Investigators have either shown interest or are in the process of measuring these molecular targets in the NCI screen cell lines. Results will be available as soon as they are published.

• G1, G2 checkpoints
• mismatch repair defects
• bcl-2 family members
• EGR-rec, erbB-2, TGF-alpha
• mdr-2
• thymidylate synthetase
• telomerase, telomer length
• alkylguanine transferase
• PI-3 kinase
• p16
• Rb
• src
• target of Rapamycin
• FGFrec 1, 2, 3, 4
• other tyrosine kinases (95) and phosphorylases (50)
• TGF-beta type II receptor
• DNA methylation and genomic imprinting
• topoisomerase I
• Protein/2-D gel database
• c-myc MAX
• Jun, fos
• NFkB Rel
• Thymidine kinase
• Dihydropyrimidine dehydrogenase
• E2F
• IAP (Inhibitor of apoptotic proteins)
• Histone Isoforms
• cAMP phosphodiesterase
• POH1 Pad-1
• ERCC 1, 2, 3
• hsMad2 (mitotic checkpoint)
• Rho GTPase signaling pathway
• HSP 60, 70, 90
• Apo-1/fas
• IL 2,4,7 receptors
• reduced folate binding protein
• Taxol inducible genes
• PCNA
• Neural Peptide receptors
• MTAP
• comparative genomic hybridazation
• Drug related resistance gene
• AP endonuclease
• Xpa
• poly ADP ribose polymerase
• Cyclins - A, B1, B2, C, D1, D2, D3, E
• CDKs - cdc2, CDK2, CDK4, CDK5, CDK6
• CDCs - cdc7
• CDK Inhibitors - p21, p27, p16, p15, p18, p19
• Suppressors/pocket proteins - pRb, p107, p130
• Modifying enzymes - wee1, myt1, chk1, p78, KIA, EMK, cdc25A, cdc25B, cdc25C
• Effeectors/Substrates - E2F1, E2F2, E2F3, E2F4, E2F5
• Protein Kinases - EGFR, erbB2, erbB3, erbB4, c-src, ERK-1, ERK-2
• Ax1
• BRCA1
• Rak
• Death genes 44a + 1738
• G Proteins (Ras Rap Rac Rho)
• WIF-1
• MECC Kinase
• Caspases 1,2,3,6,7,8,9
• APC gene
• PARP Clevage
• CD YOL + TDAIL miceptors
• ATM
• ATR
• DNA-PK
• mTORIVK
• MAP kinase, ERk, p38, JNK
• Gne Microarray expression profiles
• GFAP
• LDH-A
• Bmi-1
• Programmed Cell Death Gene
• Carbanic Anhydrase CA9 + CA12
• DNA sequence abnormalaties
• Methionine amino peptidase 2
• TIMP (Tissue inhibitors of matrix metallcoproteases)
• Aldoketoreductase