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Dicentric Chromosomes
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Conventional Lymphocyte Metaphase-Dicentric Assay
- Left panel: A schematic illustrating radiation-induced DNA damage (see left side of image) in an interphase cell and the resulting formation of radiation-induced dicentric (DIC) and accompanying acentric fragment (Ac) chromosome aberration in lymphocytes arrested in metaphase mitosis.
- Right panel: Dose response relationship for dicentrics in human lymphocytes exposed to incremental radiation doses from three radiation qualities.
Figure from Blakely WF, Salter CA, Prasanna PG. Early-response biological dosimetry--recommended countermeasure enhancements for mass-casualty radiological incidents and terrorism. Health Phys. 2005 Nov;89(5):494-504. [PubMed Citation]
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