![Study Results & Research Projects Study Results & Research Projects](https://webarchive.library.unt.edu/eot2008/20090116132603im_/http://ntp-server.niehs.nih.gov/images/template/subMastHead_studyResults.gif)
Summaries & Associations of Study Results
Summaries & Associations of Study Results
Home » Study Results & Research Projects » Summaries & Associations of Study Results » TR-440 Ozone (2-year study)
CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
---|---|---|---|---|
OZONE 10028-15-6 |
11/16/93 | POLLUTION CONTROL, WASTE TREATMENT, CHEMICAL SYNTHESIS, STERILIZATION WHERE RESIDUALS OF OTHER CHEMICALS WOULD BE OBJECTIONABLE, ODOR CONTROL, BLEACHING WAXES, CLAY, TEXTILES, PAPER PULP, OILS, CONTROL OF ALGAE, MOLD, AND BACTERIA | Inhalation R&M: 0, 0.12, 0.5, OR 1.0 PPM (50/SEX/SPECIES/GROUP) | Battelle Northwest Laboratory |
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
MR: NO EVIDENCE | ||||
NON-NEOPLASTIC LESIONS: | NOSE: (2 YR. STUDY) GOBLET CELL AND LATERAL WALL HYPERPLASIA; SQUAMOUS METAPLASIA | |||
LARYNX: (2 YR. STUDY) SQUAMOUS METAPLASIA | ||||
LUNG: (2 YR. STUDY) METAPLASIA; INTERSTITIAL FIBROSIS | ||||
FR: NO EVIDENCE | ||||
NON-NEOPLASTIC LESIONS: | NOSE: (2 YR. STUDY) GOBLET CELL AND LATERAL WALL HYPERPLASIA; SQUAMOUS METAPLASIA | |||
LARYNX: (2 YR. STUDY) SQUAMOUS METAPLASIA | ||||
LUNG: (2 YR. STUDY) METAPLASIA; INTERSTITIAL FIBROSIS | ||||
MM: EQUIVOCAL EVIDENCE | LUNG: (2 YR. STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 9/50 12/50 11/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 8/50 4/50 8/50 10/50 COMBINED 14/50 13/50 18/50 19/50 | |||
NON-NEOPLASTIC LESIONS: | NOSE: (2 YR. STUDY) HYPERPLASIA; SQUAMOUS METAPLASIA | |||
LARYNX: (2 YR. STUDY) HYPERPLASIA | ||||
LUNG: (2 YR. STUDY) HISTIOCYTIC INFILTRATION; METAPLASIA | ||||
FM: SOME EVIDENCE | LUNG: (2 YR. STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 5/50 5/49 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 2/50 5/49 8/50 COMBINED 6/50 7/50 9/49 16/50 | |||
NON-NEOPLASTIC LESIONS: | NOSE: (2 YR. STUDY) HYPERPLASIA; SQUAMOUS METAPLASIA | |||
LARYNX: (2 YR. STUDY) HYPERPLASIA | ||||
LUNG: (2 YR. STUDY) HISTIOCYCTIC INFILTRATION; METAPLASIA | ||||
OZONE 10028-15-6 |
11/16/93 | POLLUTION CONTROL, WASTE TREATMENT, CHEMICAL SYNTHESIS, STERILIZATION WHERE RESIDUALS OF OTHER CHEMICALS WOULD BE OBJECTIONABLE, ODOR CONTROL, BLEACHING WAXES, CLAY, TEXTILES, PAPER PULP, OILS, CONTROL OF ALGAE, MOLD, AND BACTERIA | Inhalation R&M: 0, 0.5, OR 1.0 PPM (50/SEX/SPECIES/GROUP) | Battelle Northwest Laboratory |
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
MR: NO EVIDENCE | ||||
NON-NEOPLASTIC LESIONS: | NOSE: (LIFETIME STUDY) GOBLET CELL AND LATERAL WALL HYPERPLASIA; SQUAMOUS METAPLASIA | |||
LARYNX: (LIFETIME STUDY) SQUAMOUS METAPLASIA | ||||
LUNG: (LIFETIME STUDY) METAPLASIA; HISTIOCYTIC INFILTRATION; INTERSTITIAL FIBROSIS | ||||
FR: NO EVIDENCE | ||||
NON-NEOPLASTIC LESIONS: | NOSE: (LIFETIME STUDY) GOBLET CELL AND LATERAL WALL HYPERPLASIA; SQUAMOUS METAPLASIA | |||
LARYNX: (LIFETIME STUDY) SQUAMOUS METAPLASIA | ||||
LUNG: (LIFETIME STUDY) METAPLASIA; HISTIOCYTIC INFILTRATION; INTERSTITIAL FIBROSIS | ||||
MM: EQUIVOCAL EVIDENCE | LUNG: (LIFETIME STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 8/49 8/49 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 8/49 15/49 18/50 COMBINED 16/49 22/49 21/50 | |||
NON-NEOPLASTIC LESIONS: | NOSE: (LIFETIME STUDY) HYPERPLASIA; SQUAMOUS METAPLASIA | |||
LARYNX: (LIFETIME STUDY) HYPERPLASIA; SQUAMOUS CELL METAPLASIA | ||||
LUNG: (LIFETIME STUDY) HISTIOCYTIC INFILTRATION; METAPLASIA | ||||
FM: SOME EVIDENCE | LUNG: (LIFETIME STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 3/49 11/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 5/49 2/50 COMBINED 6/50 8/49 12/50 | |||
NON-NEOPLASTIC LESIONS: | NOSE: (LIFETIME STUDY) HYPERPLASIA; SQUAMOUS METAPLASIA | |||
LARYNX: (LIFETIME STUDY) HYPERPLASIA; SQUAMOUS CELL METAPLASIA | ||||
LUNG: (LIFETIME STUDY) HISTIOCYTIC INFILTRATION; METAPLASIA | ||||
OZONE/NNK OZONNNKCOMB |
11/16/93 | BYPRODUCT OF TOBACCO SMOKE | Inhalation MALE RATS ONLY: 0, 0.5 PPM OZONE WITH 0, 0.1, 1.0 MG/KG NNK BY S.C. INJECTION (20 WEEKS ONLY) | Battelle Northwest Laboratory |
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
NOTE: | IN A COCARCINOGENICITY STUDY, OZONE DID NOT ENHANCE NNK-INDUCED PULMONARY NEOPLASMS IN MALE RATS |
Web page last updated on February 10, 2006
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.