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Kenneth D. Paull, Ernest Hamel, Louis Malspeis

Introduction

Methodology

Applications

• Examples of COMPARE used with the Standard Agent Database
• • Antimetabolites
  • • pyrimidine synthesis inhibitors
    • glutamine antagonists
    • ribonucleotide reductase inhibitors
    • anti-folic acid agents
  • Topoisomerase II Agents
  • Antitubulin Agents
  • Alkylating Agents
• Discovery of Novel Compounds with a Particular Mechanism
• • Antitubulin agents
  • Topoisomerase II agents
  • Inosine monophosphate dehydrogenase inhibitors
  • Dihydroorotate dehydrogenase inhibitors
• Use of Molecular Target Measurements as a COMPARE seed
• • Summary of published target work
  • Targets currently under study

Run COMPARE

• Main COMPARE page