Evaluation of Patients Treated With Natalizumab Finds No New Cases of Progressive Multifocal LeukoencephalopathyWednesday, Mar 1, 2006
An independent clinical and laboratory study of more than 3000 people treated with the drug natalizumab (Tysabri®) for multiple
sclerosis (MS), Crohn’s disease, and rheumatoid arthritis has found no evidence of new cases of the often-fatal disorder called
progressive multifocal leukoencephalopathy (PML). The laboratory component of the study was coordinated by the National Institute
of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH), working in conjunction with the NIH
Clinical Center.
Evaluation of Patients Treated With Natalizumab Finds No New Cases of Progressive Multifocal LeukoencephalopathyWednesday, Mar 1, 2006
An independent clinical and laboratory study of more than 3000 people treated with the drug natalizumab (Tysabri®) for multiple
sclerosis (MS), Crohn’s disease, and rheumatoid arthritis has found no evidence of new cases of the often-fatal disorder called
progressive multifocal leukoencephalopathy (PML). The laboratory component of the study was coordinated by the National Institute
of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH), working in conjunction with the NIH
Clinical Center.
Test Could Improve Detection of Prion Disease in HumansMonday, Feb 14, 2005
A highly sensitive post-mortem test could help scientists more accurately determine if a person died of Creutzfeldt-Jakob
disease (CJD), a human neurological disorder caused by the same class of infectious proteins that trigger mad cow disease,
according to a new study supported in part by the National Institutes of Health (NIH). The finding opens the possibility that
such testing might be refined in the future so it can be used to detect prion disease in living people and animals before
the onset of symptoms.
Serotonin Receptor Lets JC Virus Enter Brain CellsFriday, Jan 14, 2005
Researchers funded in part by the National Institute of Neurological Disorders and Stroke (NINDS) have identified the cellular
receptor for the JC virus, which causes the fatal neurological disease progressive multifocal leukoencephalopathy (PML).
Generic medicines currently available may be useful in preventing the infection.
Serotonin Receptor Lets JC Virus Enter Brain CellsFriday, Jan 14, 2005
Researchers funded in part by the National Institute of Neurological Disorders and Stroke (NINDS) have identified the cellular
receptor for the JC virus, which causes the fatal neurological disease progressive multifocal leukoencephalopathy (PML).
Generic medicines currently available may be useful in preventing the infection.
Pressure Combined with Heat Reduces Prion Infectivity in Processed MeatsMonday, May 5, 2003
The combination of high temperature and very high pressure in the preparation of processed meats such as hot dogs and salami
may effectively reduce the presence of infective prions while retaining the taste, texture, and look of these meats, according
to a new study.
Fact Sheet Study Detects Brain Virus in HIV-Positive PatientsTuesday, May 5, 1992
Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) have identified a potentially fatal virus
in the bloodstream in half of a small group of HIV-positive patients without neurological symptoms, they announced today at
the annual meeting of the American Academy of Neurology in San Diego.
Long-Time NIH Grantee Stanley B. Prusiner Wins Nobel PrizeMonday, Oct 6, 1997
Stanley B. Prusiner, M.D., a long-time grantee of the National Institutes of Health (NIH), is the recipient of the 1997 Nobel
Prize in physiology or medicine for his discovery of an unusual class of infectious particles called prions. Prions are believed
to be responsible for a group of diseases that include "mad cow" disease. Prusiner, who is professor of neurology, virology,
and biochemistry at the University of California, San Francisco (UCSF), has received more than 56 million dollars in research
grant support from NIH during the last three decades.
Protein Marker Found in Transmissible Spongiform Encephalopathies: Finding May Lead to Diagnostic Test for Human, Cattle
DisordersWednesday, Sep 25, 1996
A protein widely distributed in tissues throughout the body, with the highest concentration in the brain, has been shown to
be a specific marker in the spinal fluid of humans and animals infected with transmissible spongiform encephalopathies, scientists
say. This discovery paves the way for the development of an improved test for the diagnosis of Creutzfeldt-Jakob disease
in humans and encephalopathies in animals. The test could enable precise identification of disease in British cattle presently
targeted for slaughter because of suspected infection with bovine spongiform encephalopathy, known as Mad Cow disease.
Pressure Combined with Heat Reduces Prion Infectivity in Processed MeatsMonday, May 5, 2003
The combination of high temperature and very high pressure in the preparation of processed meats such as hot dogs and salami
may effectively reduce the presence of infective prions while retaining the taste, texture, and look of these meats, according
to a new study.
Fact Sheet Long-Time NIH Grantee Stanley B. Prusiner Wins Nobel PrizeMonday, Oct 6, 1997
Stanley B. Prusiner, M.D., a long-time grantee of the National Institutes of Health (NIH), is the recipient of the 1997 Nobel
Prize in physiology or medicine for his discovery of an unusual class of infectious particles called prions. Prions are believed
to be responsible for a group of diseases that include "mad cow" disease. Prusiner, who is professor of neurology, virology,
and biochemistry at the University of California, San Francisco (UCSF), has received more than 56 million dollars in research
grant support from NIH during the last three decades.
Protein Marker Found in Transmissible Spongiform Encephalopathies: Finding May Lead to Diagnostic Test for Human, Cattle
DisordersWednesday, Sep 25, 1996
A protein widely distributed in tissues throughout the body, with the highest concentration in the brain, has been shown to
be a specific marker in the spinal fluid of humans and animals infected with transmissible spongiform encephalopathies, scientists
say. This discovery paves the way for the development of an improved test for the diagnosis of Creutzfeldt-Jakob disease
in humans and encephalopathies in animals. The test could enable precise identification of disease in British cattle presently
targeted for slaughter because of suspected infection with bovine spongiform encephalopathy, known as Mad Cow disease.
Study Detects Brain Virus in HIV-Positive PatientsTuesday, May 5, 1992
Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) have identified a potentially fatal virus
in the bloodstream in half of a small group of HIV-positive patients without neurological symptoms, they announced today at
the annual meeting of the American Academy of Neurology in San Diego.