Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsors and Collaborators: |
Hamilton Health Sciences Heart and Stroke Foundation of Ontario |
---|---|
Information provided by: | McMaster University |
ClinicalTrials.gov Identifier: | NCT00279227 |
We sight to evaluate whether patients with coronary artery disease (CAD) have more epicardial fat than patients without CAD, which would suggest that epicardial fat may be more than an “innocent bystander” and be actively involved in the disease process. Its role as a modulator of vascular response and myocardial function could potentially lead to new areas of cardiac research. We also sight to evaluate whether epicardial fat from patients with CAD releases more adipokines than subcutaneous fat from these patients which could prompt studies into the differential regulation of adipokine secretion in this tissue. Thus for e.g., the use of thiazolidinediones (glitazones), statins, ARBs or other compounds that can specifically modulate adipokine secretion could be explored to determine their benefit in ameliorating the effects attributable to increased epicardial fat.
Condition |
---|
Coronary Artery Disease Obesity |
Study Type: | Observational |
Study Design: | Natural History, Cross-Sectional, Defined Population, Prospective Study |
Official Title: | Role of Epicardial Adipose Tissue in Coronary Artery Disease |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Suzana Damjanovic, MLT, CCRA | 905-527-4322 ext 44710 | suzana@cardio.on.ca |
Canada, Ontario | |
Hamilton Health Sciences - Cardiovascular Obesity Research and Management Center | Recruiting |
Hamilton, Ontario, Canada, L8L 2X2 | |
Sub-Investigator: Gianluca Iacobellis, MD PhD | |
Principal Investigator: Arya M Sharma, MD FRCPC |
Principal Investigator: | Arya M Sharma, MD, FRCPC | McMaster University |
Study ID Numbers: | EPICARD Study |
Study First Received: | January 17, 2006 |
Last Updated: | August 9, 2006 |
ClinicalTrials.gov Identifier: | NCT00279227 |
Health Authority: | Canada: Health Canada |
coronary artery disease epicardial adipose tissue epicardial fat obesity |
Arterial Occlusive Diseases Obesity Heart Diseases Myocardial Ischemia Vascular Diseases Overweight Ischemia |
Arteriosclerosis Coronary Disease Body Weight Signs and Symptoms Nutrition Disorders Overnutrition Coronary Artery Disease |
Cardiovascular Diseases |