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| On the Cover | Although substantial improvements in health, particularly in children’s health, have come about as a result of the banning of leaded gasoline, lead remains a health hazard for subpopulations of both children and adults. In the United States, new research is looking at effects of lead at low doses in adults. This month’s Focus (p. A30) examines these findings and presents the debate over how far remediation should go to protect people against potential effects of this weighty metal.
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Perspectives
Editorial
p. A 12
Director's Perspective
p. A 13
Correspondence
p. A 14
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Environews
Forum
p. A 20
NIEHS News
p. A 24
Focus
p. A 30
Innovations
p. A 38
Science Selections
p. A 42
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Commentaries & Reviews
Reviews
ETHICS | Source of Funding and Results of Studies of Health Effects of Mobile Phone Use: Systematic Review of Experimental Studies
Anke Huss, Matthias Egger, Kerstin Hug, Karin Huwiler-Müntener, and Martin Röösli
p. 1 [ Abstract ] [ Full ] [ PDF ]
NANOTECHNOLOGY | Ethical and Scientific Issues of Nanotechnology in the Workplace
Paul A. Schulte, Fabio Salamanca-Buentello
p. 5 [ Abstract ] [ Full ] [ PDF ]
Research
CARDIOVASCULAR DISEASE | The Effects of Components of Fine Particulate Air Pollution on Mortality in California: Results from CALFINE
Bart Ostro, Wen-Ying Feng, Rachel Broadwin, Shelley Green, and Michael Lipsett
p. 13 [ Abstract ] [ Full ] [ PDF ]
HUMAN TOXICOLOGY | Polychlorinated Biphenyls and Their Hydroxylated Metabolites (OH-PCBs) in Pregnant Women from Eastern Slovakia
June-Soo Park, Linda Linderholm, M. Judith Charles, Maria Athanasiadou, Jan Petrik, Anton Kocan, Beata Drobna, Tomas Trnovec, Åke Bergman, and Irva Hertz-Picciotto
p. 20 [ Abstract ] [ Full ] [ PDF ]
BIOMARKERS | Albumin Adducts of Electrophilic Benzene Metabolites in Benzene-Exposed and Control Workers
Yu-Sheng Lin, Roel Vermeulen, Chin H. Tsai, Suramya Waidyanatha, Qing Lan, Nathaniel Rothman, Martyn T. Smith, Luoping Zhang, Min Shen, Guilan Li, Songnian Yin, Sungkyoon Kim, and Stephen M. Rappaport
p. 28 [ Abstract ] [ Full ] [ PDF ]
POLYMORPHISM | Lead and δ-Aminolevulinic Acid Dehydratase Polymorphism: Where Does It Lead? A Meta-Analysis
Franco Scinicariello, H. Edward Murray, Daphne B. Moffett, Henry G. Abadin, Mary J. Sexton, and Bruce A. Fowler
p. 35 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Maternal Fish Consumption, Mercury Levels, and Risk of Preterm Delivery
Fei Xue, Claudia Holzman, Mohammad Hossein Rahbar, Kay Trosko, and Lawrence Fischer
 Also see Science Selections, p. A43
p. 42 [ Abstract ] [ Full ] [ PDF ]
IMMUNOLOGY | Environmental Estrogens Induce Mast Cell Degranulation and Enhance IgE-Mediated Release of Allergic Mediators
Shin-ichiro Narita, Randall M. Goldblum, Cheryl S. Watson, Edward G. Brooks, D. Mark Estes, Edward M. Curran, and Terumi Midoro-Horiuti
p. 48 [ Abstract ] [ Full ] [ PDF ]
CARDIOVASCULAR DISEASE | A Case–Control Analysis of Exposure to Traffic and Acute Myocardial Infarction
Cathryn Tonne, Steve Melly, Murray Mittleman, Brent Coull, Robert Goldberg, and Joel Schwartz
Also see Science Selections, p. A42
p. 53 [ Abstract ] [ Full ] [ PDF ]
INFECTIOUS DISEASE | Tracking Patterns of Enteric Illnesses in Populations and Communities
Terry Peace and Asit Mazumder
p. 58 [ Abstract ] [ Full ] [ PDF ]
NEURODEVELOPMENT | Nonenzymatic Functions of Acetylcholinesterase Splice Variants in the Developmental Neurotoxicity of Organophosphates: Chlorpyrifos, Chlorpyrifos Oxon, and Diazinon
Ruth R. Jameson, Frederic J. Seidler, and Theodore A. Slotkin
p. 65 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | Polybrominated Diphenyl Ether Levels in the Blood of Pregnant Women Living in an Agricultural Community in California
Asa Bradman, Laura Fenster, Andreas Sjödin, Richard S. Jones, Donald G. Patterson Jr., and Brenda Eskenazi
p. 71 [ Abstract ] [ Full ] [ PDF ]
EPIDEMIOLOGY | Increased Rate of Hospitalization for Diabetes and Residential Proximity of Hazardous Waste Sites
Maria Kouznetsova, Xiaoyu Huang, Jing Ma, Lawrence Lessner, and David O. Carpenter
p. 75 [ Abstract ] [ Full ] [ PDF ]
CARCINOGENESIS | Prenatal Bisphenol A Exposure Induces Preneoplastic Lesions in the Mammary Gland in Wistar Rats
Milena Durando, Laura Kass, Julio Piva, Carlos Sonnenschein, Ana M. Soto, Enrique H. Luque, and Mónica Muñoz-de-Toro
p. 80 [ Abstract ] [ Full ] [ PDF ]
MUTAGENESIS | New Insight into Intrachromosomal Deletions Induced by Chrysotile in the gpt delta Transgenic Mutation Assay
An Xu, Lubomir B. Smilenov, Peng He, Ken-ichi Masumura, Takehiko Nohmi, Zengliang Yu, and Tom K. Hei
p. 87 [ Abstract ] [ Full ] [ PDF ]
BIOSENSORS | Screening for Developmental Neurotoxicity Using PC12 Cells: Comparisons of Organophosphates with a Carbamate, an Organochlorine, and Divalent Nickel
Theodore A. Slotkin, Emiko A. MacKillop, Ian T. Ryde, Charlotte A. Tate, and Frederic J. Seidler
p. 93 [ Abstract ] [ Full ] [ PDF ]
INFECTIOUS DISEASE | Potential Risks Associated with the Proposed Widespread Use of Tamiflu
Andrew C. Singer, Miles A. Nunn, Ernest A. Gould, and Andrew C. Johnson
Also see Science Selections, p. A42
p. 102 [ Abstract ] [ Full ] [ PDF ]
Environmental Medicine
RISK CHARACTERIZATION | Grand Rounds: An Outbreak of Toxic Hepatitis among Industrial Waste Disposal Workers
Hae-Kwan Cheong, Eun A Kim, Jung-Keun Choi, Sung-Bong Choi, Jeong-Ill Suh, Dae Seob Choi and Jung Ran Kim
p. 107 [ Abstract ] [ Full ] [ PDF ]
NEURODEGENERATIVE DISEASE | Grand Rounds: Could Occupational Exposure to n-Hexane and Other Solvents Precipitate Visual Failure in Leber Hereditary Optic Neuropathy?
Valerio Carelli, Flavia Franceschini, Silvia Venturi, Piero Barboni, Giacomo Savini, Giuseppe Barbieri, Ettore Pirro, Chiara La Morgia, Maria L. Valentino, Francesca Zanardi, Francesco S. Violante, and Stefano Mattioli
p. 113 [ Abstract ] [ Full ] [ PDF ]
Children's Health
BIOMARKERS | Pilot Study of Urinary Biomarkers of Phytoestrogens, Phthalates, and Phenols in Girls
Mary S. Wolff, Susan L. Teitelbaum, Gayle Windham, Susan M. Pinney, Julie A. Britton, Carol Chelimo, James Godbold, Frank Biro, Lawrence H. Kushi, Christine M. Pfeiffer, 6 and Antonia M. Calafat
Also see Science Selections, p. A43
p. 116 [ Abstract ] [ Full ] [ PDF ]
NEUROBEHAVIORAL DISEASE | Hair Manganese and Hyperactive Behaviors: Pilot Study of School-Age Children Exposed through Tap Water
Maryse Bouchard, François Laforest, Louise Vandelac, David Bellinger, and Donna Mergler
p. 122 [ Abstract ] [ Full ] [ PDF ]
NEUROBEHAVIORAL DISEASE | Effect of Community of Residence on Neurobehavioral Development in Infants and Young Children in a Flower-Growing Region of Ecuador
Alexis J. Handal, Betsy Lozoff, Jaime Breilh, and Siobán D. Harlow
p. 128 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Household Pesticides and the Risk of Wilms Tumor
Maureen A. Cooney, Julie L. Daniels, Julie A. Ross, Norman E. Breslow, Brad H. Pollock, and Andrew F. Olshan
p. 134 [ Abstract ] [ Full ] [ PDF ]
Mini-monograph
CANCER | Risk Factors for Acute Leukemia in Children: A Review
Martin Belson, Beverely Kingsley, and Adrianne Holmes
p. 138 [ Abstract ] [ Full ] [ PDF ]
CANCER | Infectious Etiologies of Childhood Leukemia: Plausibility and Challenges to Proof
Siobhán M. O'Connor and Roumiana S. Boneva
p. 146 [ Abstract ] [ Full ] [ PDF ]
CANCER | Investigating Childhood Leukemia in Churchill County, Nevada
Carol S. Rubin, Adrianne K. Holmes, Martin G. Belson, Robert L. Jones, W. Dana Flanders, Stephanie M. Kieszak, John Osterloh, George E. Luber, Benjamin C. Blount, Dana B. Barr, Karen K. Steinberg, Glen A. Satten, Michael A. McGeehin, and Randall L. Todd
p. 151 [ Abstract ] [ Full ] [ PDF ]
CANCER | Genetic Studies of a Cluster of Acute Lymphoblastic Leukemia Cases in Churchill County, Nevada
Karen K. Steinberg, Mary V. Relling, Margaret L. Gallagher, Christopher N. Greene, Carol S. Rubin, Deborah French, Adrianne K. Holmes, William L. Carroll, Deborah A. Koontz, Eric J. Sampson, and Glen A. Satten1
p. 158 [ Abstract ] [ Full ] [ PDF ]
CANCER | An Update on Cancer Cluster Activities at the Centers for Disease Control and Prevention
Beverly S. Kingsley, Karen L. Schmeichel, and Carol H. Rubin
p. 165 [ Abstract ] [ Full ] [ PDF ]
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and Effects of TCE
