| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 February 14; 103(7): 2003–2004. doi: 10.1073/iti0706103.PMCID: PMC1413765 Commentaries Making a virtue out of a necessity: Hurricanes and the resilience of community organization Robert D. Holt PMCID: PMC1413764 Standing guard: Perinuclear localization of an RNA-dependent RNA polymerase William G. Kelly PMCID: PMC1413763 Profiles Profile of Don Helmberger Nick Zagorski PMCID: PMC1413711 Profile of Isaac M. Held Bijal Trivedi PMCID: PMC1413754 Physical Sciences Applied Physical Sciences The role of the airline transportation network in the prediction and predictability of global epidemics Vittoria Colizza, Alain Barrat, Marc Barthélemy, and Alessandro Vespignani PMCID: PMC1413717 Chemistry Engineering a biospecific communication pathway between cells and electrodes Joel H. Collier and Milan Mrksich PMCID: PMC1413682 Controlling the shape, orientation, and linkage of carbon nanotube features with nano affinity templates Yuhuang Wang, Daniel Maspoch, Shengli Zou, George C. Schatz, Richard E. Smalley, and Chad A. Mirkin PMCID: PMC1413750 Mathematics The Kadison–Singer Problem in mathematics and engineering Peter G. Casazza and Janet Crandell Tremain PMCID: PMC1413700 Physics Lateral mobility of proteins in liquid membranes revisited Y. Gambin, R. Lopez-Esparza, M. Reffay, E. Sierecki, N. S. Gov, M. Genest, R. S. Hodges, and W. Urbach PMCID: PMC1413751 Biological Sciences Applied Biological Sciences 13C isotopologue perturbation studies of Listeria monocytogenes carbon metabolism and its modulation by the virulence regulator PrfA Wolfgang Eisenreich, Jörg Slaghuis, Ralf Laupitz, Johanna Bussemer, Jochen Stritzker, Christine Schwarz, Roland Schwarz, Thomas Dandekar, Werner Goebel, and Adelbert Bacher PMCID: PMC1413697 Biochemistry Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis Li-Mei Yan, Marianna Tatarek-Nossol, Aleksandra Velkova, Athanasios Kazantzis, and Aphrodite Kapurniotu PMCID: PMC1413694 Fast complementation of split fluorescent protein triggered by DNA hybridization Vadim V. Demidov, Nikolay V. Dokholyan, Carlos Witte-Hoffmann, Poornima Chalasani, Hung-Wei Yiu, Feng Ding, Yong Yu, Charles R. Cantor, and Natalia E. Broude PMCID: PMC1413755 Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes Guoping Da, Jeffrey Lenkart, Kehao Zhao, Ramin Shiekhattar, Bradley R. Cairns, and Ronen Marmorstein PMCID: PMC1413740 Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target Maria C. Bewley, Vito Graziano, Jiangsheng Jiang, Eileen Matz, F. William Studier, Anthony E. Pegg, Catherine S. Coleman, and John M. Flanagan PMCID: PMC1360125 A genetic locus required for iron acquisition in Mycobacterium tuberculosis R. Krithika, Uttara Marathe, Priti Saxena, Mohd. Zeeshan Ansari, Debasisa Mohanty, and Rajesh S. Gokhale PMCID: PMC1413701 Arsenic detoxification and evolution of trimethylarsine gas by a microbial arsenite S-adenosylmethionine methyltransferase Jie Qin, Barry P. Rosen, Yang Zhang, Gejiao Wang, Sylvia Franke, and Christopher Rensing PMCID: PMC1413689 Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding Esther Eytan, Yakir Moshe, Ilana Braunstein, and Avram Hershko PMCID: PMC1413726 An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARγ, adipogenesis, and insulin-responsive hexose transport Xiaoqing Tang, Adilson Guilherme, Abhijit Chakladar, Aimee M. Powelka, Silvana Konda, Joseph V. Virbasius, Sarah M. C. Nicoloro, Juerg Straubhaar, and Michael P. Czech PMCID: PMC1413698 Biophysics Monitoring bacterial chemotaxis by using bioluminescence resonance energy transfer: Absence of feedback from the flagellar motors Thomas S. Shimizu, Nicolas Delalez, Klemens Pichler, and Howard C. Berg PMCID: PMC1413742 Lateral mobility of proteins in liquid membranes revisited Y. Gambin, R. Lopez-Esparza, M. Reffay, E. Sierecki, N. S. Gov, M. Genest, R. S. Hodges, and W. Urbach PMCID: PMC1413751 Dictyostelium myosin II mechanochemistry promotes active behavior of the cortex on long time scales Kristine D. Girard, Scot C. Kuo, and Douglas N. Robinson PMCID: PMC1413706 Solution structure of p53 core domain: Structural basis for its instability José Manuel Pérez Cañadillas, Henning Tidow, Stefan M. V. Freund, Trevor J. Rutherford, Hwee Ching Ang, and Alan R. Fersht PMCID: PMC1413739 Core domain interactions in full-length p53 in solution Dmitry B. Veprintsev, Stefan M. V. Freund, Antonina Andreeva, Stacey E. Rutledge, Henning Tidow, José Manuel Pérez Cañadillas, Caroline M. Blair, and Alan R. Fersht PMCID: PMC1413758 Nanomechanics of the subtectorial space caused by electromechanics of cochlear outer hair cells Manuela Nowotny and Anthony W. Gummer PMCID: PMC1413757 Crystal structure of human apolipoprotein A-I: Insights into its protective effect against cardiovascular diseases A. Abdul Ajees, G. M. Anantharamaiah, Vinod K. Mishra, M. Mahmood Hussain, and H. M. Krishna Murthy PMCID: PMC1413691 Roles of static and dynamic domains in stability and catalysis of adenylate kinase Euiyoung Bae and George N. Phillips, Jr. PMCID: PMC1413696 FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells Bruno H. Meyer, Jean-Manuel Segura, Karen L. Martinez, Ruud Hovius, Nathalie George, Kai Johnsson, and Horst Vogel PMCID: PMC1413699 Directing electron transfer within Photosystem I by breaking H-bonds in the cofactor branches Yajing Li, Art van der Est, Marie Gabrielle Lucas, V. M. Ramesh, Feifei Gu, Alexander Petrenko, Su Lin, Andrew N. Webber, Fabrice Rappaport, and Kevin Redding PMCID: PMC1413687 Monitoring the direct and indirect damage of DNA bases and polynucleotides by using time-resolved infrared spectroscopy Marina K. Kuimova, Alexander J. Cowan, Pavel Matousek, Anthony W. Parker, Xue Zhong Sun, Michael Towrie, and Michael W. George PMCID: PMC1413690 Cell Biology Hutchinson–Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody Dayle McClintock, Leslie B. Gordon, and Karima Djabali PMCID: PMC1413759 Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling Per Uhlén, Peter M. Burch, Christina Ivins Zito, Manuel Estrada, Barbara E. Ehrlich, and Anton M. Bennett PMCID: PMC1413735 Unraveling the complexity of flux regulation: A new method demonstrated for nutrient starvation in Saccharomyces cerevisiae Sergio Rossell, Coen C. van der Weijden, Alexander Lindenbergh, Arjen van Tuijl, Christof Francke, Barbara M. Bakker, and Hans V. Westerhoff PMCID: PMC1413710 Simple fold composition and modular architecture of the nuclear pore complex Damien Devos, Svetlana Dokudovskaya, Rosemary Williams, Frank Alber, Narayanan Eswar, Brian T. Chait, Michael P. Rout, and Andrej Sali PMCID: PMC1413685 Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells Nuri Ozturk, Esra Erdal, Mine Mumcuoglu, Kamil C. Akcali, Ozden Yalcin, Serif Senturk, Ayca Arslan-Ergul, Bala Gur, Isik Yulug, Rengul Cetin-Atalay, Cengiz Yakicier, Tamer Yagci, Mesut Tez, and Mehmet Ozturk PMCID: PMC1413736 Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal Cheng Cheng Zhang, Andrew D. Steele, Susan Lindquist, and Harvey F. Lodish PMCID: PMC1413720 Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation Craig J. Burd, Christin E. Petre, Lisa M. Morey, Ying Wang, Monica P. Revelo, Christopher A. Haiman, Shan Lu, Cecilia M. Fenoglio-Preiser, Jiwen Li, Erik S. Knudsen, Jiemin Wong, and Karen E. Knudsen PMCID: PMC1413684 Developmental Biology Paracrine signaling through the epithelial estrogen receptor α is required for proliferation and morphogenesis in the mammary gland Sonia Mallepell, Andrée Krust, Pierre Chambon, and Cathrin Brisken PMCID: PMC1413744 Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche Norio Suzuki, Osamu Ohneda, Naoko Minegishi, Mitsuo Nishikawa, Takayuki Ohta, Satoru Takahashi, James Douglas Engel, and Masayuki Yamamoto PMCID: PMC1413708 Dicer function is essential for lung epithelium morphogenesis Kelley S. Harris, Zhen Zhang, Michael T. McManus, Brian D. Harfe, and Xin Sun PMCID: PMC1413733 An essential role for the hematopoietic transcription factor Ikaros in hypothalamic–pituitary-mediated somatic growth Shereen Ezzat, Rene Mader, Sandra Fischer, ShunJiang Yu, Cameron Ackerley, and Sylvia L. Asa PMCID: PMC1413703 Ecology From the Cover:
Nonsynchronous recovery of community characteristics in island spiders after a catastrophic hurricane Thomas W. Schoener and David A. Spiller PMCID: PMC1413712 Evolution Evolution of enzymes in a series is driven by dissimilar functional demands Armindo Salvador and Michael A. Savageau PMCID: PMC1413729 Role of positive selection in the retention of duplicate genes in mammalian genomes Shin-Han Shiu, Jake K. Byrnes, Runsun Pan, Peng Zhang, and Wen-Hsiung Li PMCID: PMC1413713 Comparative genomics provides evidence for close evolutionary relationships between the urotensin II and somatostatin gene families Hervé Tostivint, Lucille Joly, Isabelle Lihrmann, Caroline Parmentier, Alexis Lebon, Mireille Morisson, André Calas, Marc Ekker, and Hubert Vaudry PMCID: PMC1413727 Genetics From the Cover:
SAD-2 is required for meiotic silencing by unpaired DNA and perinuclear localization of SAD-1 RNA-directed RNA polymerase Patrick K. T. Shiu, Denise Zickler, Namboori B. Raju, Gwenael Ruprich-Robert, and Robert L. Metzenberg PMCID: PMC1413707 Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres David Feldser, Margaret A. Strong, and Carol W. Greider PMCID: PMC1413760 A transgenic approach for RNA interference-based genetic screening in mice Shaohua Peng, J. Philippe York, and Pumin Zhang PMCID: PMC1413752 A microRNA expression signature of human solid tumors defines cancer gene targets Stefano Volinia, George A. Calin, Chang-Gong Liu, Stefan Ambs, Amelia Cimmino, Fabio Petrocca, Rosa Visone, Marilena Iorio, Claudia Roldo, Manuela Ferracin, Robyn L. Prueitt, Nozumu Yanaihara, Giovanni Lanza, Aldo Scarpa, Andrea Vecchione, Massimo Negrini, Curtis C. Harris, and Carlo M. Croce PMCID: PMC1413718 Immunology Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: Correlation with increased IL-7 Angela Malaspina, Susan Moir, Jason Ho, Wei Wang, Melissa L. Howell, Marie A. O’Shea, Gregg A. Roby, Catherine A. Rehm, JoAnn M. Mican, Tae-Wook Chun, and Anthony S. Fauci PMCID: PMC1413756 A pilot clinical trial of a recombinant ricin vaccine in normal humans Ellen S. Vitetta, Joan E. Smallshaw, Elaine Coleman, Hasan Jafri, Callie Foster, Robert Munford, and John Schindler PMCID: PMC1413738 Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses Hongbo Chi, Sean P. Barry, Rachel J. Roth, J. Julie Wu, Elizabeth A. Jones, Anton M. Bennett, and Richard A. Flavell PMCID: PMC1413743 Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis Patrice H. Lalive, Til Menge, Cecile Delarasse, Bruno Della Gaspera, Danielle Pham-Dinh, Pablo Villoslada, H.-C. von Büdingen, and Claude P. Genain PMCID: PMC1413723 Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function Yukiko I. Nigo, Masakatsu Yamashita, Kiyoshi Hirahara, Ryo Shinnakasu, Masamichi Inami, Motoko Kimura, Akihiro Hasegawa, Yoichi Kohno, and Toshinori Nakayama PMCID: PMC1413725 The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-β production Tina Mahieu, Jin Mo Park, Hilde Revets, Bastian Pasche, Andreas Lengeling, Jan Staelens, Andy Wullaert, Ineke Vanlaere, Tino Hochepied, Frans van Roy, Michael Karin, and Claude Libert PMCID: PMC1413734 Medical Sciences ALADINI482S causes selective failure of nuclear protein import and hypersensitivity to oxidative stress in triple A syndrome Makito Hirano, Yoshiko Furiya, Hirohide Asai, Akira Yasui, and Satoshi Ueno PMCID: PMC1413683 Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction Bilal B. Ayach, Makoto Yoshimitsu, Fayez Dawood, Mei Sun, Sara Arab, Manyin Chen, Koji Higuchi, Christopher Siatskas, Paul Lee, Hilda Lim, Jane Zhang, Eva Cukerman, William L. Stanford, Jeffrey A. Medin, and Peter P. Liu PMCID: PMC1413746 From the Cover:
Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells MinKyung Yi, Rodrigo A. Villanueva, David L. Thomas, Takaji Wakita, and Stanley M. Lemon PMCID: PMC1413728 Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752 Gromoslaw A. Smolen, Raffaella Sordella, Beth Muir, Gayatry Mohapatra, Anne Barmettler, Heidi Archibald, Woo J. Kim, Ross A. Okimoto, Daphne W. Bell, Dennis C. Sgroi, James G. Christensen, Jeffrey Settleman, and Daniel A. Haber PMCID: PMC1413705 Links between α-catenin, NF-κB, and squamous cell carcinoma in skin Agnieszka Kobielak and Elaine Fuchs PMCID: PMC1413714 Drusen complement components C3a and C5a promote choroidal neovascularization Miho Nozaki, Brian J. Raisler, Eiji Sakurai, J. Vidya Sarma, Scott R. Barnum, John D. Lambris, Yali Chen, Kang Zhang, Balamurali K. Ambati, Judit Z. Baffi, and Jayakrishna Ambati PMCID: PMC1413680 The unique cytoarchitecture of human pancreatic islets has implications for islet cell function Over Cabrera, Dora M. Berman, Norma S. Kenyon, Camillo Ricordi, Per-Olof Berggren, and Alejandro Caicedo PMCID: PMC1413730 In vivo repopulation ability of genetically corrected bone marrow cells from Fanconi anemia patients Odile Cohen-Haguenauer, Bruno Péault, Cécile Bauche, Marie-Thérèse Daniel, Ibrahim Casal, Vincent Levy, Jean Dausset, Michel Boiron, Christian Auclair, Eliane Gluckman, and Michel Marty PMCID: PMC1413721 Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation Amin Majdalawieh, Lei Zhang, Ilia V. Fuki, Daniel J. Rader, and Hyo-Sung Ro PMCID: PMC1413702 Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma Timothy C. Greiner, Chiranjib Dasgupta, Vincent V. Ho, Dennis D. Weisenburger, Lynette M. Smith, James C. Lynch, Julie M. Vose, Kai Fu, James O. Armitage, Rita M. Braziel, Elias Campo, Jan Delabie, Randy D. Gascoyne, Elaine S. Jaffe, Hans K. Muller-Hermelink, German Ott, Andreas Rosenwald, Louis M. Staudt, Michael Y. Im, Mazen W. Karaman, Brian L. Pike, Wing C. Chan, and Joseph G. Hacia PMCID: PMC1413716 Microbiology The glycophorin C N-linked glycan is a critical component of the ligand for the Plasmodium falciparum erythrocyte receptor BAEBL D. C. Ghislaine Mayer, Lubin Jiang, Rajeshwara N. Achur, Ikuko Kakizaki, D. Channe Gowda, and Louis H. Miller PMCID: PMC1413722 From the Cover:
Cohn’s Crenothrix is a filamentous methane oxidizer with an unusual methane monooxygenase Kilian Stoecker, Bernd Bendinger, Björn Schöning, Per H. Nielsen, Jeppe L. Nielsen, Christian Baranyi, Elena R. Toenshoff, Holger Daims, and Michael Wagner PMCID: PMC1413686 Functional dissection of YabA, a negative regulator of DNA replication initiation in Bacillus subtilis Marie-Françoise Noirot-Gros, M. Velten, M. Yoshimura, S. McGovern, T. Morimoto, S. D. Ehrlich, N. Ogasawara, P. Polard, and Philippe Noirot PMCID: PMC1413692 Guanosine 3′,5′-bispyrophosphate coordinates global gene expression during glucose-lactose diauxie in Escherichia coli Matthew F. Traxler, Dong-Eun Chang, and Tyrrell Conway PMCID: PMC1413745 Streptococcal modulation of cellular invasion via TGF-β1 signaling Beinan Wang, Shaoying Li, Peter J. Southern, and Patrick P. Cleary PMCID: PMC1413688 Quorum sensing and multidrug transporters in Escherichia coli Shirley Yang, Christopher R. Lopez, and E. Lynn Zechiedrich PMCID: PMC1413681 Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus Yingfang Liu, Adhar C. Manna, Cheol-Ho Pan, Irina A. Kriksunov, Daniel J. Thiel, Ambrose L. Cheung, and Gongyi Zhang PMCID: PMC1413715 From the Cover:
In situ analysis of nitrogen fixation and metabolic switching in unicellular thermophilic cyanobacteria inhabiting hot spring microbial mats Anne-Soisig Steunou, Devaki Bhaya, Mary M. Bateson, Melanie C. Melendrez, David M. Ward, Eric Brecht, John W. Peters, Michael Kühl, and Arthur R. Grossman PMCID: PMC1413695 Neuroscience S-nitrosothiol depletion in amyotrophic lateral sclerosis Christopher M. Schonhoff, Masaaki Matsuoka, Hemachand Tummala, Michael A. Johnson, Alvaro G. Estevéz, Rui Wu, Andrés Kamaid, Karina C. Ricart, Yuichi Hashimoto, Benjamin Gaston, Timothy L. Macdonald, Zuoshang Xu, and Joan B. Mannick PMCID: PMC1413693 Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals Lance J. Kriegsfeld, Dan Feng Mei, George E. Bentley, Takayoshi Ubuka, Alex O. Mason, Kazuhiko Inoue, Kazuyoshi Ukena, Kazuyoshi Tsutsui, and Rae Silver PMCID: PMC1413747 Unique, common, and interacting cortical correlates of thirst and pain Michael J. Farrell, Gary F. Egan, Frank Zamarripa, Robert Shade, John Blair-West, Peter Fox, and Derek A. Denton PMCID: PMC1413749 Reciprocal actions of REST and a microRNA promote neuronal identity Cecilia Conaco, Stefanie Otto, Jong-Jin Han, and Gail Mandel PMCID: PMC1413753 Pharmacology N-arachidonoyl l-serine, an endocannabinoid-like brain constituent with vasodilatory properties Garry Milman, Yehoshua Maor, Saleh Abu-Lafi, Michal Horowitz, Ruth Gallily, Sandor Batkai, Fong-Ming Mo, Laszlo Offertaler, Pal Pacher, George Kunos, and Raphael Mechoulam PMCID: PMC1413724 Physiology Peroxisome proliferator-activated receptor δ promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage Chih-Hao Lee, Kihwa Kang, Isaac R. Mehl, Russell Nofsinger, William A. Alaynick, Ling-Wa Chong, John M. Rosenfeld, and Ronald M. Evans PMCID: PMC1413732 Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation A. S. Khromov, H. Wang, N. Choudhury, M. McDuffie, B. P. Herring, R. Nakamoto, G. K. Owens, A. P. Somlyo, and A. V. Somlyo PMCID: PMC1413704 Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation Anthony O. Gramolini, Maria G. Trivieri, Gavin Y. Oudit, Thomas Kislinger, Wenping Li, Mikin M. Patel, Andrew Emili, Evangelia G. Kranias, Peter H. Backx, and David H. MacLennan PMCID: PMC1413737 Social Sciences Environmental Sciences Malaria risk on the Amazon frontier Marcia Caldas de Castro, Roberto L. Monte-Mór, Diana O. Sawyer, and Burton H. Singer PMCID: PMC1413719 Psychology The brain differentiates human and non-human grammars: Functional localization and structural connectivity Angela D. Friederici, Jörg Bahlmann, Stefan Heim, Ricarda I. Schubotz, and Alfred Anwander PMCID: PMC1413709 Corrections Correction for Cimmino et al., miR-15 and miR-16 induce apoptosis by targeting BCL2 PMCID: PMC1413731 Corrects: Amelia Cimmino, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A. 2005 September 27; 102(39): 13944–13949. Correction for Sacher et al., The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation PMCID: PMC1413741 Corrects: Michael Sacher, et al. The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation. Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18326–18331. Correction for Gobbi et al., Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis PMCID: PMC1413761 Corrects: G. Gobbi, et al. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proc Natl Acad Sci U S A. 2005 December 20; 102(51): 18620–18625. Correction for Lu et al., EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin PMCID: PMC1413762 Corrects: Quan Lu, et al. EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin. Proc Natl Acad Sci U S A. 2004 December 7; 101(49): 17246–17251. |
