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Volume 103(8);  February 21, 2006
Inaugural Article
Retinoic acid regulates sex-specific timing of meiotic initiation in mice
Jana Koubova, Douglas B. Menke, Qing Zhou, Blanche Capel, Michael D. Griswold, and David C. Page
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2474–2479. Published online 2006 February 6. doi: 10.1073/pnas.0510813103.
PMCID: PMC1413806
This Week in PNAS
In This Issue
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2467–2468. doi: 10.1073/pnas.iti0806103.
PMCID: PMC1413863
Commentary
A globin in every cell?
Austen F. Riggs and Thomas A. Gorr
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2469–2470. Published online 2006 February 15. doi: 10.1073/pnas.0600290103.
PMCID: PMC1413860
Profile
Profile of David C. Page
Bijal Trivedi
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2471–2473. Published online 2006 February 15. doi: 10.1073/pnas.0600615103.
PMCID: PMC1413862
Tissue Engineering Special Feature
Research Articles
In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation
Néha Datta, Quynh P. Pham, Upma Sharma, Vassilios I. Sikavitsas, John A. Jansen, and Antonios G. Mikos
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2488–2493. Published online 2006 February 13. doi: 10.1073/pnas.0505661103.
PMCID: PMC1413766
Regulating activation of transplanted cells controls tissue regeneration
Elliott Hill, Tanyarut Boontheekul, and David J. Mooney
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2494–2499. Published online 2006 February 13. doi: 10.1073/pnas.0506004103.
PMCID: PMC1413770
Relevance and safety of telomerase for human tissue engineering
Rebecca Y. Klinger, Juliana L. Blum, Bevin Hearn, Benjamin Lebow, and Laura E. Niklason
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2500–2505. Published online 2006 February 13. doi: 10.1073/pnas.0508184103.
PMCID: PMC1413782
Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1α variant for local induction of angiogenesis
Diana Trentin, Heike Hall, Sandra Wechsler, and Jeffrey A. Hubbell
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2506–2511. Published online 2006 February 13. doi: 10.1073/pnas.0505964102.
PMCID: PMC1413769
From the Cover:
A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo
Millicent C. Ford, James P. Bertram, Sara Royce Hynes, Michael Michaud, Qi Li, Michael Young, Steven S. Segal, Joseph A. Madri, and Erin B. Lavik
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2512–2517. Published online 2006 February 10. doi: 10.1073/pnas.0506020102.
PMCID: PMC1413771
Perspective
Microscale technologies for tissue engineering and biology
Ali Khademhosseini, Robert Langer, Jeffrey Borenstein, and Joseph P. Vacanti
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2480–2487. Published online 2006 February 13. doi: 10.1073/pnas.0507681102.
PMCID: PMC1413775
Physical Sciences
Chemistry
Principles of self-assembly of helical pores from dendritic dipeptides
Virgil Percec, Andrés E. Dulcey, Mihai Peterca, Monica Ilies, Sami Nummelin, Monika J. Sienkowska, and Paul A. Heiney
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2518–2523. Published online 2006 February 9. doi: 10.1073/pnas.0509676103.
PMCID: PMC1413792
Flexible bilayers with spontaneous curvature lead to lamellar gels and spontaneous vesicles
Bret A. Coldren, Heidi Warriner, Ryan van Zanten, Joseph A. Zasadzinski, and Eric B. Sirota
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2524–2529. Published online 2006 February 8. doi: 10.1073/pnas.0507024103.
PMCID: PMC1413774
From the Cover:
Self-fulfilling cavitands: Packing alkyl chains into small spaces
Byron W. Purse and Julius Rebek, Jr.
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2530–2534. Published online 2006 February 13. doi: 10.1073/pnas.0511149103.
PMCID: PMC1413836
Mathematics
Conformal invariants associated to a measure
Sun-Yung A. Chang, Matthew J. Gursky, and Paul Yang
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2535–2540. Published online 2006 February 10. doi: 10.1073/pnas.0510814103.
PMCID: PMC1413807
Physics
Direct structural observation of a molecular junction by high-energy x-ray reflectometry
Michael Lefenfeld, Julian Baumert, Eli Sloutskin, Ivan Kuzmenko, Peter Pershan, Moshe Deutsch, Colin Nuckolls, and Benjamin M. Ocko
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2541–2545. Published online 2006 February 8. doi: 10.1073/pnas.0508070103.
PMCID: PMC1413780
Biological Sciences
Applied Biological Sciences
In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation
Néha Datta, Quynh P. Pham, Upma Sharma, Vassilios I. Sikavitsas, John A. Jansen, and Antonios G. Mikos
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2488–2493. Published online 2006 February 13. doi: 10.1073/pnas.0505661103.
PMCID: PMC1413766
Regulating activation of transplanted cells controls tissue regeneration
Elliott Hill, Tanyarut Boontheekul, and David J. Mooney
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2494–2499. Published online 2006 February 13. doi: 10.1073/pnas.0506004103.
PMCID: PMC1413770
Relevance and safety of telomerase for human tissue engineering
Rebecca Y. Klinger, Juliana L. Blum, Bevin Hearn, Benjamin Lebow, and Laura E. Niklason
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2500–2505. Published online 2006 February 13. doi: 10.1073/pnas.0508184103.
PMCID: PMC1413782
Biochemistry
The structure of a ring-opened proliferating cell nuclear antigen–replication factor C complex revealed by fluorescence energy transfer
Zhihao Zhuang, Bonita L. Yoder, Peter M. J. Burgers, and Stephen J. Benkovic
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2546–2551. Published online 2006 February 13. doi: 10.1073/pnas.0511263103.
PMCID: PMC1413853
The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function
Ming-Hong Chuang, Ming-Shiang Wu, Wan-Lin Lo, Jaw-Town Lin, Chi-Huey Wong, and Shyh-Horng Chiou
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2552–2557. Published online 2006 February 15. doi: 10.1073/pnas.0510770103.
PMCID: PMC1413804
Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis
Luke J. Alderwick, Virginie Molle, Laurent Kremer, Alain J. Cozzone, Timothy R. Dafforn, Gurdyal S. Besra, and Klaus Fütterer
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2558–2563. Published online 2006 February 13. doi: 10.1073/pnas.0507766103.
PMCID: PMC1413777
Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles
Alexander A. Ishchenko, Eric Deprez, Andrei Maksimenko, Jean-Claude Brochon, Patrick Tauc, and Murat K. Saparbaev
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2564–2569. Published online 2006 February 10. doi: 10.1073/pnas.0508582103.
PMCID: PMC1413785
Crystal structure of obelin after Ca2+-triggered bioluminescence suggests neutral coelenteramide as the primary excited state
Zhi-Jie Liu, Galina A. Stepanyuk, Eugene S. Vysotski, John Lee, Svetlana V. Markova, Natalia P. Malikova, and Bi-Cheng Wang
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2570–2575. Published online 2006 February 8. doi: 10.1073/pnas.0511142103.
PMCID: PMC1413834
Structure and mechanism of the Propionibacterium acnes polyunsaturated fatty acid isomerase
Alena Liavonchanka, Ellen Hornung, Ivo Feussner, and Markus Georg Rudolph
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2576–2581. Published online 2006 February 13. doi: 10.1073/pnas.0510144103.
PMCID: PMC1413795
Agrobacterium tumefaciens VirB8 structure reveals potential protein–protein interaction sites
Susan Bailey, Doyle Ward, Rebecca Middleton, J. Gunter Grossmann, and Patricia C. Zambryski
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2582–2587. Published online 2006 February 15. doi: 10.1073/pnas.0511216103.
PMCID: PMC1413848
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites
Maria G. Kapetanaki, Jennifer Guerrero-Santoro, Dawn C. Bisi, Ching L. Hsieh, Vesna Rapić-Otrin, and Arthur S. Levine
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2588–2593. Published online 2006 February 10. doi: 10.1073/pnas.0511160103.
PMCID: PMC1413840
Cell-type-selective induction of c-jun by TAF4b directs ovarian-specific transcription networks
Kenneth G. Geles, Richard N. Freiman, Wei-Li Liu, Shuang Zheng, Ekaterina Voronina, and Robert Tjian
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2594–2599. Published online 2006 February 10. doi: 10.1073/pnas.0510764103.
PMCID: PMC1413803
Biophysics
Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold
Min Wang, Thomas E. Wales, and Michael C. Fitzgerald
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2600–2604. Published online 2006 February 10. doi: 10.1073/pnas.0508121103.
PMCID: PMC1413781
On the origin and highly likely completeness of single-domain protein structures
Yang Zhang, Isaac A. Hubner, Adrian K. Arakaki, Eugene Shakhnovich, and Jeffrey Skolnick
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2605–2610. Published online 2006 February 14. doi: 10.1073/pnas.0509379103.
PMCID: PMC1413790
Crystal structure of human indoleamine 2,3-dioxygenase: Catalytic mechanism of O2 incorporation by a heme-containing dioxygenase
Hiroshi Sugimoto, Shun-ichiro Oda, Takashi Otsuki, Tomoya Hino, Tadashi Yoshida, and Yoshitsugu Shiro
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2611–2616. Published online 2006 February 13. doi: 10.1073/pnas.0508996103.
PMCID: PMC1413787
Mitochondrial carriers in the cytoplasmic state have a common substrate binding site
Alan J. Robinson and Edmund R. S. Kunji
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2617–2622. Published online 2006 February 9. doi: 10.1073/pnas.0509994103.
PMCID: PMC1413793
DNA conformation on surfaces measured by fluorescence self-interference
Lev Moiseev, M. Selim Ünlü, Anna K. Swan, Bennett B. Goldberg, and Charles R. Cantor
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2623–2628. Published online 2006 February 13. doi: 10.1073/pnas.0511214103.
PMCID: PMC1413847
Multiconformation continuum electrostatics analysis of the NhaA Na+/H+ antiporter of Escherichia coli with functional implications
Elena Olkhova, Carola Hunte, Emanuela Screpanti, Etana Padan, and Hartmut Michel
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2629–2634. Published online 2006 February 13. doi: 10.1073/pnas.0510914103.
PMCID: PMC1413810
Cell Biology
Association of brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) with recycling endosomes during transferrin uptake
Xiaoyan Shen, Kai-Feng Xu, Qingyuan Fan, Gustavo Pacheco-Rodriguez, Joel Moss, and Martha Vaughan
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2635–2640. Published online 2006 February 13. doi: 10.1073/pnas.0510599103.
PMCID: PMC1413799
The HIV lipidome: A raft with an unusual composition
Britta Brügger, Bärbel Glass, Per Haberkant, Iris Leibrecht, Felix T. Wieland, and Hans-Georg Kräusslich
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2641–2646. Published online 2006 February 15. doi: 10.1073/pnas.0511136103.
PMCID: PMC1413831
The chromatoid body of male germ cells: Similarity with processing bodies and presence of Dicer and microRNA pathway components
Noora Kotaja, Suvendra N. Bhattacharyya, Lukasz Jaskiewicz, Sarah Kimmins, Martti Parvinen, Witold Filipowicz, and Paolo Sassone-Corsi
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2647–2652. Published online 2006 February 13. doi: 10.1073/pnas.0509333103.
PMCID: PMC1413789
Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
Tianzheng Yu, James L. Robotham, and Yisang Yoon
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2653–2658. Published online 2006 February 13. doi: 10.1073/pnas.0511154103.
PMCID: PMC1413838
RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells
Janet Kalesnikoff, Eon J. Rios, Ching-Cheng Chen, Susumu Nakae, Brian A. Zabel, Eugene C. Butcher, Mindy Tsai, See-Ying Tam, and Stephen J. Galli
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2659–2664. Published online 2006 February 21. doi: 10.1073/pnas.0511191103.
PMCID: PMC1413845
Synergistic roles of platelet-derived growth factor-BB and interleukin-1β in phenotypic modulation of human aortic smooth muscle cells
Cheng-Nan Chen, Yi-Shuan J. Li, Yi-Ting Yeh, Pei-Ling Lee, Shunichi Usami, Shu Chien, and Jeng-Jiann Chiu
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2665–2670. Published online 2006 February 13. doi: 10.1073/pnas.0510973103.
PMCID: PMC1413813
Regulation of apoptosis by the p8/prothymosin α complex
Cédric Malicet, Valentin Giroux, Sophie Vasseur, Jean Charles Dagorn, José Luis Neira, and Juan L. Iovanna
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2671–2676. Published online 2006 February 14. doi: 10.1073/pnas.0508955103.
PMCID: PMC1413786
Z-DNA-forming sequences generate large-scale deletions in mammalian cells
Guliang Wang, Laura A. Christensen, and Karen M. Vasquez
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2677–2682. Published online 2006 February 10. doi: 10.1073/pnas.0511084103.
PMCID: PMC1413824
Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei
Carmen Citterio, Heather D. Jones, Gustavo Pacheco-Rodriguez, Aminul Islam, Joel Moss, and Martha Vaughan
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2683–2688. Published online 2006 February 8. doi: 10.1073/pnas.0510571103.
PMCID: PMC1413798
IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-κB activation
Yoon-Jae Song, Kai-Yu Jen, Vishal Soni, Elliott Kieff, and Ellen Cahir-McFarland
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2689–2694. Published online 2006 February 13. doi: 10.1073/pnas.0511096103.
PMCID: PMC1413826
Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition
Tulsiram Prathapam, Sarah Tegen, Thordur Oskarsson, Andreas Trumpp, and G. Steven Martin
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2695–2700. Published online 2006 February 13. doi: 10.1073/pnas.0511186103.
PMCID: PMC1413844
Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity
Dorothea Brandhorst, Daniel Zwilling, Silvio O. Rizzoli, Undine Lippert, Thorsten Lang, and Reinhard Jahn
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2701–2706. Published online 2006 February 9. doi: 10.1073/pnas.0511138103.
PMCID: PMC1413832
Developmental Biology
Retinoic acid regulates sex-specific timing of meiotic initiation in mice
Jana Koubova, Douglas B. Menke, Qing Zhou, Blanche Capel, Michael D. Griswold, and David C. Page
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2474–2479. Published online 2006 February 6. doi: 10.1073/pnas.0510813103.
PMCID: PMC1413806
Automated cell lineage tracing in Caenorhabditis elegans
Zhirong Bao, John I. Murray, Thomas Boyle, Siew Loon Ooi, Matthew J. Sandel, and Robert H. Waterston
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2707–2712. Published online 2006 February 13. doi: 10.1073/pnas.0511111103.
PMCID: PMC1413828
SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos
Xungang Tan, Josep Rotllant, Huiqing Li, Patrick DeDeyne, and Shao Jun Du
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2713–2718. Published online 2006 February 13. doi: 10.1073/pnas.0509503103.
PMCID: PMC1531647
In search of rat stem Leydig cells: Identification, isolation, and lineage-specific development
Ren-Shan Ge, Qiang Dong, Chantal M. Sottas, Vassilios Papadopoulos, Barry R. Zirkin, and Matthew P. Hardy
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2719–2724. Published online 2006 February 8. doi: 10.1073/pnas.0507692103.
PMCID: PMC1413776
Testicular germ cells can colonize sexually undifferentiated embryonic gonad and produce functional eggs in fish
Tomoyuki Okutsu, Kensuke Suzuki, Yutaka Takeuchi, Toshio Takeuchi, and Goro Yoshizaki
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2725–2729. Published online 2006 February 10. doi: 10.1073/pnas.0509218103.
PMCID: PMC1413788
Evolution
Buffering of crucial functions by paleologous duplicated genes may contribute cyclicality to angiosperm genome duplication
Brad A. Chapman, John E. Bowers, Frank A. Feltus, and Andrew H. Paterson
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2730–2735. Published online 2006 February 8. doi: 10.1073/pnas.0507782103.
PMCID: PMC1413778
Phanerozoic marine biodiversity dynamics in light of the incompleteness of the fossil record
Peter J. Lu, Motohiro Yogo, and Charles R. Marshall
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2736–2739. Published online 2006 February 13. doi: 10.1073/pnas.0511083103.
PMCID: PMC1413823
Genetics
A large family of ancient repeat elements in the human genome is under strong selection
Michael Kamal, Xiaohui Xie, and Eric S. Lander
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2740–2745. Published online 2006 February 13. doi: 10.1073/pnas.0511238103.
PMCID: PMC1413850
Cell-type-specific signatures of microRNAs on target mRNA expression
Pranidhi Sood, Azra Krek, Mihaela Zavolan, Giuseppe Macino, and Nikolaus Rajewsky
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2746–2751. Published online 2006 February 13. doi: 10.1073/pnas.0511045103.
PMCID: PMC1413820
Immunology
Negative regulation of activation-induced cytidine deaminase in B cells
Taro Muto, Il-mi Okazaki, Shuichi Yamada, Yoshimasa Tanaka, Kazuo Kinoshita, Masamichi Muramatsu, Hitoshi Nagaoka, and Tasuku Honjo
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2752–2757. Published online 2006 February 13. doi: 10.1073/pnas.0510970103.
PMCID: PMC1413812
Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction
Sayuri Yamazaki, Munjal Patel, Alice Harper, Anthony Bonito, Hidehiro Fukuyama, Maggi Pack, Kristin V. Tarbell, Mia Talmor, Jeffrey V. Ravetch, Kayo Inaba, and Ralph M. Steinman
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2758–2763. Published online 2006 February 10. doi: 10.1073/pnas.0510606103.
PMCID: PMC1413800
An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses
Paul G. Thomas, Scott A. Brown, Wen Yue, Jenny So, Richard J. Webby, and Peter C. Doherty
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2764–2769. Published online 2006 February 10. doi: 10.1073/pnas.0511185103.
PMCID: PMC1413843
Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren’s syndrome
Jacques-Eric Gottenberg, Nicolas Cagnard, Carlo Lucchesi, Franck Letourneur, Sylvie Mistou, Thierry Lazure, Sebastien Jacques, Nathalie Ba, Marc Ittah, Christine Lepajolec, Marc Labetoulle, Marc Ardizzone, Jean Sibilia, Catherine Fournier, Gilles Chiocchia, and Xavier Mariette
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2770–2775. Published online 2006 February 13. doi: 10.1073/pnas.0510837103.
PMCID: PMC1413808
Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling
Krista M. Heinonen, Nadia Dubé, Annie Bourdeau, Wayne S. Lapp, and Michel L. Tremblay
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2776–2781. Published online 2006 February 13. doi: 10.1073/pnas.0508563103.
PMCID: PMC1413784
Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells
Everett H. Meyer, Sho Goya, Omid Akbari, Gerald J. Berry, Paul B. Savage, Mitchell Kronenberg, Toshinori Nakayama, Rosemarie H. DeKruyff, and Dale T. Umetsu
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2782–2787. Published online 2006 February 14. doi: 10.1073/pnas.0510282103.
PMCID: PMC1413796
Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor
Deborah J. Stauber, Erik W. Debler, Patricia A. Horton, Kendall A. Smith, and Ian A. Wilson
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2788–2793. Published online 2006 February 13. doi: 10.1073/pnas.0511161103.
PMCID: PMC1413841
Medical Sciences
Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1α variant for local induction of angiogenesis
Diana Trentin, Heike Hall, Sandra Wechsler, and Jeffrey A. Hubbell
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2506–2511. Published online 2006 February 13. doi: 10.1073/pnas.0505964102.
PMCID: PMC1413769
From the Cover:
A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo
Millicent C. Ford, James P. Bertram, Sara Royce Hynes, Michael Michaud, Qi Li, Michael Young, Steven S. Segal, Joseph A. Madri, and Erin B. Lavik
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2512–2517. Published online 2006 February 10. doi: 10.1073/pnas.0506020102.
PMCID: PMC1413771
Gene expression changes associated with progression and response in chronic myeloid leukemia
Jerald P. Radich, Hongyue Dai, Mao Mao, Vivian Oehler, Jan Schelter, Brian Druker, Charles Sawyers, Neil Shah, Wendy Stock, Cheryl L. Willman, Stephen Friend, and Peter S. Linsley
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2794–2799. Published online 2006 February 13. doi: 10.1073/pnas.0510423103.
PMCID: PMC1413797
Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds
Jan Pilch, Darren M. Brown, Masanobu Komatsu, Tero A. H. Järvinen, Meng Yang, David Peters, Robert M. Hoffman, and Erkki Ruoslahti
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2800–2804. Published online 2006 February 13. doi: 10.1073/pnas.0511219103.
PMCID: PMC1413849
Liddle’s syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage
Kristin K. Knight, Diane R. Olson, Ruifeng Zhou, and Peter M. Snyder
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2805–2808. Published online 2006 February 13. doi: 10.1073/pnas.0511184103.
PMCID: PMC1413842
Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury
Béatrice Bailly-Maitre, Constantino Fondevila, Fady Kaldas, Nathalie Droin, Fréderic Luciano, Jean-Ehrland Ricci, Rhonda Croxton, Maryla Krajewska, Juan M. Zapata, Jerzy W. Kupiec-Weglinski, Douglas Farmer, and John C. Reed
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2809–2814. Published online 2006 February 14. doi: 10.1073/pnas.0506854103.
PMCID: PMC1413773
Microbiology
Biogeographical distribution and diversity of microbes in methane hydrate-bearing deep marine sediments on the Pacific Ocean Margin
Fumio Inagaki, Takuro Nunoura, Satoshi Nakagawa, Andreas Teske, Mark Lever, Antje Lauer, Masae Suzuki, Ken Takai, Mark Delwiche, Frederick S. Colwell, Kenneth H. Nealson, Koki Horikoshi, Steven D’Hondt, and Bo B. Jørgensen
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2815–2820. Published online 2006 February 13. doi: 10.1073/pnas.0511033103.
PMCID: PMC1413818
Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins
Miguel Gaspar and Thomas Shenk
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2821–2826. Published online 2006 February 13. doi: 10.1073/pnas.0511148103.
PMCID: PMC1413835
The UL41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins
Brunella Taddeo, Weiran Zhang, and Bernard Roizman
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2827–2832. Published online 2006 February 13. doi: 10.1073/pnas.0510712103.
PMCID: PMC1413801
An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants
Nicole T. Liberati, Jonathan M. Urbach, Sachiko Miyata, Daniel G. Lee, Eliana Drenkard, Gang Wu, Jacinto Villanueva, Tao Wei, and Frederick M. Ausubel
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2833–2838. Published online 2006 February 13. doi: 10.1073/pnas.0511100103.
PMCID: PMC1413827
Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence
Hemantha Kulesekara, Vincent Lee, Anja Brencic, Nicole Liberati, Jonathan Urbach, Sachiko Miyata, Daniel G. Lee, Alice N. Neely, Mamoru Hyodo, Yoshihiro Hayakawa, Frederick M. Ausubel, and Stephen Lory
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2839–2844. Published online 2006 February 13. doi: 10.1073/pnas.0511090103.
PMCID: PMC1413825
Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control
H. Chen, G. J. D. Smith, K. S. Li, J. Wang, X. H. Fan, J. M. Rayner, D. Vijaykrishna, J. X. Zhang, L. J. Zhang, C. T. Guo, C. L. Cheung, K. M. Xu, L. Duan, K. Huang, K. Qin, Y. H. C. Leung, W. L. Wu, H. R. Lu, Y. Chen, N. S. Xia, T. S. P. Naipospos, K. Y. Yuen, S. S. Hassan, S. Bahri, T. D. Nguyen, R. G. Webster, J. S. M. Peiris, and Y. Guan
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2845–2850. Published online 2006 February 10. doi: 10.1073/pnas.0511120103.
PMCID: PMC1413830
Type III effector AvrPtoB requires intrinsic E3 ubiquitin ligase activity to suppress plant cell death and immunity
Robert B. Abramovitch, Radmila Janjusevic, C. Erec Stebbins, and Gregory B. Martin
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2851–2856. Published online 2006 February 13. doi: 10.1073/pnas.0507892103.
PMCID: PMC1413779
A pneumococcal pilus influences virulence and host inflammatory responses
M. A. Barocchi, J. Ries, X. Zogaj, C. Hemsley, B. Albiger, A. Kanth, S. Dahlberg, J. Fernebro, M. Moschioni, V. Masignani, K. Hultenby, A. R. Taddei, K. Beiter, F. Wartha, A. von Euler, A. Covacci, D. W. Holden, S. Normark, R. Rappuoli, and B. Henriques-Normark
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2857–2862. Published online 2006 February 15. doi: 10.1073/pnas.0511017103.
PMCID: PMC1368962
An enzymatic ruler modulates Lewis antigen glycosylation of Helicobacter pylori LPS during persistent infection
Christina Nilsson, Anna Skoglund, Anthony P. Moran, Heidi Annuk, Lars Engstrand, and Staffan Normark
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2863–2868. Published online 2006 February 13. doi: 10.1073/pnas.0511119103.
PMCID: PMC1413829
Variable host–pathogen compatibility in Mycobacterium tuberculosis
Sebastien Gagneux, Kathryn DeRiemer, Tran Van, Midori Kato-Maeda, Bouke C. de Jong, Sujatha Narayanan, Mark Nicol, Stefan Niemann, Kristin Kremer, M. Cristina Gutierrez, Markus Hilty, Philip C. Hopewell, and Peter M. Small
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2869–2873. Published online 2006 February 13. doi: 10.1073/pnas.0511240103.
PMCID: PMC1413851
Neuroscience
Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype
Cecile Martinat, Jean-Jacques Bacci, Thomas Leete, Jongpil Kim, William B. Vanti, Amy H. Newman, Joo H. Cha, Ulrik Gether, Honggang Wang, and Asa Abeliovich
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2874–2879. Published online 2006 February 13. doi: 10.1073/pnas.0511153103.
PMCID: PMC1413837
Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway
Jianyuan Sun, Peter Bronk, Xinran Liu, Weiping Han, and Thomas C. Südhof
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2880–2885. Published online 2006 February 15. doi: 10.1073/pnas.0511300103.
PMCID: PMC1413856
A voltage-driven switch for ion-independent signaling by ether-à-go-go K+ channels
Andrew P. Hegle, Daniel D. Marble, and Gisela F. Wilson
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2886–2891. Published online 2006 February 13. doi: 10.1073/pnas.0505909103.
PMCID: PMC1413768
From the Cover:
NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation
Giuseppina Amadoro, Maria Teresa Ciotti, Marco Costanzi, Vincenzo Cestari, Pietro Calissano, and Nadia Canu
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2892–2897. Published online 2006 February 13. doi: 10.1073/pnas.0511065103.
PMCID: PMC1413822
Frequency selectivity of synaptic exocytosis in frog saccular hair cells
Mark A. Rutherford and William M. Roberts
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2898–2903. Published online 2006 February 10. doi: 10.1073/pnas.0511005103.
PMCID: PMC1413814
Ceramide mediates the rapid phase of febrile response to IL-1β
Manuel Sanchez-Alavez, Iustin V. Tabarean, M. Margarita Behrens, and Tamas Bartfai
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2904–2908. Published online 2006 February 13. doi: 10.1073/pnas.0510960103.
PMCID: PMC1413811
Partial tuning of motor cortex neurons to final posture in a free-moving paradigm
Tyson N. Aflalo and Michael S. A. Graziano
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2909–2914. Published online 2006 February 10. doi: 10.1073/pnas.0511139103.
PMCID: PMC1413833
Role for calcium/calmodulin-dependent protein kinase II in the p75-mediated regulation of sympathetic cholinergic transmission
John D. Slonimsky, Mark D. Mattaliano, Jung-il Moon, Leslie C. Griffith, and Susan J. Birren
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2915–2919. Published online 2006 February 13. doi: 10.1073/pnas.0511276103.
PMCID: PMC1413855
Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells
Maria Carmen Inda, Javier DeFelipe, and Alberto Muñoz
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2920–2925. Published online 2006 February 10. doi: 10.1073/pnas.0511197103.
PMCID: PMC1413846
CSPα-deficiency causes massive and rapid photoreceptor degeneration
Frank Schmitz, Lucia Tabares, Darina Khimich, Nicola Strenzke, Pedro de la Villa-Polo, Manuel Castellano-Muñoz, Anna Bulankina, Tobias Moser, Rafael Fernández-Chacón, and Thomas C. Südhof
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2926–2931. Published online 2006 February 13. doi: 10.1073/pnas.0510060103.
PMCID: PMC1413794
Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference
Emmanuel Valjent, Anne-Gaëlle Corbillé, Jesus Bertran-Gonzalez, Denis Hervé, and Jean-Antoine Girault
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2932–2937. Published online 2006 February 10. doi: 10.1073/pnas.0511030103.
PMCID: PMC1413817
κ opioids selectively control dopaminergic neurons projecting to the prefrontal cortex
Elyssa B. Margolis, Hagar Lock, Vladimir I. Chefer, Toni S. Shippenberg, Gregory O. Hjelmstad, and Howard L. Fields
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2938–2942. Published online 2006 February 13. doi: 10.1073/pnas.0511159103.
PMCID: PMC1413839
Effects of cyclothiazide on GluR1/AMPA receptors
Sergio Fucile, Ricardo Miledi, and Fabrizio Eusebi
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2943–2947. Published online 2006 February 10. doi: 10.1073/pnas.0511063103.
PMCID: PMC1413821
Posterior α activity is not phase-reset by visual stimuli
Ali Mazaheri and Ole Jensen
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2948–2952. Published online 2006 February 10. doi: 10.1073/pnas.0505785103.
PMCID: PMC1413767
Pharmacology
MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics
Christopher N. Davis, Enrique Mann, M. Margarita Behrens, Svetlana Gaidarova, Mitra Rebek, Julius Rebek, Jr., and Tamas Bartfai
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2953–2958. Published online 2006 February 13. doi: 10.1073/pnas.0510802103.
PMCID: PMC1413805
Physiology
Role of estrogen receptor β in colonic epithelium
Osamu Wada-Hiraike, Otabek Imamov, Haruko Hiraike, Kjell Hultenby, Thomas Schwend, Yoko Omoto, Margaret Warner, and Jan-Åke Gustafsson
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2959–2964. Published online 2006 February 13. doi: 10.1073/pnas.0511271103.
PMCID: PMC1413854
Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation
Emanuela M. Bruscia, Joanna E. Price, Ee-Chun Cheng, Scott Weiner, Christina Caputo, Elisa C. Ferreira, Marie E. Egan, and Diane S. Krause
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2965–2970. Published online 2006 February 15. doi: 10.1073/pnas.0510758103.
PMCID: PMC1413802
Directly observed reversible shape changes and hemoglobin stratification during centrifugation of human and Amphiuma red blood cells
Joseph F. Hoffman and Shinya Inoué
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2971–2976. Published online 2006 February 13. doi: 10.1073/pnas.0510884103.
PMCID: PMC1413809
From The Cover:
Hypoxia-inducible myoglobin expression in nonmuscle tissues
Jane Fraser, Luciane Vieira de Mello, Deborah Ward, Huw H. Rees, Daryl R. Williams, Yongchang Fang, Andrew Brass, Andrew Y. Gracey, and Andrew R. Cossins
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2977–2981. Published online 2006 February 9. doi: 10.1073/pnas.0508270103.
PMCID: PMC1413783
Depletion “skraps” and dynamic buffering inside the cellular calcium store
Bradley S. Launikonis, Jingsong Zhou, Leandro Royer, Thomas R. Shannon, Gustavo Brum, and Eduardo Ríos
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2982–2987. Published online 2006 February 10. doi: 10.1073/pnas.0511252103.
PMCID: PMC1413852
Plant Biology
A complete ferredoxin/thioredoxin system regulates fundamental processes in amyloplasts
Yves Balmer, William H. Vensel, Nick Cai, Wanda Manieri, Peter Schürmann, William J. Hurkman, and Bob B. Buchanan
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2988–2993. Published online 2006 February 15. doi: 10.1073/pnas.0511040103.
PMCID: PMC1413819
Vacuolar invertase regulates elongation of Arabidopsis thaliana roots as revealed by QTL and mutant analysis
Lidiya I. Sergeeva, Joost J. B. Keurentjes, Leónie Bentsink, Jenneke Vonk, Linus H. W. van der Plas, Maarten Koornneef, and Dick Vreugdenhil
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2994–2999. Published online 2006 February 15. doi: 10.1073/pnas.0511015103.
PMCID: PMC1413815
Psychology
Maternal mediation, stress inoculation, and the development of neuroendocrine stress resistance in primates
Karen J. Parker, Christine L. Buckmaster, Karan Sundlass, Alan F. Schatzberg, and David M. Lyons
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 3000–3005. Published online 2006 February 10. doi: 10.1073/pnas.0506571103.
PMCID: PMC1413772
Corrections
Correction for Hal Alper et al., Tuning genetic control through promoter engineering
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 3006. Published online 2006 February 2. doi: 10.1073/pnas.0511314103.
PMCID: PMC1413857
Corrects: Hal Alper, et al. Tuning genetic control through promoter engineering. Proc Natl Acad Sci U S A. 2005 September 6; 102(36): 12678–12683.
Correction for Joseph DeMasi et al., Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 3007. Published online 2006 February 8. doi: 10.1073/pnas.0600157103.
PMCID: PMC1413858
Corrects: Joseph DeMasi, et al. Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding. Proc Natl Acad Sci U S A. 2005 August 9; 102(32): 11486–11491.
Correction for Satoshi Nagata et al., Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 3007. Published online 2006 February 8. doi: 10.1073/pnas.0600274103.
PMCID: PMC1413859
Corrects: Satoshi Nagata, et al. Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy. Proc Natl Acad Sci U S A. 2005 May 31; 102(22): 7946–7951.
Correction for M. Bar et al., Top-down facilitation of visual recognition
M. Bar, K.S. Kassam, A.S. Ghuman, J. Boshyan, A.M. Schmid, A.M. Dale, M.S. Hämäläinen, K. Marinkovic, D.L. Schacter, B.R. Rosen, and E. Halgren
Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 3007. Published online 2006 February 8. doi: 10.1073/pnas.0600325103.
PMCID: PMC1413861
Corrects: M. Bar, et al. Top-down facilitation of visual recognition. Proc Natl Acad Sci U S A. 2006 January 10; 103(2): 449–454.
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