| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 June 13; 103(24): 8907–8908. doi: 10.1073/pnas.iti2406103.PMCID: PMC1482535 Commentaries Steroid hormone secretion in insects comes of age James W. Truman PMCID: PMC1482536 Myosin's mechanical ratchet Robert A. Cross PMCID: PMC1482537 Inducing endogenous antimicrobial peptides to battle infections Michael Zasloff PMCID: PMC1482538 Profiles Profile of Andrew R. Marks Philip Downey PMCID: PMC1482539 Profile of Alec J. Jeffreys Nick Zagorski PMCID: PMC1482540 Physical Sciences Applied Mathematics A constant production hypothesis guides leaf venation patterning Pavel Dimitrov and Steven W. Zucker PMCID: PMC1474015 Applied Physical Sciences Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure Praveen R. Arany, Kathleen C. Flanders, Tetsu Kobayashi, Catherine K. Kuo, Christina Stuelten, Kartiki V. Desai, Rocky Tuan, Stephen I. Rennard, and Anita B. Roberts PMCID: PMC1474013 Chemistry Cu-catalyzed cross-dehydrogenative coupling: A versatile strategy for C–C bond formations via the oxidative activation of sp3 C–H bonds Zhiping Li, D. Scott Bohle, and Chao-Jun Li PMCID: PMC1482542 Experimental and computational probes of the space in a self-assembled capsule Dariush Ajami, Tetsuo Iwasawa, and Julius Rebek, Jr. PMCID: PMC1482543 Geology Solar modulation of Little Ice Age climate in the tropical Andes P. J. Polissar, M. B. Abbott, A. P. Wolfe, M. Bezada, V. Rull, and R. S. Bradley PMCID: PMC1482544 Physics Multiple self-localized electronic states in trans-polyacetylene Xi Lin, Ju Li, Clemens J. Först, and Sidney Yip PMCID: PMC1482545 Observation of fragile-to-strong dynamic crossover in protein hydration water S.-H. Chen, L. Liu, E. Fratini, P. Baglioni, A. Faraone, and E. Mamontov PMCID: PMC1482557 Biological Sciences Biochemistry Dimeric organization of the yeast oligosaccharyl transferase complex Manasi Chavan, Zhiqiang Chen, Guangtao Li, Hermann Schindelin, William J. Lennarz, and Huilin Li PMCID: PMC1482546 Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage Karin C. Nitiss, Mobeen Malik, Xiaoping He, Stephen W. White, and John L. Nitiss PMCID: PMC1482547 Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry Pedro R. Cutillas, Asim Khwaja, Mariona Graupera, Wayne Pearce, Severine Gharbi, Mike Waterfield, and Bart Vanhaesebroeck PMCID: PMC1482548 Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis Zhe Liu, Hao Lin, Sheng Ye, Qin-ying Liu, Zhaohui Meng, Chuan-mao Zhang, Yongjing Xia, Emanuel Margoliash, Zihe Rao, and Xiang-jun Liu PMCID: PMC1482549 The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G2/M phase rather than S phase Lauren S. Waters and Graham C. Walker PMCID: PMC1482550 Convergence of isoprene and polyketide biosynthetic machinery: Isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis Christopher T. Calderone, Walter E. Kowtoniuk, Neil L. Kelleher, Christopher T. Walsh, and Pieter C. Dorrestein PMCID: PMC1482551 Essential and mutually compensatory roles of α-mannosidase II and α-mannosidase IIx in N-glycan processing in vivo in mice Tomoya O. Akama, Hiroaki Nakagawa, Nyet Kui Wong, Mark Sutton-Smith, Anne Dell, Howard R. Morris, Jun Nakayama, Shin-Ichiro Nishimura, Ashok Pai, Kelley W. Moremen, Jamey D. Marth, and Michiko N. Fukuda PMCID: PMC1474017 Semirational design of Jun-Fos coiled coils with increased affinity: Universal implications for leucine zipper prediction and design Jody M. Mason, Mark A. Schmitz, Kristian M. Müller, and Katja M. Arndt PMCID: PMC1482553 Endonuclease G: A role for the enzyme in recombination and cellular proliferation Ke-Jung Huang, Chia-Chi Ku, and I. Robert Lehman PMCID: PMC1482554 Biophysics Microfibrillar structure of type I collagen in situ Joseph P. R. O. Orgel, Thomas C. Irving, Andrew Miller, and Tim J. Wess PMCID: PMC1473175 Differential detection of dual traps improves the spatial resolution of optical tweezers Jeffrey R. Moffitt, Yann R. Chemla, David Izhaky, and Carlos Bustamante PMCID: PMC1482556 Observation of fragile-to-strong dynamic crossover in protein hydration water S.-H. Chen, L. Liu, E. Fratini, P. Baglioni, A. Faraone, and E. Mamontov PMCID: PMC1482557 Cell Biology Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis John R. Basile, Rogerio M. Castilho, Vanessa P. Williams, and J. Silvio Gutkind PMCID: PMC1482558 GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis Lei Xu, Shahinoor Begum, Jeremy D. Hearn, and Richard O. Hynes PMCID: PMC1474142 Redox sensor CtBP mediates hypoxia-induced tumor cell migration Qinghong Zhang, Su-Yan Wang, Amanda C. Nottke, Jonathan V. Rocheleau, David W. Piston, and Richard H. Goodman PMCID: PMC1482560 Centrosome-associated RNA in surf clam oocytes Mark C. Alliegro, Mary Anne Alliegro, and Robert E. Palazzo PMCID: PMC1482561 A mammalian NudC-like protein essential for dynein stability and cell viability Tianhua Zhou, Wendy Zimmerman, Xiaoqi Liu, and Raymond L. Erikson PMCID: PMC1482562 Compartmentalized signaling of Ras in fission yeast Brian Onken, Heidi Wiener, Mark R. Philips, and Eric C. Chang PMCID: PMC1482563 Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a Han You, Kazuo Yamamoto, and Tak Wah Mak PMCID: PMC1482564 Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells Carl R. Walkley and Stuart H. Orkin PMCID: PMC1474009 A variant of estrogen receptor-α, hER-α36: Transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling ZhaoYi Wang, XinTian Zhang, Peng Shen, Brian W. Loggie, YunChao Chang, and Thomas F. Deuel PMCID: PMC1482566 Developmental Biology Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear Yukako Asai, Dylan K. Chan, Catherine J. Starr, James A. Kappler, Richard Kollmar, and A. J. Hudspeth PMCID: PMC1474007 Generation of the primary hair follicle pattern Chunyan Mou, Ben Jackson, Pascal Schneider, Paul A. Overbeek, and Denis J. Headon PMCID: PMC1482568 Interspecies difference in the regulation of melanocyte development by SOX10 and MITF Ling Hou, Heinz Arnheiter, and William J. Pavan PMCID: PMC1482569 Environmental Sciences Biomass and toxicity responses of poison ivy (Toxicodendron radicans) to elevated atmospheric CO2 Jacqueline E. Mohan, Lewis H. Ziska, William H. Schlesinger, Richard B. Thomas, Richard C. Sicher, Kate George, and James S. Clark PMCID: PMC1474014 Evolution Experimental evidence that predation promotes divergence in adaptive radiation Patrik Nosil and Bernard J. Crespi PMCID: PMC1482571 From the Cover:
Naked corals: Skeleton loss in Scleractinia Mónica Medina, Allen G. Collins, Tori L. Takaoka, Jennifer V. Kuehl, and Jeffrey L. Boore PMCID: PMC1482572 Phylogenetic analysis of the “ECE” (CYC/TB1) clade reveals duplications predating the core eudicots Dianella G. Howarth and Michael J. Donoghue PMCID: PMC1482573 Tests of parallel molecular evolution in a long-term experiment with Escherichia coli Robert Woods, Dominique Schneider, Cynthia L. Winkworth, Margaret A. Riley, and Richard E. Lenski PMCID: PMC1482574 The group covariance effect and fitness trade-offs during evolutionary transitions in individuality Richard E. Michod PMCID: PMC1482575 Positive selection driving diversification in plant secondary metabolism Markus Benderoth, Susanne Textor, Aaron J. Windsor, Thomas Mitchell-Olds, Jonathan Gershenzon, and Juergen Kroymann PMCID: PMC1482576 Timing and rate of speciation in Agave (Agavaceae) Sara V. Good-Avila, Valeria Souza, Brandon S. Gaut, and Luis E. Eguiarte PMCID: PMC1482577 Kinetic effects of temperature on rates of genetic divergence and speciation Andrew P. Allen, James F. Gillooly, Van M. Savage, and James H. Brown PMCID: PMC1474011 Genetics INAUGURAL ARTICLE by a Recently Elected Academy Member: Processes of copy-number change in human DNA: The dynamics of α-globin gene deletion Kwan-Wood G. Lam and Alec J. Jeffreys PMCID: PMC1482541 microRNAs exhibit high frequency genomic alterations in human cancer Lin Zhang, Jia Huang, Nuo Yang, Joel Greshock, Molly S. Megraw, Antonis Giannakakis, Shun Liang, Tara L. Naylor, Andrea Barchetti, Michelle R. Ward, George Yao, Angelica Medina, Ann O’Brien-Jenkins, Dionyssios Katsaros, Artemis Hatzigeorgiou, Phyllis A. Gimotty, Barbara L. Weber, and George Coukos PMCID: PMC1474008 Ectodysplasin regulates the lymphotoxin-β pathway for hair differentiation Chang-Yi Cui, Tsuyoshi Hashimoto, Sergei I. Grivennikov, Yulan Piao, Sergei A. Nedospasov, and David Schlessinger PMCID: PMC1482580 Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence Angela J. Frodsham, Lyna Zhang, Uga Dumpis, Nor Azizah Mohd Taib, Steve Best, Andrew Durham, Branwen J. W. Hennig, Simon Hellier, Susanne Knapp, Mark Wright, Maria Chiaramonte, John I. Bell, Mary Graves, Hilton C. Whittle, Howard C. Thomas, Mark R. Thursz, and Adrian V. S. Hill PMCID: PMC1482581 Nascent DNA processing by RecJ favors lesion repair over translesion synthesis at arrested replication forks in Escherichia coli Charmain T. Courcelle, Kin-Hoe Chow, Andrew Casey, and Justin Courcelle PMCID: PMC1482582 Immunology A unique lymphotoxin αβ-dependent pathway regulates thymic emigration of Vα14 invariant natural killer T cells Ann Sophie Franki, Katrien Van Beneden, Pieter Dewint, Kirsten J. L. Hammond, Stijn Lambrecht, Georges Leclercq, Mitchell Kronenberg, Dieter Deforce, and Dirk Elewaut PMCID: PMC1482583 Converting IL-15 to a superagonist by binding to soluble IL-15Rα Mark P. Rubinstein, Marek Kovar, Jared F. Purton, Jae-Ho Cho, Onur Boyman, Charles D. Surh, and Jonathan Sprent PMCID: PMC1482584 Mapping epitopes and antigenicity by site-directed masking Didrik Paus and Greg Winter PMCID: PMC1482585 From the Cover:
Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic Rubhana Raqib, Protim Sarker, Peter Bergman, Gul Ara, Monica Lindh, David A. Sack, K. M. Nasirul Islam, Gudmundur H. Gudmundsson, Jan Andersson, and Birgitta Agerberth PMCID: PMC1482586 Early establishment of diverse T cell receptor profiles for influenza-specific CD8+CD62Lhi memory T cells Katherine Kedzierska, Vanessa Venturi, Kenneth Field, Miles P. Davenport, Stephen J. Turner, and Peter C. Doherty PMCID: PMC1482587 Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity Masahisa Jinushi, F. Stephen Hodi, and Glenn Dranoff PMCID: PMC1482588 Trif-related adapter molecule is phosphorylated by PKCε during Toll-like receptor 4 signaling Anne F. McGettrick, Elizabeth K. Brint, Eva M. Palsson-McDermott, Daniel C. Rowe, Douglas T. Golenbock, Nicholas J. Gay, Katherine A. Fitzgerald, and Luke A. J. O'Neill PMCID: PMC1482589 Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance Ian A. York, Michael A. Brehm, Sophia Zendzian, Charles F. Towne, and Kenneth L. Rock PMCID: PMC1482590 Medical Sciences A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth Lars Holmgren, Elena Ambrosino, Olivier Birot, Carl Tullus, Niina Veitonmäki, Tetyana Levchenko, Lena-Maria Carlson, Piero Musiani, Manuela Iezzi, Claudia Curcio, Guido Forni, Federica Cavallo, and Rolf Kiessling PMCID: PMC1482591 Neutralization epitope responsible for the hepatitis B virus subtype-specific protection in chimpanzees Pei Zhang, Mei-ying W. Yu, Richard Venable, Harvey J. Alter, and J. Wai-Kou Shih PMCID: PMC1474144 The role of NF-κB-1 and NF-κB-2-mediated resistance to apoptosis in lymphomas Leon Bernal-Mizrachi, Christine M. Lovly, and Lee Ratner PMCID: PMC1482593 From the Cover:
Stem cell niches in the adult mouse heart Konrad Urbanek, Daniela Cesselli, Marcello Rota, Angelo Nascimbene, Antonella De Angelis, Toru Hosoda, Claudia Bearzi, Alessandro Boni, Roberto Bolli, Jan Kajstura, Piero Anversa, and Annarosa Leri PMCID: PMC1474010 Estrogens protect pancreatic β-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice Cedric Le May, Khoi Chu, Min Hu, Christina S. Ortega, Evan R. Simpson, Kenneth S. Korach, Ming-Jer Tsai, and Franck Mauvais-Jarvis PMCID: PMC1482595 Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization Jun Zhou, Laurent Pérès, Nicole Honoré, Rihab Nasr, Jun Zhu, and Hugues de Thé PMCID: PMC1474145 Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance Mohammad Azam, Valentina Nardi, William C. Shakespeare, Chester A. Metcalf, III, Regine S. Bohacek, Yihan Wang, Raji Sundaramoorthi, Piotr Sliz, Darren R. Veach, William G. Bornmann, Bayard Clarkson, David C. Dalgarno, Tomi K. Sawyer, and George Q. Daley PMCID: PMC1482597 Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure Praveen R. Arany, Kathleen C. Flanders, Tetsu Kobayashi, Catherine K. Kuo, Christina Stuelten, Kartiki V. Desai, Rocky Tuan, Stephen I. Rennard, and Anita B. Roberts PMCID: PMC1474013 Synergic effect of polymorphisms in ERCC6 5′ flanking region and complement factor H on age-related macular degeneration predisposition Jingsheng Tuo, Baitang Ning, Christine M. Bojanowski, Zhong-Ning Lin, Robert J. Ross, George F. Reed, Defen Shen, Xiaodong Jiao, Min Zhou, Emily Y. Chew, Fred F. Kadlubar, and Chi-Chao Chan PMCID: PMC1474016 From the Cover:
Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice Apostolos Klinakis, Matthias Szabolcs, Katerina Politi, Hippokratis Kiaris, Spyros Artavanis-Tsakonas, and Argiris Efstratiadis PMCID: PMC1570422 Microbiology From the Cover:
Histamine signaling through the H2 receptor in the Peyer’s patch is important for controlling Yersinia enterocolitica infection Scott A. Handley, Peter H. Dube, and Virginia L. Miller PMCID: PMC1482599 The complete genome sequence of Lactobacillus bulgaricus reveals extensive and ongoing reductive evolution M. van de Guchte, S. Penaud, C. Grimaldi, V. Barbe, K. Bryson, P. Nicolas, C. Robert, S. Oztas, S. Mangenot, A. Couloux, V. Loux, R. Dervyn, R. Bossy, A. Bolotin, J.-M. Batto, T. Walunas, J.-F. Gibrat, P. Bessières, J. Weissenbach, S. D. Ehrlich, and E. Maguin PMCID: PMC1482600 A Vibrio cholerae protease needed for killing of Caenorhabditis elegans has a role in protection from natural predator grazing Karolis Vaitkevicius, Barbro Lindmark, Gangwei Ou, Tianyan Song, Claudia Toma, Masaaki Iwanaga, Jun Zhu, Agneta Andersson, Marie-Louise Hammarström, Simon Tuck, and Sun Nyunt Wai PMCID: PMC1482601 The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparum Kamal El Bissati, Rachel Zufferey, William H. Witola, Nicola S. Carter, Buddy Ullman, and Choukri Ben Mamoun PMCID: PMC1482602 Conformational suppression of inter-receptor signaling defects Peter Ames and John S. Parkinson PMCID: PMC1482603 Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel Martin E. Lidell, Darcy M. Moncada, Kris Chadee, and Gunnar C. Hansson PMCID: PMC1482604 Neuroscience Imaging of CNS myelin by positron-emission tomography Bruno Stankoff, Yanming Wang, Michel Bottlaender, Marie-Stephane Aigrot, Frederic Dolle, Chunying Wu, Douglas Feinstein, Guo-Feng Huang, Frank Semah, Chester A. Mathis, William Klunk, Robert M. Gould, Catherine Lubetzki, and Bernard Zalc PMCID: PMC1482605 Ric-8B promotes functional expression of odorant receptors Luiz Eduardo C. Von Dannecker, Adriana F. Mercadante, and Bettina Malnic PMCID: PMC1482606 Neurocognitive development of the ability to manipulate information in working memory Eveline A. Crone, Carter Wendelken, Sarah Donohue, Linda van Leijenhorst, and Silvia A. Bunge PMCID: PMC1472660 Purinergic signaling induces thrombospondin-1 expression in astrocytes Minh D. Tran and Joseph T. Neary PMCID: PMC1482608 The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase–response curve amplitude Martha Hotz Vitaterna, Caroline H. Ko, Anne-Marie Chang, Ethan D. Buhr, Ethan M. Fruechte, Andrew Schook, Marina P. Antoch, Fred W. Turek, and Joseph S. Takahashi PMCID: PMC1474012 Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter Rong Chen, Michael R. Tilley, Hua Wei, Fuwen Zhou, Fu-Ming Zhou, San Ching, Ning Quan, Robert L. Stephens, Erik R. Hill, Timothy Nottoli, Dawn D. Han, and Howard H. Gu PMCID: PMC1482610 Neuroanatomical evidence for segregation of nerve fibers conveying light touch and pain sensation in Eimer’s organ of the mole Paul D. Marasco, Pamela R. Tsuruda, Diana M. Bautista, David Julius, and Kenneth C. Catania PMCID: PMC1482611 Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington’s disease Jodi L. McBride, Shilpa Ramaswamy, Mehdi Gasmi, Raymond T. Bartus, Christopher D. Herzog, Eugene P. Brandon, Lili Zhou, Mark R. Pitzer, Elizabeth M. Berry-Kravis, and Jeffrey H. Kordower PMCID: PMC1482612 Item memory, source memory, and the medial temporal lobe: Concordant findings from fMRI and memory-impaired patients Jeffrey J. Gold, Christine N. Smith, Peter J. Bayley, Yael Shrager, James B. Brewer, Craig E. L. Stark, Ramona O. Hopkins, and Larry R. Squire PMCID: PMC1482613 Physiology Genome-wide RNAi screen of Ca2+ influx identifies genes that regulate Ca2+ release-activated Ca2+ channel activity Shenyuan L. Zhang, Andriy V. Yeromin, Xiang H.-F. Zhang, Ying Yu, Olga Safrina, Aubin Penna, Jack Roos, Kenneth A. Stauderman, and Michael D. Cahalan PMCID: PMC1482614 Plant Biology A constant production hypothesis guides leaf venation patterning Pavel Dimitrov and Steven W. Zucker PMCID: PMC1474015 Social Sciences Psychology Predicting short-term stock fluctuations by using processing fluency Adam L. Alter and Daniel M. Oppenheimer PMCID: PMC1482615 Corrections Correction for Gavin et al., Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development PMCID: PMC1482616 Corrects: Marc A. Gavin, et al. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci U S A. 2006 April 25; 103(17): 6659–6664. Correction for Fraser et al., Hypoxia-inducible myoglobin expression in nonmuscle tissues Jane Fraser, Luciane Vieira de Mello, Deborah Ward, Huw H. Rees, Daryl R. Williams, Yongxiang Fang, Andrew Brass, Andrew Y. Gracey, and Andrew R. Cossins PMCID: PMC1482617 Corrects: Jane Fraser, et al. From The Cover:
Hypoxia-inducible myoglobin expression in nonmuscle tissues. Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2977–2981. Correction for Guo et al., Long-range multilocus haplotype phasing of the MHC PMCID: PMC1482618 Corrects: Zhen Guo, et al. Long-range multilocus haplotype phasing of the MHC. Proc Natl Acad Sci U S A. 2006 May 2; 103(18): 6964–6969. Correction for Xie et al., Insights into TOR function and rapamycin response: Chemical genomic profiling by using a high-density cell array method PMCID: PMC1482619 Corrects: Michael W. Xie, et al. Insights into TOR function and rapamycin response: Chemical genomic profiling by using a high-density cell array method. Proc Natl Acad Sci U S A. 2005 May 17; 102(20): 7215–7220. |
