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Sponsored by: |
Universitaire de Sherbrooke |
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Information provided by: | Universitaire de Sherbrooke |
ClinicalTrials.gov Identifier: | NCT00269685 |
The purpose of this study is to compare the classical tactics in the treatment of septic shock (dopamine, noradrenalin and dobutamine) to the use of vasopressin as first choice pressor.
Vasopressin seems to be an interesting alternative in the treatment of septic shock. To this date, available studies have showed that it could correct hyperkinetic syndrome and vasoplegia in septic shocks without noticeable side effect. It as been demonstrated that vasopressin improves renal function, as no effect on digestive organs and as no metabolic effect.
Condition | Intervention | Phase |
---|---|---|
Shock, Septic |
Drug: vasopressin |
Phase II Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Single Group Assignment, Safety Study |
Official Title: | Comparative Prospective Study of Vasopressin and Catecholamine in Septic Shock |
Estimated Enrollment: | 20 |
Study Start Date: | July 2000 |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
The time window between beginning of symptoms and onset of treatment is established at 12 hours.
The patient must be intubated and mechanically ventilated.
Patient presenting a mean arterial blood pressure of less than 60 mm Hg after adequate fluid resuscitation (at least 1 L of colloid or crystalloid) and 10 ug/Kg/min of dopamine.
Patient presenting a cardiac index of at least 3 L/min/m2
Exclusion Criteria:
Study ID Numbers: | 00-33-R2 |
Study First Received: | December 22, 2005 |
Last Updated: | May 26, 2006 |
ClinicalTrials.gov Identifier: | NCT00269685 |
Health Authority: | Canada: Health Canada |
Septic shock catecholamine vasopressin tonometria lactate |
Arginine Vasopressin Systemic Inflammatory Response Syndrome Sepsis Shock |
Shock, Septic Vasopressins Inflammation |
Pathologic Processes Coagulants Natriuretic Agents Therapeutic Uses Physiological Effects of Drugs Hematologic Agents |
Vasoconstrictor Agents Cardiovascular Agents Antidiuretic Agents Infection Pharmacologic Actions Hemostatics |