National Toxicology Program

CASRN: 10028-15-6

Formula: O3

Synonyms/Common Names:

• TRIATOMIC OXYGEN

Known Uses:

POLLUTION CONTROL, WASTE TREATMENT, CHEMICAL SYNTHESIS, STERILIZATION WHERE RESIDUALS OF OTHER CHEMICALS WOULD BE OBJECTIONABLE, ODOR CONTROL, BLEACHING WAXES, CLAY, TEXTILES, PAPER PULP, OILS, CONTROL OF ALGAE, MOLD, AND BACTERIA

Short-Term Toxicity

• 4-WEEK (Inhalation)  (C88034) Completed 
  • NTIS No. PB95-226999  (Peer Review 11/16/1993)
    Citation: Toxicology and Carcinogenesis Studies of Ozone (CAS No. 10028-15-6) and Ozone/NNK (CAS No. 10028-15-6/ 64091-91-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.5, OR 1.0 PPM (5/SEX/SPECIES/GROUP)

Long-Term Carcinogenicity

• LIFETIME (Inhalation)  (C88034B) Report Complete 
  • TR-440 (NTIS No. PB95-226999)  (Peer Review 11/16/1993)
    Toxicology and Carcinogenesis Studies of Ozone (CAS No. 10028-15-6) and Ozone/NNK (CAS No. 10028-15-6/ 64091-91-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice Equivocal Evidence 
  • Female Mice Some Evidence 
  • Dose: R&M: 0, 0.5, OR 1.0 PPM (50/SEX/SPECIES/GROUP)
• 2-YEAR (Inhalation)  (C88034) Report Complete 
  • TR-440 (NTIS No. PB95-226999)  (Peer Review 11/16/1993)
    Toxicology and Carcinogenesis Studies of Ozone (CAS No. 10028-15-6) and Ozone/NNK (CAS No. 10028-15-6/ 64091-91-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice Equivocal Evidence 
  • Female Mice Some Evidence 
  • Dose: R&M: 0, 0.12, 0.5, OR 1.0 PPM (50/SEX/SPECIES/GROUP)

Genetic Toxicology

• Salmonella  (A31529) Completed 
  •  Positive