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Sponsored by: |
University of Sydney |
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Information provided by: | University of Sydney |
ClinicalTrials.gov Identifier: | NCT00465660 |
Female subjects over the age of 40 will be recruited and randomised into a progressive resistance training (PRT) or sham-exercise group. The PRT group will train at 80% of their peak strength, using Keiser pneumatic resistance machines, and progress approximately 3% per session. Strength will be re-assessed fortnightly. Exercises will target muscles around the hip and knee. The sham-exercise group will train on the same equipment as the PRT group except hip adduction, but without added resistance or progression. Both groups will train 3 days per week for roughly 45 minutes for 6 months.
It is hypothesised that high intensity PRT will decelerate the tibial and femoral cartilage degeneration in the knee affected most by OA.
Primary Outcome:
Articular cartilage morphology following 6 months high intensity progressive resistance training
Secondary Outcomes:
Muscle and fat cross-sectional area (CSA) (pre and post) Muscle strength, power, endurance, and contraction velocity (pre, 3 months, & post) Medications (pre, 3 months, & post) Body composition (pre, 3 months, & post) Balance; Physical function (pre, 3 months, & post) Questionnaires (pre, 3 months, & post)
Condition | Intervention | Phase |
---|---|---|
Osteoarthritis |
Behavioral: Progressive resistance training |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | The Effect of 6 Month High Intensity Progressive Resistance Training on Knee Articular Cartilage Morphology in Female Osteoarthritic Patients |
Estimated Enrollment: | 60 |
Study Start Date: | April 2005 |
Estimated Study Completion Date: | July 2009 |
Ages Eligible for Study: | 40 Years and older |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Australia, New South Wales | |
University of Sydney | |
Sydney, New South Wales, Australia, 2140 |
Principal Investigator: | Benedicte Vanwanseele, PhD | University of Sydney |
Study ID Numbers: | ACTRN012605000116628 |
Study First Received: | April 24, 2007 |
Last Updated: | April 24, 2007 |
ClinicalTrials.gov Identifier: | NCT00465660 |
Health Authority: | Australia: Human Research Ethics Committee |
Osteoarthritis Cartilage Exercise Progressive Resistance Training |
Musculoskeletal Diseases Osteoarthritis Joint Diseases Arthritis Rheumatic Diseases |