Looked at intensive management of blood glucose levels and long term risk-factors for diabetes complications in type 2 diabetes
UKPDS. BMJ. 2000; 321:405-412.
Note:
The United Kingdom Prospective Diabetes Study (UKPDS) was a 20 year clinical trial co-coordinated by the Diabetes Research Laboratories at Oxford.
The UKPDS was designed to determine whether intensive management of type 2 diabetes in controlling blood glucose levels resulted in a reduction in long term diabetes complications compared with standard care.
Reference
Stratton IM, Et al. Association of glycemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study. BMJ. 2000; 321:405-412.