heterogeneous populations
- Building analytic capacity outside NHGRI: computing infrastructure, training
- Building analytic capacity inside NHGRI: analysis roles for OPG staff
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5:10 p.m. |
Assigned Discussants Marcella Devoto and Ellen Wijsman
- Quantitative traits
- Gene-environment interactions
- Statistical issues in selecting appropriate study designs
- Training of statistical geneticists
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5:20 p.m. |
General Discussion Working Group |
5:50 p.m. |
Summary of Possible Activities and Priorities for NHGRI/OPG Working Group |
6:00 p.m. |
Adjournment |
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8:30 a.m. |
Health and Health Disparities of U.S. Race/Ethnic Minority Populations Richard Cooper
- What's likely to be genetic, and what isn't, in minority health disparities
- Dealing with real biologic differences in genetically defined risk (major allele frequency differences, etc.)
- Barriers to application of findings in minority populations: access to care, fear of genetic testing, stigmatization
- Accommodating diverse ancestral origins in interpretation of findings (AIMs vs. selfidentified race)
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8:40 a.m. |
Assigned Discussants Martha Daviglus and Charles Rotimi
- Unique genetic research issues among specific race/ethnic minorities
- Working with indigenous populations in general, and what should be our engagement with Africa?
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8:50 a.m. |
General Discussion Working Group |
9:20 a.m. |
Summary of Possible Activities and Priorities for NHGRI/OPG
Working Group |
9:30 a.m. |
Novel Population Research Approaches Howard MacLeod, Montse Garcia-Closas and Anne Newman
- Gaps in current portfolio of population studies
- Pharmacogenetics
- Molecular taxonomy of disease
- Genes predicting good health and function
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9:50 a.m. |
General Discussion Working Group |
10:20 a.m. |
Summary of Possible Activities and Priorities for NHGRI/OPG Working Group
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10:30 a.m. |
Break |
11:00 a.m. |
Clinical Translation
Bob Nussbaum
- Use of genetic testing in clinical care
- Direct to consumer genetic testing (23andMe, etc.)
- Use of electronic medical records in genetic research and in clinical application of actionable findings
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11:10 a.m. |
Assigned Discussants Joe McInerney and David Schwartz
- Education of, and communication of actionable findings to, lay/clinical communities
- Improving research access to, and quality of, phenotyping information collected in clinical care
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11:20 a.m. |
General Discussion Working Group |
11:50 a.m. |
Summary of Possible Activities and Priorities for NHGRI/OPG Working Group |
12:00 p.m. |
Break to Distribute Box Lunches
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12:15 p.m. |
Cross-Disciplinary Training
Tom Pearson
- Genetics to epidemiologists
- Epidemiology to geneticists (including bench scientists)
- Fostering young investigators
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12:25 p.m. |
Assigned Discussants
Richard Cooper and Ellen Wijsman
- The role of multidisciplinary training vs. multidisciplinary teams
- Balancing training to match the scientific goals: Is this population science or genetics?
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12:35 p.m. |
General Discusssion Working Group
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1:05 p.m. |
Summary of possible activities and priorities for NHGRI/OPG
Working Group
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1:15 p.m. |
Conclusions, Priorities, and Recommendations
Greg Burke and Jeff Murray
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2:00 p.m. |
Adjournment |
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Last Reviewed: July 12, 2008
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