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Sponsored by: |
Medical University of Vienna |
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Information provided by: | Medical University of Vienna |
ClinicalTrials.gov Identifier: | NCT00787631 |
A high number of birch pollen-allergic individuals develop hypersensitivity reactions to certain foods, e.g. apples. This food allergy is due to immunological cross-reactivity. Birch pollen-related foods contain proteins, e.g. Mal d 1 in apple, that are structurally related with the major birch pollen allergen, Bet v 1. Hence IgE antibodies and T lymphocytes specific for Bet v 1 recognize these food proteins which results in activation of the immune system and, consequently, in clinical symptoms.
In the present study the investigators intend to investigate if and how the consumption of birch pollen-related food allergens affects birch pollen allergy. In other words, the investigators are interested to analyse whether Bet v 1-related food allergens activate Bet v 1-specific memory cells and thus, contribute to the maintenance of the pollen allergy outside the pollen season. Data obtained in this study will help to clarify the immunological and clinical role of cross-reactivity between pollen and food allergies and will reveal whether avoidance of such foods should be recommended for the patients. Finally, novel approaches for diagnosis and therapy of pollen-related food allergens can be developed.
Condition |
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Allergic Rhinitis Food Allergy |
Study Type: | Observational |
Study Design: | Case-Only, Prospective |
Official Title: | Analysis of Immunological Reactions to Pollen-Related Foods in Birch Pollen-Allergic Patients |
Ages Eligible for Study: | 18 Years to 50 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
otherwise healthy birch pollen allergic (rhinoconjunctivitis)persons suffering also from oral allergy syndrome to apple.
Inclusion Criteria:
Exclusion Criteria:
Contact: Tamar Kinaciyan, Ass.Prof.MD | +43140400 ext 7700 | tamar.kinaciyan@meduniwien.ac.at |
Contact: Barbara Bohle, AssocProf Dr | +43140400 ext 5114 | barbara.bohle@meduniwien.ac.at |
Principal Investigator: | Tamar Kinaciyan, Ass Prof MD | Dept. of Dermatology, Medical University of Vienna |
Responsible Party: | DIAID, Dep. of Dermatology, MUV ( Tamar Kinaciyan, MD, Ass. Prof. ) |
Study ID Numbers: | TK01/2008 |
Study First Received: | October 23, 2008 |
Last Updated: | November 6, 2008 |
ClinicalTrials.gov Identifier: | NCT00787631 |
Health Authority: | Austria: Federal Office for Safety in Health Care |
birch pollen pollen allergy oral allergy syndrome to apple cross reactivity bet v 1 mal d 1 |
Food Hypersensitivity Hypersensitivity Otorhinolaryngologic Diseases Respiratory Tract Infections |
Respiratory Tract Diseases Rhinitis, Allergic, Seasonal Hypersensitivity, Immediate Rhinitis |
Immune System Diseases Nose Diseases |