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Sponsors and Collaborators: |
Affective Neuroscience Laboratory Massachusetts General Hospital |
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Information provided by: | Affective Neuroscience Laboratory |
ClinicalTrials.gov Identifier: | NCT00205933 |
The purpose of this project is to use behavioral techniques to investigate emotional processing in subjects with major depression and healthy comparison subjects.
Condition |
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Major Depressive Disorder Bipolar Disorder |
Study Type: | Observational |
Study Design: | Cohort, Cross-Sectional |
Official Title: | Behavioral Processes Underlying Reward Processing in Depression |
Enrollment: | 78 |
Study Start Date: | April 2004 |
Study Completion Date: | June 2007 |
A promising strategy for parsing the heterogeneity of Major Depressive Disorder is to identify phenotypes characterized by reliable functional abnormalities. Anhedonia, the lack of reactivity to pleasurable stimuli, is considered a trait marker for depression. Using an objective behavioral task this project aims to investigate hedonic capacity in subjects meeting a DSM-IV diagnosis of Major Depressive Disorder.
Ages Eligible for Study: | 18 Years to 64 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Control participants, Participants with MDD, Participants with Bipolar Disorder
Inclusion Criteria:
Depressed participants:
Bipolar participants:
Control Participants:
Exclusion Criteria:
United States, Massachusetts | |
The Depression Clinical and Research Program, Massachusetts General Hospital | |
Boston, Massachusetts, United States, 02114 | |
Affective Neuroscience Laboratory, Department of Psychology, Harvard University | |
Cambridge, Massachusetts, United States, 02138 |
Principal Investigator: | Diego A Pizzagalli, PhD | Harvard University |
Responsible Party: | Harvard University ( Diego Pizzagalli, Principal Investigator ) |
Study ID Numbers: | 2003-P-000994 |
Study First Received: | September 13, 2005 |
Last Updated: | December 4, 2007 |
ClinicalTrials.gov Identifier: | NCT00205933 |
Health Authority: | United States: Federal Government |
Depression Bipolar Disorder Reward Processing |
Affective Disorders, Psychotic Depression Mental Disorders Bipolar Disorder Mood Disorders |
Psychotic Disorders Depressive Disorder, Major Depressive Disorder Behavioral Symptoms |
Pathologic Processes Disease |