| | This journal provides immediate access to some articles. Editorial From the Academy: Harnessing new science is vital for biodefense and global health Bruce Alberts and Harvey V. Fineberg PMCID: PMC509179 Commentaries Infecting the brain to stop addiction? David Nutt and Anne Lingford-Hughes PMCID: PMC509181 Worm genomes hold the smoking guns of intron gain John M. Logsdon, Jr. PMCID: PMC509182 Perspective From the Academy: Discovery of antivirals against smallpox Stephen C. Harrison, Bruce Alberts, Ellie Ehrenfeld, Lynn Enquist, Harvey Fineberg, Steven L. McKnight, Bernard Moss, Michael O'Donnell, Hidde Ploegh, Sandra L. Schmid, K. Peter Walter, and Julie Theriot PMCID: PMC509180 Physical Sciences Chemistry From the Cover:
Twisting macromolecular chains: Self-assembly of a chiral supermolecule from nonchiral polythiophene polyanions and random-coil synthetic peptides K. Peter R. Nilsson, Johan Rydberg, Lars Baltzer, and Olle Inganäs PMCID: PMC509183 Biological Sciences Applied Biological Sciences Bioreactor-based bone tissue engineering: The influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization Xiaojun Yu, Edward A. Botchwey, Elliot M. Levine, Solomon R. Pollack, and Cato T. Laurencin PMCID: PMC509184 Biochemistry Subfertility and defective folliculogenesis in female mice lacking androgen receptor Yueh-Chiang Hu, Peng-Hui Wang, Shuyuan Yeh, Ruey-Sheng Wang, Chao Xie, Qingquan Xu, Xinchang Zhou, Hsiang-Tai Chao, Meng-Yin Tsai, and Chawnshang Chang PMCID: PMC509185 Neutron crystallographic study on rubredoxin from Pyrococcus furiosus by BIX-3, a single-crystal diffractometer for biomacromolecules Kazuo Kurihara, Ichiro Tanaka, Toshiyuki Chatake, Michael W. W. Adams, Francis E. Jenney, Jr., Natalia Moiseeva, Robert Bau, and Nobuo Niimura PMCID: PMC509186 Discriminatory aptamer reveals serum response element transcription regulated by cytohesin-2 Mirko G. Theis, Alexander Knorre, Bettina Kellersch, Jörg Moelleken, Felix Wieland, Waldemar Kolanus, and Michael Famulok PMCID: PMC509187 Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles Hiroki R. Ueda, Wenbin Chen, Yoichi Minami, Sato Honma, Kenichi Honma, Masamitsu Iino, and Seiichi Hashimoto PMCID: PMC509173 From the Cover:
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase Daria J. Hazuda, Neville J. Anthony, Robert P. Gomez, Samson M. Jolly, John S. Wai, Linghang Zhuang, Thorsten E. Fisher, Mark Embrey, James P. Guare, Jr., Melissa S. Egbertson, Joseph P. Vacca, Joel R. Huff, Peter J. Felock, Marc V. Witmer, Kara A. Stillmock, Robert Danovich, Jay Grobler, Michael D. Miller, Amy S. Espeseth, Lixia Jin, I-Wu Chen, Jiunn H. Lin, Kelem Kassahun, Joan D. Ellis, Bradley K. Wong, Wei Xu, Paul G. Pearson, William A. Schleif, Riccardo Cortese, Emilio Emini, Vincenzo Summa, M. Katharine Holloway, and Steven D. Young PMCID: PMC509174 The ion channel of F-ATP synthase is the target of toxic organotin compounds Christoph von Ballmoos, Josef Brunner, and Peter Dimroth PMCID: PMC509188 Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver Guoxun Chen, Guosheng Liang, Jiafu Ou, Joseph L. Goldstein, and Michael S. Brown PMCID: PMC509189 CSTX-13, a highly synergistically acting two-chain neurotoxic enhancer in the venom of the spider Cupiennius salei (Ctenidae) Benno Wullschleger, Lucia Kuhn-Nentwig, Jan Tromp, Urs Kämpfer, Johann Schaller, Stefan Schürch, and Wolfgang Nentwig PMCID: PMC509190 CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription Hitomi Nishio and Martin J. Walsh PMCID: PMC509191 Alternate, virus-induced membrane rearrangements support positive-strand RNA virus genome replication Michael Schwartz, Jianbo Chen, Wai-Ming Lee, Michael Janda, and Paul Ahlquist PMCID: PMC509192 Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells Krishna M. Vattem and Ronald C. Wek PMCID: PMC509193 Mapping glycoside hydrolase substrate subsites by isothermal titration calorimetry Gennady Zolotnitsky, Uri Cogan, Noam Adir, Vered Solomon, Gil Shoham, and Yuval Shoham PMCID: PMC509194 Biophysics Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond Evan Evans, Andrew Leung, Volkmar Heinrich, and Cheng Zhu PMCID: PMC509195 Anchor residues in protein–protein interactions Deepa Rajamani, Spencer Thiel, Sandor Vajda, and Carlos J. Camacho PMCID: PMC509196 Watching the photosynthetic apparatus in native membranes Simon Scheuring, James N. Sturgis, Valerie Prima, Alain Bernadac, Daniel Lévy, and Jean-Louis Rigaud PMCID: PMC509197 Nanometer-localized multiple single-molecule fluorescence microscopy Xiaohui Qu, David Wu, Laurens Mets, and Norbert F. Scherer PMCID: PMC509198 G protein-coupled receptors: In silico drug discovery in 3D Oren M. Becker, Yael Marantz, Sharon Shacham, Boaz Inbal, Alexander Heifetz, Ori Kalid, Shay Bar-Haim, Dora Warshaviak, Merav Fichman, and Silvia Noiman PMCID: PMC509175 RNA dynamics in live Escherichia coli cells Ido Golding and Edward C. Cox PMCID: PMC509199 Conformation and orientation of a protein folding intermediate trapped by adsorption Maarten F. M. Engel, Antonie J. W. G. Visser, and Carlo P. M. van Mierlo PMCID: PMC509200 Cell Biology Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome Andreas C. W. Jenke, Isa M. Stehle, Frank Herrmann, Tobias Eisenberger, Armin Baiker, Jürgen Bode, Frank O. Fackelmayer, and Hans J. Lipps PMCID: PMC509201 Small-molecule-based identification of dynamic assembly of E2F–pocket protein–histone deacetylase complex for telomerase regulation in human cells Jaejoon Won, Seungwoo Chang, Sangtaek Oh, and Tae Kook Kim PMCID: PMC509202 Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging Fredrik K. Johansson, Josefin Brodd, Charlotta Eklöf, Maria Ferletta, Göran Hesselager, Carl-Fredrik Tiger, Lene Uhrbom, and Bengt Westermark PMCID: PMC509203 Evolution Venomous protease of aphid soldier for colony defense Mayako Kutsukake, Harunobu Shibao, Naruo Nikoh, Mizue Morioka, Tomohiro Tamura, Tamotsu Hoshino, Satoru Ohgiya, and Takema Fukatsu PMCID: PMC509204 Venezuelan equine encephalitis emergence: Enhanced vector infection from a single amino acid substitution in the envelope glycoprotein Aaron C. Brault, Ann M. Powers, Diana Ortiz, Jose G. Estrada-Franco, Roberto Navarro-Lopez, and Scott C. Weaver PMCID: PMC509205 Reproductive ground plan may mediate colony-level selection effects on individual foraging behavior in honey bees Gro V. Amdam, Kari Norberg, M. Kim Fondrk, and Robert E. Page, Jr. PMCID: PMC509206 Genetic basis for the evolution of vertebrate mineralized tissue Kazuhiko Kawasaki, Tohru Suzuki, and Kenneth M. Weiss PMCID: PMC509207 From the Cover:
Origins of recently gained introns in Caenorhabditis Avril Coghlan and Kenneth H. Wolfe PMCID: PMC509176 Genetics Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas Nicolas Vogt, Sandrine-Hélène Lefèvre, Françoise Apiou, Anne-Marie Dutrillaux, Andrej Cör, Pascal Leuraud, Marie-France Poupon, Bernard Dutrillaux, Michelle Debatisse, and Bernard Malfoy PMCID: PMC509208 Centromeric DNA sequences in the pathogenic yeast Candida albicans are all different and unique Kaustuv Sanyal, Mary Baum, and John Carbon PMCID: PMC509209 Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosis Kentaro Yamashita, Miki Shinohara, and Akira Shinohara PMCID: PMC509210 Immunology From the Cover:
A specific gene expression program triggered by Gram-positive bacteria in the cytosol Ramona L. McCaffrey, Paul Fawcett, Mary O'Riordan, Kyung-Dall Lee, Edward A. Havell, Patrick O. Brown, and Daniel A. Portnoy PMCID: PMC509177 Staphylococcal toxin induced preferential and prolonged in vivo deletion of innate-like B lymphocytes Carl S. Goodyear and Gregg J. Silverman PMCID: PMC509211 Critical role for granulocyte colony-stimulating factor in inflammatory arthritis Kate E. Lawlor, Ian K. Campbell, Donald Metcalf, Kristy O'Donnell, Annemarie van Nieuwenhuijze, Andrew W. Roberts, and Ian P. Wicks PMCID: PMC509212 Carbohydrate mimicry between human ganglioside GM1 and Campylobacter jejuni lipooligosaccharide causes Guillain–Barré syndrome Nobuhiro Yuki, Keiichiro Susuki, Michiaki Koga, Yukihiro Nishimoto, Masaaki Odaka, Koichi Hirata, Kyoji Taguchi, Tadashi Miyatake, Koichi Furukawa, Tetsuji Kobata, and Mitsunori Yamada PMCID: PMC509213 Chromatin landscape dynamics of the Il4–Il13 locus during T helper 1 and 2 development Aurélie Baguet and Mark Bix PMCID: PMC509214 Herpes simplex virus type-1 induces IFN-α production via Toll-like receptor 9-dependent and -independent pathways Hubertus Hochrein, Beatrix Schlatter, Meredith O'Keeffe, Cornelia Wagner, Frank Schmitz, Matthias Schiemann, Stefan Bauer, Mark Suter, and Hermann Wagner PMCID: PMC509215 Translocation of CD28 to lipid rafts and costimulation of IL-2 Ali Sadra, Tomas Cinek, and John B. Imboden PMCID: PMC509216 Medical Sciences Metastatic cancer DNA phenotype identified in normal tissues surrounding metastasizing prostate carcinomas Donald C. Malins, Naomi K. Gilman, Virginia M. Green, Thomas M. Wheeler, Edward A. Barker, Mark A. Vinson, Mohammad Sayeeduddin, Karl Erik Hellström, and Katie M. Anderson PMCID: PMC509217 Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect Emely Castro-Rivera, Sophia Ran, Philip Thorpe, and John D. Minna PMCID: PMC509218 In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia Craig K. Abbey, Alexander D. Borowsky, Erik T. McGoldrick, Jeffrey P. Gregg, Jeannie E. Maglione, Robert D. Cardiff, and Simon R. Cherry PMCID: PMC509219 Mpl Baltimore: A thrombopoietin receptor polymorphism associated with thrombocytosis Alison R. Moliterno, Donna M. Williams, Laura I. Gutierrez-Alamillo, Roberto Salvatori, Roxann G. Ingersoll, and Jerry L. Spivak PMCID: PMC509220 Microbiology From the Cover:
The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor Shinya Kodani, Michael E. Hudson, Marcus C. Durrant, Mark J. Buttner, Justin R. Nodwell, and Joanne M. Willey PMCID: PMC509221 Neuroscience β-Adrenergic modulation of emotional memory-evoked human amygdala and hippocampal responses B. A. Strange and R. J. Dolan PMCID: PMC509222 Pheromone anosmia in a scarab beetle induced by in vivo inhibition of a pheromone-degrading enzyme Martine Maïbèche-Coisne, Alexander A. Nikonov, Yuko Ishida, Emmanuelle Jacquin-Joly, and Walter S. Leal PMCID: PMC509178 Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice Minoru Kobayashi, Ciro Iaccarino, Adolfo Saiardi, Valérie Heidt, Yuri Bozzi, Roberto Picetti, Carmine Vitale, Heiner Westphal, John Drago, and Emiliana Borrelli PMCID: PMC509223 Pharmacology Cardioprotective effects of thioredoxin in myocardial ischemia and the reperfusion role of S-nitrosation Ling Tao, Erhe Gao, Nathan S. Bryan, Yan Qu, Hui-Rong Liu, Aihua Hu, Theodore A. Christopher, Bernard L. Lopez, Junji Yodoi, Walter J. Koch, Martin Feelisch, and Xin L. Ma PMCID: PMC509224 Physiology Biological activity of nitric oxide in the plasmatic compartment Xunde Wang, Jose E. Tanus-Santos, Christopher D. Reiter, Andre Dejam, Sruti Shiva, Reginald D. Smith, Neil Hogg, and Mark T. Gladwin PMCID: PMC509225 Sphingosine 1-phosphate activates Weibel-Palade body exocytosis Kenji Matsushita, Craig N. Morrell, and Charles J. Lowenstein PMCID: PMC509226 Tissue remodeling of rat pulmonary arteries in recovery from hypoxic hypertension Zhuangjie Li, Wei Huang, Zong Lai Jiang, Hans Gregersen, and Yuan-Cheng Fung PMCID: PMC509227 Plant Biology Transcriptional repression of target genes by LEUNIG and SEUSS, two interacting regulatory proteins for Arabidopsis flower development Vaniyambadi V. Sridhar, Anandkumar Surendrarao, Deyarina Gonzalez, R. Steven Conlan, and Zhongchi Liu PMCID: PMC509228 Heterodimerization of type II phytochromes in Arabidopsis Robert A. Sharrock and Ted Clack PMCID: PMC509229 Nitrate assimilation in plant shoots depends on photorespiration Shimon Rachmilevitch, Asaph B. Cousins, and Arnold J. Bloom PMCID: PMC509230 Detection of 91 potential conserved plant microRNAs in Arabidopsis thaliana and Oryza sativa identifies important target genes Eric Bonnet, Jan Wuyts, Pierre Rouzé, and Yves Van de Peer PMCID: PMC509231 Social Sciences Economic Sciences Sampling design for an integrated socioeconomic and ecological survey by using satellite remote sensing and ordination Michael W. Binford, Tae Jeong Lee, and Robert M. Townsend PMCID: PMC509232 The educative impact of health care treatment on malarial prevention behavior for the poor in Guinea, West Africa Daniel L. McFadden and Vasu Sunkara PMCID: PMC509233 Correction Proc Natl Acad Sci U S A. 2004 August 3; 101(31): 11526. Published online 2004 July 14. doi: 10.1073/pnas.0403553101.PMCID: PMC509234 Corrects: Frédérique Bard, et al. Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proc Natl Acad Sci U S A. 2003 February 18; 100(4): 2023–2028. |
