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Sponsored by: |
National Taiwan University Hospital |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00745888 |
In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness. First, the investigators want to search out the effects of the past history, smoking, alcohol drinking, use of antioxidants, different diseases, and different duration of SIRS on the degree of oxidative stress. Second, besides total count of ROS, the investigators used new techniques to determine superoxide(O2●-), hydrogen peroxide (H2O2), and hypochlorous acid(HOCl). Furthermore, we want to investigate the correlation of the degree of different reactive oxygen species and the severity of SIRS or shock. Third, we try to investigate the correlation between the change of oxidative stress and the prognosis of the patients.
The investigators wish this study will help them to investigate the effect of oxidative stress on critical ill patients, to modulate the oxidative stress, to decrease the occurrence of SIRS, shock, and multiorgan failure, and to improve the long term outcome of patients.
Condition | Intervention | Phase |
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Sepsis Shock |
Other: Chemiluminescence Analyzer |
Phase III |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit |
blood sample
Estimated Enrollment: | 200 |
Study Start Date: | May 2007 |
Groups/Cohorts | Assigned Interventions |
---|---|
1
age > 18 y/o Patients admitted to surgical ICU
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Other: Chemiluminescence Analyzer
measure reactive oxygen species
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Patients admitted to surgical ICU
Inclusion Criteria:
Exclusion Criteria:
Contact: Yu-Chang Yeh, MD | 886-9-68661829 | tonyyeh@ntuh.gov.tw |
Taiwan | |
National Taiwan University Hospital | Recruiting |
Taipei, Taiwan, 100 | |
Contact: Yu-Chang Yeh, MD 886-9-68661829 tonyyeh@ntuh.gov.tw | |
Principal Investigator: Yu-Chang Yeh, MD |
Principal Investigator: | Yu-Chang Yeh | National Taiwan University Hospital |
Responsible Party: | National Taiwan University Hospital ( Yu-Chang Yeh ) |
Study ID Numbers: | 9561709132 |
Study First Received: | September 2, 2008 |
Last Updated: | November 24, 2008 |
ClinicalTrials.gov Identifier: | NCT00745888 |
Health Authority: | Taiwan: Department of Health |
oxidative stress intensive care Postoperative intensive care |
Sepsis Shock Stress |