| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 June 20; 103(25): 9375–9376. doi: 10.1073/iti2506103.PMCID: PMC1480413 Commentaries The systems biology of infection in animal models bears fruit Lucas R. Hoffman and Samuel I. Miller PMCID: PMC1480414 The tiny enslaved genome of a rhizarian alga Thomas Cavalier-Smith PMCID: PMC1480415 Perspective Why did modern human populations disperse from Africa ca. 60,000 years ago? A new model Paul Mellars PMCID: PMC1480416 Profile Profile of Steven C. Hebert Bijal P. Trivedi PMCID: PMC1480417 Physical Sciences Applied Mathematics Helices Nadia Chouaieb, Alain Goriely, and John H. Maddocks PMCID: PMC1480419 Network motif identification in stochastic networks Rui Jiang, Zhidong Tu, Ting Chen, and Fengzhu Sun PMCID: PMC1480420 Chemistry Spatiotemporal reaction kinetics of an ultrafast photoreaction pathway visualized by time-resolved liquid x-ray diffraction Tae Kyu Kim, Maciej Lorenc, Jae Hyuk Lee, Manuela Lo Russo, Joonghan Kim, Marco Cammarata, Qingyu Kong, Sylvie Noel, Anton Plech, Michael Wulff, and Hyotcherl Ihee PMCID: PMC1478163 Design of metal cofactors activated by a protein–protein electron transfer system Takafumi Ueno, Norihiko Yokoi, Masaki Unno, Toshitaka Matsui, Yuichi Tokita, Masako Yamada, Masao Ikeda-Saito, Hiroshi Nakajima, and Yoshihito Watanabe PMCID: PMC1480422 From the Cover:
Hydrogen chloride-induced surface disordering on ice V. Faye McNeill, Thomas Loerting, Franz M. Geiger, Bernhardt L. Trout, and Mario J. Molina PMCID: PMC1480423 Membrane protein dynamics and detergent interactions within a crystal: A simulation study of OmpA Peter J. Bond, José D. Faraldo-Gómez, Sundeep S. Deol, and Mark S. P. Sansom PMCID: PMC1480439 Engineering Novel nanocomposites from spider silk–silica fusion (chimeric) proteins Cheryl Wong Po Foo, Siddharth V. Patwardhan, David J. Belton, Brandon Kitchel, Daphne Anastasiades, Jia Huang, Rajesh R. Naik, Carole C. Perry, and David L. Kaplan PMCID: PMC1476692 Mechanics-based statistics of failure risk of quasibrittle structures and size effect on safety factors Zdeněk P. Bažant and Sze-Dai Pang PMCID: PMC1480425 Geology Nanoscale detection of organic signatures in carbonate microbialites Karim Benzerara, Nicolas Menguy, Purificación López-García, Tae-Hyun Yoon, Józef Kazmierczak, Tolek Tyliszczak, François Guyot, and Gordon E. Brown, Jr. PMCID: PMC1480426 Physics Flexible phenylalanine-glycine nucleoporins as entropic barriers to nucleocytoplasmic transport Roderick Y. H. Lim, Ning-Ping Huang, Joachim Köser, Jie Deng, K. H. Aaron Lau, Kyrill Schwarz-Herion, Birthe Fahrenkrog, and Ueli Aebi PMCID: PMC1480438 Statistics Quantitative exploration of the occurrence of lateral gene transfer by using nitrogen fixation genes as a case study Katherina J. Kechris, Jason C. Lin, Peter J. Bickel, and Alexander N. Glazer PMCID: PMC1480450 Biological Sciences Applied Biological Sciences Identification of bifunctional Δ12/ω3 fatty acid desaturases for improving the ratio of ω3 to ω6 fatty acids in microbes and plants Howard G. Damude, Hongxiang Zhang, Leonard Farrall, Kevin G. Ripp, Jean-Francois Tomb, Dieter Hollerbach, and Narendra S. Yadav PMCID: PMC1480427 Biochemistry The intricate side of systems biology Eberhard Voit, Ana Rute Neves, and Helena Santos PMCID: PMC1480428 Leishmania β-1,2-mannan is assembled on a mannose-cyclic phosphate primer M. Fleur Sernee, Julie E. Ralton, Zoran Dinev, George N. Khairallah, Richard A. O’Hair, Spencer J. Williams, and Malcolm J. McConville PMCID: PMC1480429 The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation Franziska Bleichert, Sander Granneman, Yvonne N. Osheim, Ann L. Beyer, and Susan J. Baserga PMCID: PMC1480430 Structural basis of catalysis by monometalated methionine aminopeptidase Qi-Zhuang Ye, Sheng-Xue Xie, Ze-Qiang Ma, Min Huang, and Robert P. Hanzlik PMCID: PMC1480431 Human methionine synthase reductase is a molecular chaperone for human methionine synthase Kazuhiro Yamada, Roy A. Gravel, Tetsuo Toraya, and Rowena G. Matthews PMCID: PMC1480432 Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT) Daniela C. Dieterich, A. James Link, Johannes Graumann, David A. Tirrell, and Erin M. Schuman PMCID: PMC1480433 Ribosomal shunting mediated by a translational enhancer element that base pairs to 18S rRNA Stephen A. Chappell, John Dresios, Gerald M. Edelman, and Vincent P. Mauro PMCID: PMC1480434 A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding Muhammad M. Karim, Yuri V. Svitkin, Avak Kahvejian, Gregory De Crescenzo, Mauro Costa-Mattioli, and Nahum Sonenberg PMCID: PMC1480435 Calcium dependence of aequorin bioluminescence dissected by random mutagenesis Ludovic Tricoire, Keisuke Tsuzuki, Olivier Courjean, Nathalie Gibelin, Gaëlle Bourout, Jean Rossier, and Bertrand Lambolez PMCID: PMC1480436 A Mediator-responsive form of metazoan RNA polymerase II Xiaopeng Hu, Sohail Malik, Costin Catalin Negroiu, Kyle Hubbard, Chidambaram Natesa Velalar, Brian Hampton, Dan Grosu, Jennifer Catalano, Robert G. Roeder, and Averell Gnatt PMCID: PMC1480437 Biophysics Helices Nadia Chouaieb, Alain Goriely, and John H. Maddocks PMCID: PMC1480419 Flexible phenylalanine-glycine nucleoporins as entropic barriers to nucleocytoplasmic transport Roderick Y. H. Lim, Ning-Ping Huang, Joachim Köser, Jie Deng, K. H. Aaron Lau, Kyrill Schwarz-Herion, Birthe Fahrenkrog, and Ueli Aebi PMCID: PMC1480438 Membrane protein dynamics and detergent interactions within a crystal: A simulation study of OmpA Peter J. Bond, José D. Faraldo-Gómez, Sundeep S. Deol, and Mark S. P. Sansom PMCID: PMC1480439 Cell Biology From the Cover:
Identifying genes important for spermatogonial stem cell self-renewal and survival Jon M. Oatley, Mary R. Avarbock, Aino I. Telaranta, Douglas T. Fearon, and Ralph L. Brinster PMCID: PMC1480440 Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro Thai-Yen Ling, Ming-Der Kuo, Chung-Leung Li, Alice L. Yu, Yen-Hua Huang, Tsai-Jung Wu, You-Chin Lin, Shu-Hwa Chen, and John Yu PMCID: PMC1480441 Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B G. M. Rivera, S. Antoku, S. Gelkop, N. Y. Shin, S. K. Hanks, T. Pawson, and B. J. Mayer PMCID: PMC1476694 IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3− cotransporter 1 (pNBC1) Kyoko Shirakabe, Giuseppina Priori, Hideomi Yamada, Hideaki Ando, Shoko Horita, Toshiro Fujita, Ichiro Fujimoto, Akihiro Mizutani, George Seki, and Katsuhiko Mikoshiba PMCID: PMC1480443 Phosphorylation by PKA potentiates retinoic acid receptor α activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7 Emilie Gaillard, Nathalie Bruck, Yann Brelivet, Gaétan Bour, Sébastien Lalevée, Annie Bauer, Olivier Poch, Dino Moras, and Cécile Rochette-Egly PMCID: PMC1480444 Developmental Biology Neural conversion of ES cells by an inductive activity on human amniotic membrane matrix Morio Ueno, Michiru Matsumura, Kiichi Watanabe, Takahiro Nakamura, Fumitaka Osakada, Masayo Takahashi, Hiroshi Kawasaki, Shigeru Kinoshita, and Yoshiki Sasai PMCID: PMC1480445 Environmental Sciences Variation in the sensitivity of organismal body temperature to climate change over local and geographic scales Sarah E. Gilman, David S. Wethey, and Brian Helmuth PMCID: PMC1480446 Evolution From the Cover:
Complete nucleotide sequence of the chlorarachniophyte nucleomorph: Nature’s smallest nucleus Paul R. Gilson, Vanessa Su, Claudio H. Slamovits, Michael E. Reith, Patrick J. Keeling, and Geoffrey I. McFadden PMCID: PMC1480447 Membrane transporters in the relict plastid of malaria parasites Kylie A. Mullin, Liting Lim, Stuart A. Ralph, Timothy P. Spurck, Emanuela Handman, and Geoffrey I. McFadden PMCID: PMC1480448 From the Cover:
Phylogeography of Asian wild rice, Oryza rufipogon, reveals multiple independent domestications of cultivated rice, Oryza sativa Jason P. Londo, Yu-Chung Chiang, Kuo-Hsiang Hung, Tzen-Yuh Chiang, and Barbara A. Schaal PMCID: PMC1480449 Quantitative exploration of the occurrence of lateral gene transfer by using nitrogen fixation genes as a case study Katherina J. Kechris, Jason C. Lin, Peter J. Bickel, and Alexander N. Glazer PMCID: PMC1480450 Fitness cost of LINE-1 (L1) activity in humans Stephane Boissinot, Jerel Davis, Ali Entezam, Dimitri Petrov, and Anthony V. Furano PMCID: PMC1480451 Genetics Network motif identification in stochastic networks Rui Jiang, Zhidong Tu, Ting Chen, and Fengzhu Sun PMCID: PMC1480420 Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities R. S. Devon, P. C. Orban, K. Gerrow, M. A. Barbieri, C. Schwab, L. P. Cao, J. R. Helm, N. Bissada, R. Cruz-Aguado, T.-L. Davidson, J. Witmer, M. Metzler, C. K. Lam, W. Tetzlaff, E. M. Simpson, J. M. McCaffery, A. E. El-Husseini, B. R. Leavitt, and M. R. Hayden PMCID: PMC1480452 Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm A. J. Wyrobek, B. Eskenazi, S. Young, N. Arnheim, I. Tiemann-Boege, E. W. Jabs, R. L. Glaser, F. S. Pearson, and D. Evenson PMCID: PMC1480453 Two levels of interference in mouse meiotic recombination Esther de Boer, Piet Stam, Axel J. J. Dietrich, Albert Pastink, and Christa Heyting PMCID: PMC1475796 Cockayne syndrome group B protein (CSB) plays a general role in chromatin maintenance and remodeling John C. Newman, Arnold D. Bailey, and Alan M. Weiner PMCID: PMC1480455 Immunology Nonviral Aβ DNA vaccine therapy against Alzheimer’s disease: Long-term effects and safety Yoshio Okura, Akira Miyakoshi, Kuniko Kohyama, Il-Kwon Park, Matthias Staufenbiel, and Yoh Matsumoto PMCID: PMC1480456 A conformational change senses the strength of T cell receptor–ligand interaction during thymic selection Ruth M. Risueño, Hisse M. van Santen, and Balbino Alarcón PMCID: PMC1480457 The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells Wook-Jin Chae, Octavian Henegariu, Sang-Kyou Lee, and Alfred L. M. Bothwell PMCID: PMC1480458 Medical Sciences Isolation of anti-CD22 Fv with high affinity by Fv display on human cells Mitchell Ho, Satoshi Nagata, and Ira Pastan PMCID: PMC1480459 The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases Ahmed Boucharaba, Claire-Marie Serre, Julien Guglielmi, Jean-Claude Bordet, Philippe Clézardin, and Olivier Peyruchaud PMCID: PMC1480460 Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice M. C. Pickering, J. Warren, K. L. Rose, F. Carlucci, Y. Wang, M. J. Walport, H. T. Cook, and M. Botto PMCID: PMC1476693 Upgrading antibiotic use within a class: Tradeoff between resistance and treatment success Y. Claire Wang and Marc Lipsitch PMCID: PMC1480462 Microbiology Amplification of the entire kanamycin biosynthetic gene cluster during empirical strain improvement of Streptomyces kanamyceticus Koji Yanai, Takeshi Murakami, and Mervyn Bibb PMCID: PMC1475798 Shiga toxin of enterohemorrhagic Escherichia coli type O157:H7 promotes intestinal colonization Cory M. Robinson, James F. Sinclair, Michael J. Smith, and Alison D. O’Brien PMCID: PMC1475797 Neuroscience An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice Sylvie Le Corre, Hans W. Klafki, Nikolaus Plesnila, Gabriele Hübinger, Axel Obermeier, Heidi Sahagún, Barbara Monse, Pierfausto Seneci, Jada Lewis, Jason Eriksen, Cynthia Zehr, Mei Yue, Eileen McGowan, Dennis W. Dickson, Michael Hutton, and Hanno M. Roder PMCID: PMC1480465 Glycine receptors regulate interneuron differentiation during spinal network development Jonathan R. McDearmid, Meijiang Liao, and Pierre Drapeau PMCID: PMC1480466 Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations Conrad C. Alano, Tiina M. Kauppinen, Andreu Viader Valls, and Raymond A. Swanson PMCID: PMC1480467 Knockin mice expressing fluorescent δ-opioid receptors uncover G protein-coupled receptor dynamics in vivo Grégory Scherrer, Petra Tryoen-Tóth, Dominique Filliol, Audrey Matifas, Delphine Laustriat, Yu Q. Cao, Allan I. Basbaum, Andrée Dierich, Jean-Luc Vonesh, Claire Gavériaux-Ruff, and Brigitte L. Kieffer PMCID: PMC1480468 Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate Lidong Liu, Paige Cundiff, Glen Abel, Yupeng Wang, Roland Faigle, Hiroyuki Sakagami, Mei Xu, and Zhengui Xia PMCID: PMC1480469 Circadian organization of the mammalian retina Guo-Xiang Ruan, Dao-Qi Zhang, Tongrong Zhou, Shin Yamazaki, and Douglas G. McMahon PMCID: PMC1480470 Interlaced x-ray microplanar beams: A radiosurgery approach with clinical potential F. Avraham Dilmanian, Zhong Zhong, Tigran Bacarian, Helene Benveniste, Pantaleo Romanelli, Ruiliang Wang, Jeremy Welwart, Tetsuya Yuasa, Eliot M. Rosen, and David J. Anschel PMCID: PMC1480471 Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in central amygdala Marisa Roberto and George R. Siggins PMCID: PMC1480472 Pharmacology IL-15 mediates immune inflammatory hypernociception by triggering a sequential release of IFN-γ, endothelin, and prostaglandin Waldiceu A. Verri, Jr., Thiago M. Cunha, Carlos A. Parada, Xiao-qing Wei, Sérgio Henrique Ferreira, Foo Y. Liew, and Fernando Q. Cunha PMCID: PMC1480473 Physiology INAUGURAL ARTICLE by a Recently Elected Academy Member: Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction John Geibel, Kumudesh Sritharan, Rainer Geibel, Peter Geibel, J. Scott Persing, Achim Seeger, Torsten K. Roepke, Markus Deichstetter, Christian Prinz, Sam X. Cheng, David Martin, and Steven C. Hebert PMCID: PMC1475505 Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: Implications for atrioventricular conduction in the heart Feliksas F. Bukauskas, Maria M. Kreuzberg, Mindaugas Rackauskas, Angele Bukauskiene, Michael V. L. Bennett, Vytas K. Verselis, and Klaus Willecke PMCID: PMC1480474 Plant Biology A redox-regulated chloroplast protein phosphatase binds to starch diurnally and functions in its accumulation Lubomir N. Sokolov, Jose R. Dominguez-Solis, Anne-Laure Allary, Bob B. Buchanan, and Sheng Luan PMCID: PMC1480475 From the Cover:
AtALMT1, which encodes a malate transporter, is identified as one of several genes critical for aluminum tolerance in Arabidopsis Owen A. Hoekenga, Lyza G. Maron, Miguel A. Piñeros, Geraldo M. A. Cançado, Jon Shaff, Yuriko Kobayashi, Peter R. Ryan, Bei Dong, Emmanuel Delhaize, Takayuki Sasaki, Hideaki Matsumoto, Yoko Yamamoto, Hiroyuki Koyama, and Leon V. Kochian PMCID: PMC1480476 Corrections Correction for Gingrich et al., Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2 PMCID: PMC1480477 Corrects: Jeffrey R. Gingrich, et al. Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2. Proc Natl Acad Sci U S A. 2004 April 20; 101(16): 6237–6242. Correction for Martin et al., Evolution of human–chimpanzee differences in malaria susceptibility: Relationship to human genetic loss of N-glycolylneuraminic acid PMCID: PMC1480478 Corrects: Maria J. Martin, et al. Evolution of human-chimpanzee differences in malaria susceptibility: Relationship to human genetic loss of N-glycolylneuraminic acid. Proc Natl Acad Sci U S A. 2005 September 6; 102(36): 12819–12824. Correction for Watts et al., Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1 PMCID: PMC1480479 Corrects: Ralph N. Watts, et al. Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1. Proc Natl Acad Sci U S A. 2006 May 16; 103(20): 7670–7675. |
