Hormone Therapy-Related Mood Symptoms Research Study
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Perimenopause: An observational Study
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This is an observational study for perimenopausal depression in women between the ages of 40 and 60. The purpose of this study is to investigate mood and behavioral changes in the time period surrounding and including menopause. Perimenopausal women with depression symptoms and a control group of healthy perimenopausal volunteers will be compared to one another to identify correlates of the occurrence of depression. Additionally, a group of younger pre-perimenopausal women with normal menstrual cycle functioning will be followed through menopause to observe a possible increase of depressive symptoms around the time of menopause. This is an observational study; volunteers who participate will not receive any new or experimental therapies.
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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Hormone Therapy-Related Mood Symptoms Research Study
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The effects of Acute Withdrawal of Estradiol on Mood Symptoms in Women with Perimenopausal Depression
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If you are a woman between the ages of 45 and 60 and are on estrogen or combination therapy due to perimenopausal mood symptoms, and you now plan to stop your estrogen therapy, we would like you to participate in our study. The purpose of this study is to investigate the effects of estrogen levels on perimenopausal depression. Participants will be randomly assigned to take either estradiol or placebo. Mood-ratings will be used to determine the response to the discontinuation of estradiol.
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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Hormone Therapy-Related Mood Symptoms Research Study
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The treatment of Perimenopausal Depression
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The purpose of this study is to evaluate the effectiveness of two medications in treating perimenopausal-related depression. Selective estrogen receptor modulators (SERMS), such as raloxifene, and phytoestrogens, such as RimostilT, have estrogen-like properties and may be effective treatment. The effect of SERMS and phytoestrogens on mood and cognitive functioning needs to be examined in women with perimenopause-related depression.
Participants in this study will be randomly assigned to receive one of four treatments for 8 weeks. Participants will have clinic visits every 2 weeks, complete self-rating scales, give urine and blood samples and meet with the medical research staff.
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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Perimenopause-Related Mood Disorders Research Study
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Perimenopause: An observational Study
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This is an observational study for perimenopausal depression in women between the ages of 40 and 60. The purpose of this study is to investigate mood and behavioral changes in the time period surrounding and including menopause. Perimenopausal women with depression symptoms and a control group of healthy perimenopausal volunteers will be compared to one another to identify correlates of the occurrence of depression. Additionally, a group of younger pre-perimenopausal women with normal menstrual cycle functioning will be followed through menopause to observe a possible increase of depressive symptoms around the time of menopause. This is an observational study; volunteers who participate will not receive any new or experimental therapies.
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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Perimenopause-Related Mood Disorders Research Study
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The effects of Acute Withdrawal of Estradiol on Mood Symptoms in Women with Perimenopausal Depression
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If you are a woman between the ages of 45 and 60 and are on estrogen or combination therapy due to perimenopausal mood symptoms, and you now plan to stop your estrogen therapy, we would like you to participate in our study. The purpose of this study is to investigate the effects of estrogen levels on perimenopausal depression. Participants will be randomly assigned to take either estradiol or placebo. Mood-ratings will be used to determine the response to the discontinuation of estradiol.
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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Perimenopause-Related Mood Disorders Research Study
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The treatment of Perimenopausal Depression
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The purpose of this study is to evaluate the effectiveness of two medications in treating perimenopausal-related depression. Selective estrogen receptor modulators (SERMS), such as raloxifene, and phytoestrogens, such as RimostilT, have estrogen-like properties and may be effective treatment. The effect of SERMS and phytoestrogens on mood and cognitive functioning needs to be examined in women with perimenopause-related depression.
Participants in this study will be randomly assigned to receive one of four treatments for 8 weeks. Participants will have clinic visits every 2 weeks, complete self-rating scales, give urine and blood samples and meet with the medical research staff.
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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Postpartum Depression Research Study
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Women with a History of Postpartum Depression: The Effects of Hormones in Postpartum Mood Disorders
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If you have ever suffered from postpartum depression (PPD) following childbirth, we would like you to call for information about participation in our study. The study is designed to determine if your PPD was caused by hormonal changes during or after pregnancy. This study will replicate a hormonal state of pregnancy and the 6-week period following delivery. Mood symptoms and hormone levels will be measured throughout the study.
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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Postpartum Depression Research Study
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Women with Postpartum Depression: A Treatment Study
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If you think you may currently have postpartum depression (PPD) following the birth of a child within the past six months, you may want to consider participation in this study. The purpose of this study is to evaluate the effectiveness of estrogen in treating women with postpartum depression (PPD). You will be screened by our medical staff over the phone and in person to determine if you are eligible for the study. If eligible, you will be randomly assigned to wear skin patches containing either estradiol or placebo (a patch with no active ingredient) for 6 weeks. You will complete mood-rating forms, give urine and blood samples and meet with the medical team throughout the study.
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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Postpartum Depression Research Study
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Women with PPD : An observational study
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This is an observational study for postpartum depression (PPD) This study is for three different groups of women: those who recently gave birth and have mild to moderately severe PDD (Group 1), women who recently gave birth and do not have PDD (Group 2), and those who are currently pregnant and experienced an episode of PDD with a previous birth (Group 3). The purpose of this study is to explore the relationship between mood and hormones in women with postpartum depression (PPD). This is an observational study; volunteers who participate will not receive any new or experimental therapies.
If eligible for the study, you will be interviewed about your moods, behaviors, and medical status during and immediately following your last pregnancy. You will complete self-rating scales and some women will be asked to participate in interviews, psychological tests, blood tests and urine samples. You will also participate in genetic studies which examines the role genes have in hormone related mood disorders, including PPD. A genetics test involves completing a questionnaire and providing a simple blood sample. Family members may also participate.
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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Premenstrual Syndrome Research Study
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A PMS Treatment study (Dutasteride)
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Women between the ages of 30 and 45 with regular menstrual cycles may be eligible to participate in this study of premenstrual syndrome (PMS). This study will explore the effects of a medication on mood and the stress throughout the menstrual cycle. If eligible, you will be assigned to receive medication or placebo. Participants will be compensated for their participation.
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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Premenstrual Syndrome Research Study
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PMS evaluation study
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The purpose of this study is to identify and describe the symptoms of premenstrual syndrome (PMS).Women between the ages of 18 and 50 who experience PMS symptoms will be asked to complete clinical interviews, self-rating scales, and evaluations of mood. Your participation in this study will help researchers determine if you are eligible to participate in additional studies exploring the causes of, and treatment for PMS.
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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Premenstrual Syndrome Research Study
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PMS: Researching the possible causes
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If you are a woman between 18 and 45 who experiences premenstrual syndrome (PMS), you may be eligible to help researchers investigate what causes it. This study explores possible causes of PMS by using a medication to stop the menstrual cycle temporarily. After the menstrual cycle is stopped, researchers will add back either estrogen or progesterone. The purpose of this study is to examine the influence of estrogen and progesterone on mood and behavior in women with PMS. Imaging tests will be conducted and the role of serotonin will also be examined.
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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Premenstrual Syndrome Research Study
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PMS: Studying the possible causes
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If you are a woman between 18 and 50 who experiences premenstrual syndrome (PMS), you may be eligible to help researchers investigate what causes it. This study explores possible causes of PMS by using a medication to stop the menstrual cycle temporarily. After the menstrual cycle is stopped, researchers will add back, in sequence, estrogen, and progesterone. The purpose of this study is to examine the influence of estrogen and progesterone on mood and behavior in women with PMS.
To find out if you qualify or for more information, please call (301) 496-9576.
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Disease and Treatment Information |
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Premenstrual Syndrome Research Study
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PMS: Treatment with Combined Hormones
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Women between the ages of 18 and 50 may be eligible to participate in this PMS treatment study. This study will determine if stable hormone levels are effective in preventing mood symptoms in women with PMS. Women will take a medication that will significantly lower their hormone levels of both estrogen and progesterone. Once stable for two months, they will then randomly get hormones or placebo added back. The purpose of this study is to investigate the role of hormones in women with PMS.
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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Premenstrual Syndrome Research Study
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PMS: Treatment with continuous oral contraceptives
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Women between the ages of 18 and 50 who experience premenstrual syndrome may be eligible to participate in this study. The purpose of this study is to determine an effective treatment for PMS. This study examines the effectiveness of using 15 weeks of continuous oral contraceptives to treat premenstrual syndrome (PMS).
To find out if you qualify or for more information, please call (301) 496-9576.
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Protocol Information |
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