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Sponsors and Collaborators: |
Piyavate Hospital T.C Union Global Plc. |
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Information provided by: | Piyavate Hospital |
ClinicalTrials.gov Identifier: | NCT00127309 |
Glutathione (a tripeptide of 3 amino acids - glutamic acid, cysteine and glycine) plays a great role in homeostasis, especially as a potent anti-oxidant.
As an anti-oxidant, it conjugates with xenobiotics using glutathione-S-transferase (GST) and excretes in urine as mercapturic acid.
In 1986, Casciani et al at the University of Milan, studied the effect of glutathione on blood alcohol, acetaldehyde and hepatic triglyceride levels and found a significant reducing effect.
The blood acetaldehyde, which is the metabolic product of ethyl alcohol may have a correlation with hangover symptoms. This study is designed to find this correlation using blood alcohol, blood acetaldehyde levels and the Hangover Symptoms Scale according to the Slutske et al study.
Condition | Intervention |
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Alcohol Drinking |
Drug: Glutathione |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment |
Estimated Enrollment: | 100 |
Study Start Date: | June 2005 |
Estimated Study Completion Date: | August 2005 |
Type of Study: Double-blinded control
Population: 100 males
Inclusion Criteria:
Exclusion Criteria:
Number of subjects : 100
Methodology
Subjects are examined as follows:
Using Wendy S. Slutske et al Scale 0-4:
0= no symptom
Symptoms are
Blood alcohol, blood acetaldehyde and hangover symptoms are statistically evaluated for significance.
Ages Eligible for Study: | 20 Years to 40 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | sj_1 |
Study First Received: | August 4, 2005 |
Last Updated: | August 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00127309 |
Health Authority: | Thailand: Food and Drug Administration |
hangover hangover symptoms |
Drinking Behavior Alcohol Drinking Ethanol |