Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsors and Collaborators: |
Bayside Health Baker Heart Research Institute The Alfred |
---|---|
Information provided by: | Bayside Health |
ClinicalTrials.gov Identifier: | NCT00485368 |
The purpose of this research is to assess the effects of a drug called perindopril on the aorta in people known to have Marfan Syndrome. The aorta is the major artery of the body that comes out of the heart and supplies blood to the body. We know that in people with Marfan Syndrome, the aorta is stiff and this stiffness results in its enlargement over many years. This enlargement of the aorta can be very serious. We know from treatment of other heart conditions that drugs of the same type as perindopril reduce stiffness of the arteries. This type of drug has never been tried in people with Marfan Syndrome.
Condition | Intervention | Phase |
---|---|---|
Marfan Syndrome |
Drug: Coversyl (perindopril) |
Phase III |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study |
Official Title: | The Effect of an Angiotensin Converting Enzyme Inhibitor on Aortic Wall Properties in Patients With Marfan Syndrome. |
Ages Eligible for Study: | 18 Years to 40 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | 3/03 |
Study First Received: | June 11, 2007 |
Last Updated: | June 12, 2007 |
ClinicalTrials.gov Identifier: | NCT00485368 |
Health Authority: | Australia: Department of Health and Ageing Therapeutic Goods Administration |
marfan syndrome aortic root diameter |
Perindopril Heart Diseases Cardiovascular Abnormalities Marfan syndrome Marfan Syndrome Bone Diseases Musculoskeletal Abnormalities Musculoskeletal Diseases |
Genetic Diseases, Inborn Bone Diseases, Developmental Abnormalities, Multiple Connective Tissue Diseases Congenital Abnormalities Heart Defects, Congenital Arachnodactyly |
Disease Molecular Mechanisms of Pharmacological Action Enzyme Inhibitors Cardiovascular Agents Antihypertensive Agents Pharmacologic Actions Protease Inhibitors |
Limb Deformities, Congenital Pathologic Processes Syndrome Therapeutic Uses Angiotensin-Converting Enzyme Inhibitors Cardiovascular Diseases |