Behavioral Neuroscience Research Branch
Behavioral Neuroscience Section
Mission Statement
The mission of the Behavioral Neuroscience Branch is to characterize the brain circuitry involved in the habit-forming actions of drugs of abuse. We want to identify the circuit elements anatomically and neurochemically and to identify their functions in normal motivated behavior.
Program Areas
• Brain reward circuitry associated with brain stimulation and intravenous drug reward
• Neuroadaptations in the reward circuitry resulting from drug experience
• Electrophysiology of drug self-administration
• Knockout mouse models of drug abuse
Name: Roy Wise, Ph.D.
Title: Chief, Behavioral Neuroscience Research Branch
Telephone Number: (410) 550-1303
Synopsis of Research
My interest is in the role of afferents to and efferents from the mesolimbic dopamine system and their role in drug reward. We use microdialysis, single cell recording, and behavioral assays to monitor the function of these circuits, and intravenous and intracranial drug injections and intracranial electrical stimulation to manipulate them. We also work with mutant mice with receptor or transporter deletions in these systems. Finally, we study neuroadaptations in intracellular messenger cascades in the reward circuitry of drug-experienced and drug-naive animals.
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Behavioral Neuroscience Research Branch
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