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Molecular Targets Development Program |
Selected Bibliography of MTDP Scientists, 2000-2006 2000 |
2001 | 2002 | 2003 | 2004 | 2005
| 2006 |
2007 | In Press Meragelman, T. L.; Willis, R. H.; Woldemichael, G. M.; Heaton, A.; Murphy, P. T.; Snader, K. M.; Newman, D. J.; Soest, R. V.; Boyd, M. R.; Ii, J. H. and McKee, T. C.: Candidaspongiolides, distinctive analogues of tedanolide from sponges of the genus Candidaspongia. J. Nat. Prod. (2007). Newman, D. J.; Cragg, G. M. and O'Keefe, B. R.: Biopharmaceutical drugs from natural sources. Modern Biopharmaceuticals. J. Knablein, R. H. Muller Eds., Wiley-VCH Verlag GmbH & Col. Marchand, C.; Beutler, J. A.; Wamiur, A.; Budihas, S. R.; Mollmann, U.; Heinisch, L.; Mellors, J. W.; LeGrice, S. F. and Pommier, Y.: Madurahydroxylactone derivatives as dual inhibitors of HIV-1 integrase and RNase H. Antimicrob. Agents Chemother. 52 (1): 361-364. 2008. Dat, N. T.; Bae, K. H.; Wamiru, A.; McMahon, J. B.; Le Grice, S. F. J.; Bona, M.; Beutler, J. A. and Kim, Y. H.: A dimeric lactone, from Ardisia Japonica which inhibits HIV-1 and HIV-2 ribonuclease H. J. Nat. Prod. 70 (5): 839-841, 2007. Fromme, R.; Katilene, Z.; Giomarelli, B.; Bogani, G.; McMahon, J.; Mori, T.; Fromme, P. and Ghirlanda, G.: A novel mutant cyanovirin-N provides insight into the role of multivalent interactions with gp120 for antiviral activity. Biochemistry. 46: 9199-9207, 2007. Giomarelli, B.; Washington, A. V.; Chisholm, M. M.; Quigley, L.; McMahon, J. B.; Mori, T. and McVicar, D. W.: Inhibition of thrombin-induced platelet aggregation using human single chain Fv antibodies specific for TREM-like transcript-1. Thrombosis and Haemostasis. 97: 955-963. 2007. Henrich, C. J.; Goncharova, E. I.; Wilson, J. A.; Gardella, R. S.; Johnson, T. R.; McMahon, J. B.; Takada, K.; Bokesch, H. R. and Gustafson, K. R.: Natural products active in aberrant c-Kit signaling. Chemical Biology & Drug Design. 69: 321-330, 2007. Henrich, C. J.; Robey, R. W.; Bokesch, H. R.; Bates, S. E.; Shukla, S.; Ambudkar, S. V.; Dean, M. and McMahon, J. B.: New inhibitors of ABCG2 identified by high-throughput screening. Mol. Cancer Ther. 6(12):3271-3278, 2007. Krumpe, L. R. H. and Mori, T.: Potential of peptide library technology to identify functional targeting peptides. Expert Opinion on Drug Discovery. 2: 525-537, 2007. McFeeters, R. L.; Xiong, C.; O'Keefe, B. R.; Bokesch, H. R.; McMahon, J. B.; Ratner, D. M.; Castelli, R.; Seeberger, P. H. and Byrd, R. A.: The novel fold of scytovirin reveals a new twist for antiviral entry inhibitors. J. Mol. Biol. 369 (2): 451-461, 2007. Mente, N.; Wiemer, A. J.; Neighbors, J. A.; Beutler, J. A.; Hohl, R. J.; and Wiemer, D. F.: Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series. Bioorg. Med. Chem. Lett. 17: 911-915, 2007. Ruocco, K. M.; Goncharova, E. l.; Young, M. R.; Colburn, N. H., McMahon, J. B. and Henrich, C. J.: A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1. J. Biomol. Screen. 12 (1):133-139, 2007.Yang, Y.; Kitagaki, J.; Dai, R. M.; Tsai, Y. C.; Lorick, K. L.; Ludwig, R. L.; Yang, Y.; Kitagaki, J.; Dai, R. M.; Tsai, Y. C.; Lorick, K. L.; Ludwig, R. L.; Pierre, S. A.; Jensen, J. P.; Davydov, I. V.; Oberoi, P.; Li, C. C.; Kenten, J. H.; Beutler, J. A.; Vousden, K. H. and Weissman, A. M.: Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res. 67: (19): 9472-9481, 2007. Ziolkowska, N. E.; Shenoy, S. R.; O'Keefe, B. R.; McMahon, J. B.; Palmer, K. E.; Dwek, R. A.; Wormald, M. R. and Wlodawer, A. Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin. Proteins 67: (3):661-670, 2007. Beutler, J. A.; Jato, J.; Cragg, G. M.; Wiemer, D. F.; Neighbors, J. D.; Salnikova, M. S.; Hollingshead, M. G.; Scudiero, D. and McCloud, T. G.: The schweinfurthins: Issues in development of a plant-based anticancer lead. In: Bogers, R. In Medicinal and Aromatic Plants. Agricultural, Commercial, Ecological, Legal, Pharmacological and Social Aspects. Vol. 17. Dordrecht: Springer; 2006 p. 301-309. Giomarelli, B.; Schumacher, K. M.; Taylor, T. E.; Sowder II, R. C.; Hartley, J. L.; McMahon, J. B. and Mori, T.: Recombinant production of anti-HIV protein griffithsin, by auto-induction in a fermentor culture. Prot. Exp. Pur. 14: 194-202, 2006. Helle, F.; Wychowski, C.; Vu-Dac, N.; Gustafson, K. R.; Voisset, C. and Dubuisson, J. Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycans. J. Biol. Chem. 281 35: 25177-25183, 2006. Henrich, C. J.; Bokesch, H. R.; Dean, M.; Bates, S. E.; Robey, R. W.; Goncharova, E. I.; Wilson, J. A. and McMahon, J. B. A high-throughput cell-based assay for inhibitors of ABCG2 activity. J. Biomol. Screen. 11: 176-183, 2006. Kim, Y. H.; Park, E. J.; Park, M. H.; Badarch, U.; Woldemichael, G. and Beutler J. A.: Crinamine from Crinum asiaticum var. japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2. Biol. Pharm. Bull. 29(10): 2140-2142, 2006. Krumpe, L. R. H. and Mori, T.: The use of phage-displayed peptide libraries to develop tumor-targeting drugs. Int. J. Pept. Res. Ther. 12: 79-91, 2006. Krumpe, L. R. H.; Atkinson, A. J.; Smythers, G. W.; Kandel, A.; Schumacher, K. M.; McMahon, J. B.; Makowski, L. and Mori, T.: T7 lytic phage-displayed peptide libraries exhibit less sequence bias than M13 filamentous phage-displayed peptide libraries. Proteomics. 6: 4210-4222, 2006. Liang, M. C.; Bardhan, S.; Pace, E.A.; Rosman, D.; Beutler, J. A.; Porco, Jr., J. A. and Gilmore, T. D. Inhibition of transcription factor NF-қB signaling proteins IKKβ and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity. Biochem. Pharmacol. 71: 634-645, 2006. Martinez, E. D.; Dull, A. B.; Beutler, J. A. and Hager, G. L.: High-content fluorescence-based screening for epigenetic modulators. Methods Enyzmol. 414: 21-36, 2006. Neighbors, J. D.; Salnikova, M. S.; Beutler, J. A. and Wiemer, D. F.: Synthesis and structure activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity. Bioorg. Med. Chem. 14: 1771-1784, 2006. Sakamoto, K.; Ito, Y.; Mori, T. and Sugimura, K.: Interaction of human lactoferrin with cell adhesion molecules through RGD motif elucidated by lactoferrin-binding epitopes. J. Biol. Chem. 281: 24472-24478, 2006. Woldemichael, G. M.; Vasselli, J. R.; Gardella, R. S.; McKee, T. C.; Linehan, W. M. and McMahon, J. B.: Development of a cell-based reporter assay for screening of inhibitors of hypoxia-inducible factor 2-induced gene expression. J. Biomol. Screen. 11 (6): 678-687, 2006. Xiong, C.; O'Keefe, B. R.; Byrd, R. A. and McMahon, J. B.: Potent anti-HIV activity of scytovirin domain 1 peptide. Peptides. 27(7): 1668-1675, 2006. Xiong, C. Y.; O'Keefe, B. R.; Botos, I.; Wlodawer, A. and McMahon, J. B: Overexpression and purification of scytovirin, a potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Prot. Exp. Pur. 46(2): 233-239, 2006. Ziolkowska, N. E.; O'Keefe, B. R.; Mori, T.; Zhu, C.; Giomarelli, B.; Vojdani, D.; Palmer, K. E.; McMahon, J. B. and Wlodawer, A. Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding. Structure. 14(7): 1127-1135, 2006. Budihas, S. R.; Gorshkova, I. I.; Gaidamakov, S. A.; Wamiru, A.; Bona, M. K.; Parniak, M. A.; Crouch, R. C.; McMahon, J. B.; Beutler, J. A. and LeGrice, S. F. J. Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones. Nucl. Acids Res. 33(4): 1249-1256, 2005. Abstract PubMed Calis, I.; Kirmizibekmez, H.; Beutler, J. A.; Dönmez, F. N.; Yalcin, E.; Kilic, M.; Özalp, M..; Rüedi, P. and Tasdemir, D.: Secondary metabolites of Phlomis viscosa and their biological activities. Turkish J. Chem. 29(1): 71-81, 2005. Full text Chen, B.; Colgrave, M. L.; Daly, N. L.; Rosengren, K. J.; Gustafson, K. R.; Craik, D. J. Isolation and characterization of novel cyclotides from Viola hederaceae. J. Biol. Chem. 280: 22395-22405, 2005. PubMed Dijoux, M.-G., Schnabel, P.C., Hallock, Y.F., Boswell, J.L., Johnson, T.R., Wilson, J.A., Ireland, C.M., Van Soest, R.W.M., Boyd, M.R., Barrows, L.R. and Cardellina, J.H. II. Antitumor activity and distribution of pyrroloiminoquinones in the sponge genus Zyzzya. Bioorg.Med.Chem. 13: 6035-6044, 2005. Abstract PubMed Koltay, F.; Daly, N. L.; Gustafson, K. R.; Craik, D. J. Structure of circulin B and implications for antimicrobial activity of the cyclotides. Int. J. Peptide Res. Therapeut. 11: 51-58, 2005. PubMed Martinez, E. D.; Rayasam, G. V.; Dull, A. B.; Walker, D. A. and Hager, G. L.: An estrogen receptor chimera senses ligands by nuclear translocation. J. Steroid Biochem. Mol. Biol. 97(4): 307-321, 2005. McMahon, J. B.; Gustafson, K. R. and Henrich, C. J.: Molecular-targeted drug screening at the NCI Center for Cancer Research. AACR Education Book. 125-129, 2005. Mori, T.; O'Keefe, B. R.; Sowder II, R. C.; Bringans, S.; Gardella, R.; Berg, S.; Cochran, P.; Turpin, J. A.; Buckheit Jr, R. W.; McMahon, J. B. and Boyd, M. R.: Isolation and characterization of griffithsin, a novel HIV-inactivating protein from the red alga Griffithsia sp. J. Biol. Chem. 280: 9345-9353, 2005. PubMed Neighbors, J. D.; Beutler, J. A. and Wiemer, D. F.: Synthesis of Nonracemic 3-Deoxyschweinfurthin B. J. Org. Chem. 70: 925-931, 2005. PubMed Nellis, D. F.; Giardina, S. L.; Janini, G. M.; Shenoy, S. R.; Marks, J. D.; Tsai, R.; Drummond, D. C.; Hong, K.; Park, J. W.; Ouellette, T. F.; Perkins, S. C. and Kirpotin, D. B.: Preclinical manufacture of anti HER2 liposome-inserting, scFv-PEG-Lipid conjugate. 2. Conjugate micelle identity, purity, stability and potency analysis. Biotechnol. Prog. 21: 221-232. 2005. PubMed Oku, N.; Krishnamoorthy, R.; Benson, A. G.; Ferguson, R. L.; Lipton, M. A.; Phillips, L. R.; Gustafson, K. R.; and McMahon, J. B. Complete sterochemistry of Neamphamide A and absolute configuration of the ²-Methoxytyrosine residue in Papuamide B. J. Org. Chem. 70: 6842-6847, 2005. PubMed Witvrouw, M.; Fikkert, V.; Hantson, A.; Pannecouque, C.; O'Keefe, B. R.; McMahon, J.; Stamatatos, L.; De Clercq, E. and Bolmstedt, A. Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A. J. Virol. 79(12): 7777-7784, 2005. PubMed Adams, E.W.; Ratner, D.M.; Bokesch, H.R.; McMahon, J.B.; O'Keefe, B.R. and Seeberger, P.H.: Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology: Glycan-dependent gp 120/protein interactions. Chemistry & Biology. 11(6): 875-881, 2004. PubMed Barry, D. G.; Daly, N. L.; Bokesch, H. R.; Gustafson, K. R.; Craik, D. J.: Solution structure of the cyclotide palicourein: Implications for the development of a pharmaceutical framework. Structure 12: 85-94, 2004. PubMed Bokesch, H. R.; Charan, R. D.; Meragelman, K. M.; Gardella, R. S.; Beutler, J. A.; O'Keefe, B. R.; McKee, T. C. and McMahon, J. B.: Isolation and characterization of anti-HIV peptides from Dorstenia contrajerva and Treculia obovoidea. FEBS Lett. 567: 287-290, 2004. Abstract PubMed Bringans, S. D.; O'Keefe, B. R.; Bray, M.; Whitehouse, C. A. and Boyd, M. R.: Development of a fluorescent microplate assay for determining cyanovirin-N levels in plasma. Anal. Bioanal. Chem. 380: 269-274, 2004. PubMed Chan, K. C.; Budihas, S. R.; LeGrice, S. F. J.; Parniak, M. A.; Crouch, R. J.; Gaidamakov, S. A.; Isaaq, H. J.; Wamiru, A.; McMahon, J. B. and Beutler, J. A.: A capillary electrophoretic assay for ribonuclease H activity. Anal. Biochem. 331: 296-302, 2004. PubMed Charan, R. D.; McKee, T. C.; Boyd, M. R.: Cytotoxic alkaloids from the marine sponge Thorectandra sp., Nat. Prod. Res. 18: 225-229, 2004. Abstract PubMed Daily, N. L.; Gustafson, K. R. and Craik, D. J.: The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1. FEBS Lett. 574: 69-72, 2004. PubMed Gustafson, K. R.; McKee, T. C.; Bokesch, H. R.: Anti-HIV cyclotides. Curr. Prot. Pept. Sci. 5: 331-340, 2004. PubMed Han, Z.; Simpson, J. T.; Fivash, M. J.; Fisher, R.; Mori, T.: Identification and characterization of peptides that bind to cyanovirin-N, a potent human immunodeficiency virus-inactivating protein. Peptides 25: 551-561, 2004. PubMed Hess, S.; Gustafson, K. R.; Milanowski, D. J.; Alvira, E.; Lipton, M. A. and Pannell, L. K.: Chirality determination of unusual amino acids using precolumn derivatization and liquid chromatography electrospray ionization mass spectrometry. J Chromatogr. A. 1035: 211-219, 2004. PubMed Lopanik, N.; Gustafson, K. R. and Lindquist, N.: Structure of bryostatin 20: A symbiont-produced chemical defense for larvae of the host bryozoan, Bugula neritina. J. Nat. Prod. 67: 1412-1414, 2004. PubMed Mayer, A. M. and Gustafson, K. R.: Marine pharmacology in 2001-2: antitumor and cytotoxic compounds. Eur. J Cancer. 40: 2676-2704, 2004. PubMed Meragelman, K. M.; McKee, T. C. and McMahon, J. B.: Monanchorin, a bicyclic alkaloid from the sponge Monanchora ungiculata. J. Nat. Prod. 67: 1165-1167, 2004. Abstract PubMed Milanowski, D. J.; Rashid, M. A.; Gustafson, K. R.; O'Keefe, B. R.; Nawrocki, J. P.; Pannell, L. K. and Boyd, M. R. Cyclonellin, a new cyclic octapeptide from the marine sponge Axinella carteri. J. Nat. Prod. 67: 441-444, 2004. Abstract PubMed Milanowski, D. J.; Gustafson, K. R.; Kelley, J. A.; McMahon, J. B.: Caulibugulones A-F, novel cytotoxic isoquinoline quinones and iminoquinolines from the marine bryozoan Caulibugula intermis. J.Nat.Prod. 67: 70-73, 2004. Abstract PubMed Milanowski, D. J.; Gustafson, K. R.; Rashid, M. A.; Pannell, L. K.; McMahon, J. B.; Boyd, M. R.: Gymnangiamide, a novel cytotoxic pentapeptide from the marine hydroid Gymnangium regae. J. Org. Chem. 69: 3036-3042, 2004. Abstract PubMed Mori, T.: Cancer-specific ligands identified from screening of peptide-display libraries. Current Pharmaceutical Design 10: 2335-2343, 2004. PubMed Oku, N.; Gustafson, K. R.; Cartner, L. K.; Wilson, J. A.; Shigematsu, N.; Hess, S.; Pannell, L. K.; Boyd, M. R. and McMahon, J. B.: Neamphamide A, a new HIV-inhibitory depsipeptide from the Papua New Guinea marine sponge Neamphius huxleyi. J. Nat. Prod. 67: 1407-1411, 2004. Abstract PubMed Pai, H. V.; Kommaddi, R. P.; Chinta, S. J.; Mori, T.; Boyd, M. R.; Ravindranath, V.: A frame shift mutation and alternate splicing in human brain generates a functional form of the pseudogene, cytochrome P4502D7 that demethylates codeine to morphine. J. Biol. Chem. 279: 27383-27289, 2004. PubMed Ratner, D. M.; Adams, E. W.; Su, J.; O'Keefe, B. R.; Mrksich, M.; Seeberger, P. H.: Probing protein - carbohydrate interactions with microarrays of synthetic oligosaccharides. ChemBioChem. 5: 379-383, 2004. PubMed Tsai, C. C.; Emau,P.; Jiang, Y. H.; Agy, M. B.; Shattock, R. J.; Schmidt, A.; Morton, W. R.; Gustafson, K. R.; Boyd, M. R.: Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models. AIDS Res.Hum.Retroviruses. 20: 11-18, 2004. Abstract PubMed Adams, E. W.; Ueberfeld, J.; Ratner, D. M.; O'Keefe, B. R.; Walt, D. R.; Seeberger, P. H. Encoded fiber-optic microsphere arrays for probing protein-carbohydrate interactions. Angew.Chem.Int.Ed Engl. 42: 5317-5320, 2003. PubMed Barrientos, L.G.; O'Keefe, B.R.; Bray, M.; Sanchez, A.; Gronenborn, A.M.; Boyd, M.R.: Cyanovirin-N binds to the viral surface glycoprotein GP1,2 and inhibits infectivity of Ebola virus. Antiviral Res. 1767: 1-10, 2003. PubMed Beutler, J.A.; McKee, T.C.: Novel marine and microbial natural product inhibitors of vacuolar ATPase. Curr. Med. Chem. 10: 787-796, 2003. PubMed Bowman, E. J.; Gustafson, K. R.; Bowman, B. J.; Boyd, M. R.: Identification of a new chondropsin class of antitumor compound that selectively inhibits V-ATPases. J.Biol.Chem. 278: 44147-44152, 2003. PubMed Bokesch, H.R.; O'Keefe, B.R.; Pannell, L.K.; Patterson, G.M.L.; McKee, T.C.; Gardella, R.S.; Sowder, R.C. II; Burrier, J.; Watson, K.; Buckheitt, R.W. Jr.; Boyd, M.R.: A novel anti-HIV protein from Scytonema varium. Biochemistry 42: 2578-2584, 2003. PubMed Chen, X.; Beutler, J. A.; Loehfelm, A.; Yang,L.; Dong, H-F.; Chertov, O.; Oppenheim, J. J.; Howard, O.M.Z.: Tannic acid is a novel CXCL12 (SDF1)/CXCR4 inhibitor with potential anti-angiogenic activity. Clin.Cancer Res. 9: 3115-3123, 2003. PubMed Erickson, K. L.; Gustafson, K. R.; Milanowski, D. J.; Pannell, L. K.; Klose, J. R.; Boyd, M. R.: Myriastramides A-C, new modified cyclic peptides from the Phillipines marine sponge Myriastra clavosa. Tetrahedron 59: 10231-10238, 2003. Abstract Mayer, A. M. S.; Gustafson, K. R.: Marine Pharmacology in 2000: Antitumor and Cytotoxic Compounds. Int. J. Cancer 105: 291-299, 2003. PubMed O'Keefe, B.R.; Smee, D.; Turpin, J.; Saucedo, C.; Gustafson, K.R.; Mori, T.; Blakeslee, D.; Buckheit, R.W.; Boyd, M.R.: Potent anti-influenza activity and viral hemagglutinin interaction of cyanovirin-N. Antimicrob. Agents Chemother.47: 2518-2525, 2003. PubMed Parniak, M. A.; Min, K. L.; Budihas, S. R.; Le Grice, S. F. J.; Beutler, J. A.: A fluorescence-based high-throughput screening assay for inhibitors of HIV-1 reverse transcriptase associated ribonuclease H activity. Anal.Biochem. 322: 33-39, 2003. PubMed Tsai, C.; Emau, P.; Jiang, Y.; Tian, B.; Morton, W. R.; Gustafson, K. R.; Boyd, M. R.: Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV 89.6 in macaques. AIDS Res. Human Retrovir. 19: 535-541, 2003. PubMed Barrientos, L.G., Louis, J.M., Hung, J., Smith, T.H., O'Keefe, B.R., Gardella, R.S., Mori, T., Boyd, M.R., Gronenborn, A.M. Design and initial characterization of a circular permuted variant of the potent HIV-inactivating protein cyanovirin-N. Proteins 46: 153-160, 2002. Abstract PubMed Barrientos, L.G., Louis, J.M., Botos, I., Mori, T., Han, Z.Z., O'Keefe, B.R., Boyd, M.R., Wlodawer, A., Gronenborn, A.M. The domain-swapped dimer of cyanovirin-N is in a metastable folding intermediate. Reconciliation of X-ray and NMR structures. Structure 10: 673-686, 2002. Abstract PubMed Beutler, J.A., McMahon, J.B., Johnson, T.R., O'Keefe, B.R., Buzzell, R.A., Robbins, D., Gardella, R., Wilson, J., Boyd, M.R. High throughput screening for cyanovirin-N mimetics binding to HIV-1 gp41. J.Biomolecular Screening 7: 105-110, 2002. Abstract PubMed Bokesch, H.R., Stull, A.C., Pannell, L.K., McKee, T.C., Boyd, M.R.: A new pentacyclic sulfated hydroquinone from the marine sponge Haliclona sp.Tet.Lett. 43: 3079-3081, 2002. Abstract Botos, I., Mori, T., Cartner, L.K., Boyd, M.R., and Wlodawer, A.: Domain-swapped structure of a mutant of cyanovirin-N. Biochem. Biophys. Res. Commun. 294: 184-190, 2002. Abstract PubMed Botos, I., O'Keefe, B.R., Shenoy, S.R., Cartner, L.K., Ratner, D.M., Seeberger, P.H., Boyd, M.R., Wlodawer, A.: Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high-mannose oligosaccharides. J. Biol. Chem. 277: 34336-34342, 2002. Abstract PubMed Charan, R.D., McKee, T.C., Boyd, M.R.: Thorectandrols C, D and E, new sesterterpenes from the marine sponge Thorectandra sp. J.Nat.Prod. 65: 492-495, 2002. Abstract PubMed Charan, R. D.; McKee, T. C.; Gustafson, K. R.; Pannell, L. K.; Boyd, M. R., Theorectandramine, a Novel ²-carboline alkaloid from the marine sponge Thorectandra sp., Tetrahedron Lett. 43: 5201-5204, 2002. Erickson,K.L.; Gustafson,K.R.; Pannell,L.K.; Beutler,J.A.; Boyd,M.R.: New dimeric macrolide glycosides from the marine sponge Myriastra clavosa. J. Nat. Prod. 65: 1303-1306, 2002. Abstract PubMed Giomarelli, B., Mori, T., Provvedi, R., Meacci, F., Maggi, T., McMahon, J.B., Gardella, R., Medaglini, D., Boyd, M.R., Pozzi, G.: The microbicide cyanovirin-N expressed on the surface of commensal bacterium Streptococcus gordonii captures HIV-1. AIDS 16: 1351-1356, 2002. Abstract PubMed Han, Z.Z.; Xiong, C.Y.; Mori, T.; Boyd, M.R.: Discovery of a stable dimeric mutant of cyanovirin-N (CV-N) from a T7 phage-displayed CV-N mutant library. Biochem.Biophys.Res.Comm. 292: 1036-1043, 2002. Abstract PubMed Meragelman, K.M.; West, L.M.; Northcote, P.T.; Pannell, L.K.; McKee, T.C. and Boyd, M.R.: Unusual sulfamate indoles and a novel indolo[3,2-a]carbazole from Ancorina sp. J.Org.Chem. 67: 6671-6677, 2002. Abstract Mori,T.; Barrientos,L.G.; Han,Z.Z.; Gronenborn,A.M.; Turpin,J.A.; Boyd,M.R.: Functional homologs of cyanovirin-N amenable to mass production in prokaryotic and eukaryotic hosts. Protein Expr. Purif. 26: 42-49, 2002. Abstract PubMed Pettit,G.R.; Ducki,S.; Tan,R.; Gardella,R.S.; McMahon,J.B.; Boyd,M.R.; Pettit,G.R.III; Blumberg,P.M.; Lewin,N.E.; Doubek,D.L.; Tackett,L.P.; Williams,M.D.: Isolation and structure of pedilstatin from a Republic of Maldives Pedilanthus sp. J. Nat. Prod. 65: 1262-1265, 2002. Abstract PubMed Rashid, M.A., Gustafson, K.R., Crouch, R.N., Groweiss, A., Pannell, L.K., Van, Q.N. and Boyd, M.R.: Application of high-field NMR and cryogenic probe technologies in the structural elucidation of poecillastrin A, a new antitumor macrolide lactam from the sponge Poecillastra species. Org. Lett. 4: 3293-3296, 2002. Abstract Shenoy,S.R.; Barrientos,L.G.; Ratner,D.M.; O'Keefe,B.R.; Seeberger,P.H.; Gronenborn,A.M.; Boyd,M.R.: Multisite and multivalent binding between cyanovirin-N and branched oligomannosides: Calorimetric and NMR characterization . Chem.Biol. 9: 1109-1118, 2002. Abstract PubMed Bokesch, H.R., Pannell, L.K., Cochran, P.K., Sowder, R.C.II, McKee, T.C., Boyd, M.R.: A novel anti-HIV macrocyclic peptide from Palicourea condensata. J.Nat.Prod. 64: 249-250, 2001. Abstract PubMed Bolmstedt, A., O'Keefe, B. R., Shenoy, S. R., McMahon, J. B., Boyd, M. R.: Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-dependent manner. Mol.Pharmacol. 59: 949-954, 2001. Abstract PubMed Boyd, M.R., Farina, C., Belfiore, P., Gagliardi, S., Kim, J.W., Hayakawa, Y., Beutler, J.A., McKee, T.C., Bowman, B.J., Bowman, E.J.: Novel antitumor benzolactone enamide class selectively inhibits mammalian vacuolar-type (H+)-ATPases. J.Pharmacol.Exp.Ther. 297: 114-120, 2000. Abstract PubMed Full Text Charan, R.D., McKee, T.C., Boyd, M.R.: Thorectandrols A and B, new cytotoxic sesterterpenes from the marine sponge Thorectandra species. J.Nat.Prod. 64: 661-663, 2001. Abstract PubMed Kulkowsky, J., Roman, J., Schnell, M., Pomerantz, R.J., Culnan, D.M., Dornadula, G., Boyd, M.R.: Prostratin: activation of latent HIIV-1 expression suggests a potential inductive adjuvant therapy for HAART. Blood, 98: 3006-3015, 2001. Abstract PubMed Kuroda, M., Mimaki, Y., Yokosuka, A., Sashida, Y., Beutler, J.A.: Cytotoxic cholestane glycosides from the bulbs of Ornithogalum saundersiae. J.Nat.Prod. 64: 88-91, 2001. PubMed Meragelman, K.R., McKee, T.C., Boyd, M.R.: 10-Demethoxystegane, a new lignan from Steganotaenia araliacea. J.Nat.Prod. 64: 1480-1482, 2001. Abstract PubMed Meragelman, K.M., McKee, T.C., Boyd, M.R.: Anti-HIV prenylated flavonoids from Monotes africanus. J.Nat.Prod., 64: 546-548, 2001. Abstract PubMed Meragelman, K.M., McKee, T.C., Boyd, M.R.: New cytotoxic isomalabaricane triterpenes from the sponge Jaspis species. J.Nat.Prod. 64: 389-392, 2001. Abstract PubMed Mori, T., Boyd, M.R.: Cyanovirin-N, a potent human immunodeficiency virus-inactivating protein, blocks both CD4-dependent and CD4-independent binding of gp120 to target cells, inhibits sCD4-induced binding of gp120 to cell-associated coreceptor, and dissociates bound gp120 from target cells. Antimicrob.Agents Chemother. 45: 664-672, 2001. Abstract PubMed O'Keefe, B. R.: Biologically active proteins from natural product extracts. J.Nat.Prod. 64: 1373-1381, 2001. Abstract PubMed Rashid, M.A., Gustafson, K.R., Boyd, M.R.:New cytotoxic N-methylated ß-carboline alkaloids from the marine ascidian Eudistoma gilboverde. J.Nat.Prod. 64: 1454-1456, 2001. Abstract PubMed Rashid, M.A., Cantrell, C.L., Gustafson, K.R., Boyd, M.R.: Chondropsin D, a new 37-membered-ring macrolide lactam from the marine sponge Chondropsis sp. J.Nat.Prod. 64: 1341-1344, 2001. Abstract PubMed Rashid, M.A., Gustafson, K.R., Cardellina, J.H.II, Boyd, M.R. Absolute stereochemistry and anti-HIV activity of miquartynoic acid, a polyacetylene from Ochanostachys amentacea. Nat.Prod.Lett. 15: 21-26, 2001. Abstract PubMed Rashid, M.A., Gustafson, K.R., Boyd, M.R.: New chondropsin macrolide lactams from marine sponges in the genus Ircinia. Tet. Lett. 42: 1623-1626, 2001. Abstract Rashid, M.A., Gustafson, K.R., Cartner, L.K., Shigematsu, N., Pannell, L.K., Boyd, M.R.: Microspinosamide, a new HIV-inhibitory cyclic depsipeptide from the marine sponge Sidonops microspinosa. J.Nat.Prod. 64: 117-121, 2001. Abstract PubMed Rashid,M.A.; Gustafson,K.R.; Cartner,L.K.; Pannell,L.K.; Boyd,M.R.: New nitrogenous constituents from the South African marine ascidian Pseudodistoma sp. Tetrahedron 57: 5751-5755, 2001. Abstract Rashid, M.A., Gustafson, K.R., Boyd, M.R.: A new isoquinoline alkaloid from the marine sponge Haliclona species. J.Nat.Prod. 64: 1249-1250, 2001. Abstract PubMed Shenoy, S.R., O'Keefe, B. R., Bolmstedt, A. J., Cartner, L. K., Boyd, M. R.: Selective interactions of the HIV-inactivating protein, cyanovirin-N, with high-mannose oligosaccharides on gp120 and other glycoproteins. J.Pharmacol.Exp.Ther. 297: 704-710, 2001. Abstract PubMed 2000Beutler, J.A., McCall, K.L., Herbert, K., Johnson, T., Shoemaker, R.H., Boyd, M.R.: Cytotoxic clerodane diterpene esters from Laetia corymbulosa. Phytochemistry 55: 233-236, 2000. Abstract PubMed Beutler, J.A., Jato, J., Cragg, G.M., Boyd, M.R.: Schweinfurthin D, a cytotoxic stilbene from Macaranga schweinfurthii. Nat.Prod.Lett. 14: 399-404, 2000. Abstract Beutler, J.A., McCall, K.L., Herbert, K., Herald, D.L., Pettit, G.R., Johnson, T., Shoemaker, R.H., Boyd, M.R.: Novel cytotoxic diterpenes from Casearia arborea (Flacourtiaceae). J.Nat.Prod. 63: 657-661, 2000. Abstract PubMed Bokesch, H.R., Pannell, L.K., McKee, T.C., Boyd, M.R.: Coscinamides A, B, and C, three new bis indole alkaloids from the marine sponge Coscinoderma sp. Tet.Lett., 41: 6305-6308 (2000). Abstract Cantrell, C.L., Gustafson,, K.R., Cecere, M.R., Pannell, L.K., Boyd, M.R.: Chondropsins A and B: Novel tumor cell growth-inhibitory macrolide lactams from the marine sponge Chondropsis sp. J.Am.Chem.Soc. 122: 8825-8829, 2000. Abstract Full Text Charan, R.D., Munro, M.H.G., O'Keefe, B.R., Sowder, R.C. II, McKee, T.C., Currens, M.J., Pannell, L.K., Boyd, M.R.: Isolation and characterization of Myrianthus holstii lectin, a potent HIV-1 inhibitory protein from the plant Myrianthus holstii. J.Nat.Prod. 63:1170-1174, 2000. Abstract PubMed Cragg, G.M., Boyd, M.R., Hallock, Y.F., Newman, D.J., Sausville, E.A., Wolpert, M.K. Natural products drug discovery at the National Cancer Institute. Past achievements and new directions for the new millenium. In: Biodiversity: A source of new leads for the pharmaceutical and agrochemical industries. Royal Society of Chemistry, London, 2000, pp. 22-44. Davies-Coleman, M.T., Cantrell, C.L., Gustafson, K.R., Beutler, J.A., Pannell, L.K., Boyd, M.R.: Stolonic acids A and B, new cytotoxic cyclic peroxides from an Indian Ocean ascidian Stolonica sp. J.Nat.Prod. 63: 1411-1413, 2000. Abstract PubMed Dey, B., Lerner, D.L., Lusso, P., Boyd, M.R., Elder, J.H., Berger, E.A.: Multiple antiviral activities of cyanovirin-N: Blocking of gp120 interaction with CD4 and coreceptor, and inhibition of diverse enveloped viruses. J.Virol. 74: 4562-4569, 2000. Abstract PubMed Gandhi, M.J., Boyd, M.R., Yang, G.G., Vyas, G.N.: Properties of cyanovirin-N (CV-N): Inactivation of HIV-1 by sessile cyanovirin-N (sCV-N). In: Brown, F., Vyas, G. (eds.): Advances in Transfusion Safety: Development of Biologics vol.102. Basel, S.Karger, 2000, pp.141-148. Abstract Groweiss, A., Cardellina, J.H. II, Boyd, M.R.: HIV-inhibitory xanthones and flavones from Maclura tinctoria. J.Nat.Prod. 63: 1537-1539, 2000. Abstract PubMed Gustafson, K.R., Walton, L.K., Sowder, R.C.II, Johnson, D.G., Pannell, L.K., Cardellina, J.H.II, Boyd, M.R. New circulin macrocyclic peptides from Chassalia parvifolia. J.Nat.Prod. 62: 176-178, 2000. Abstract PubMed Hallock, Y.F., Sowder, R.C. II, Pannell, L.K., Hughes, C.B., Johnson, D.G., Gulakowski, R.G., Cardellina, J.H.II, Boyd, M.R.: Cycloviolins A-D, new anti-HIV macrocyclic peptides from Leonia cymosa. J.Org.Chem. 65: 124-128, 2000. Abstract Keskin, O., Bahar, I., Jernigan, R.L., Myers, T.G., Beutler, J.A., Shoemaker, R.H., Sausville, E.A., Covell, D.G. Characterization of anticancer agents by their growth-inhibitory activity and relationships to mechanism of action and structure. Anti-Cancer Drug Design 15: 79-98, 2000. PubMed McMahon, J.B., Beutler, J.A., O'Keefe, B.R., Goodrum, C.B.B., Myers, M.A., Boyd, M.R.: Development of a cyanovirin-N/HIV-1 gp120 binding assay for high throughput screening of natural products by time-resolved fluorescence. J. Biomolecular Screening 5: 169-176, 2000. Abstract PubMed Meragelman, K.M., McKee, T.C., Boyd, M.R.: Siamenol, a new carbazole alkaloid from Murraya siamensis. J.Nat.Prod. 63: 427-428, 2000. Abstract PubMed O'Keefe, B.R., Shenoy, S.R., Xie, D., Zhang, W., Muschik, J.M., Currens, M.J., Chaiken, I., Boyd, M.R.: Analysis of the interaction between the HIV-inactivating protein cyanovirin-N and soluble forms of the envelope glycoproteins gp120 and gp41. Mol.Pharmacol. 58: 982-992, 2000. Abstract PubMed Rashid, M.A., Gustafson, K. R., Boyd, M. R.: Pellynol I, a new cytotoxic polyacetylene from the sponge Pellina sp. Nat.Prod.Lett. 15: 387-392, 2000. Abstract Rashid, M.A., Gustafson, K.R., Boyd, M.R.: HIV-inhibitory cembrane derivatives from a Phillipines collection of the soft coral Lobophytum sp. J.Nat.Prod. 63: 531-533, 2000. Abstract PubMed Rashid, M.A., Gustafson, K.R., Boswell, J.L., Boyd, M.R.: Haligramides A and B, two new cytotoxic hexapeptides from the marine sponge Haliclona nigra. J.Nat.Prod. 63: 956-959, 2000. Abstract PubMed Rashid, M.A., Gustafson, K.R., Cardellina, J.H.II, Boyd, M.R.: A new podophyllotoxin derivative from Bridelia ferruginea. Nat.Prod.Lett. 14: 285-292, 2000. Abstract Uddin Biswas, M.H., Ruhul Amin, A.R.M., Islam, M.A., Hasan, C.M., Gustafson, K.R., Boyd, M.R., Pannell, L.K., Rashid, M.A.: Monocillinols A and B, novel fungal metabolites from a Monocillium sp. Tet.Lett. 41: 7177-7180 (2000). Abstract
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