Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders
This protocol will explore pathogenic mechanisms for systemic rheumatic disorders and possible elemental disorders through the evaluation of families with monozygotic or dizygotic twins or other siblings discordant for systemic rheumatic disorders (twin-sib pairs). Parents, normal volunteers and offspring of microchimeric female twin-sibs will also be evaluated as needed for the experimental designs of each portion of the protocol. (details (http://www.niehs.nih.gov/research/clinical/join/bethesda/physicians/ph-psftsdsrd.cfm))
Studies in the Natural History and Pathogenesis of Childhood Idiopathic Inflammatory Myopathies
This study will evaluate subjects with childhood-onset Myositis to learn more about their cause and the immune system changes and medical problems associated with them. A secondary goal is to better define the complications of illness and how to best assess these. Myositis is an inflammatory muscle disease that can damage muscles and other organs, resulting in significant disability. The hope is that such studies will allow for better treatments or even the prevention of these diseases. (details (http://www.niehs.nih.gov/research/clinical/join/bethesda/physicians/ph-snhpciim.cfm))
Studies on Tissues from Patients with Fibrous Dysplasia of Bone / McCune Albright Syndrome and Other Disorders of Calcified Tissues
This study will examine calcinosis samples that have been surgically removed from patients with juvenile Dermatomyositis . The removed tissues will be examined for their composition and microscopic appearance, to better understand the pathogenesis of dystrophic calcification in this disease. Patients who are scheduled to have surgery for removal of calcinosis may participate in this study. (details (http://www.niehs.nih.gov/research/clinical/join/bethesda/physicians/ph-stpfdbmasod.cfm))
Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders
This protocol will explore pathogenic mechanisms for systemic rheumatic disorders and possible elemental disorders through the evaluation of families with monozygotic or dizygotic twins or other siblings discordant for systemic rheumatic disorders (twin-sib pairs). Parents, normal volunteers and offspring of microchimeric female twin-sibs will also be evaluated as needed for the experimental designs of each portion of the protocol. (details (http://www.niehs.nih.gov/research/clinical/join/bethesda/physicians/ph-psftsdsrd.cfm))
Studies in the Natural History and Pathogenesis of Childhood Idiopathic Inflammatory Myopathies
This study will evaluate subjects with childhood-onset Myositis to learn more about their cause and the immune system changes and medical problems associated with them. A secondary goal is to better define the complications of illness and how to best assess these. Myositis is an inflammatory muscle disease that can damage muscles and other organs, resulting in significant disability. The hope is that such studies will allow for better treatments or even the prevention of these diseases. (details (http://www.niehs.nih.gov/research/clinical/join/bethesda/physicians/ph-snhpciim.cfm))
Studies on Tissues from Patients with Fibrous Dysplasia of Bone / McCune Albright Syndrome and Other Disorders of Calcified Tissues
This study will examine calcinosis samples that have been surgically removed from patients with juvenile Dermatomyositis . The removed tissues will be examined for their composition and microscopic appearance, to better understand the pathogenesis of dystrophic calcification in this disease. Patients who are scheduled to have surgery for removal of calcinosis may participate in this study. (details (http://www.niehs.nih.gov/research/clinical/join/bethesda/physicians/ph-stpfdbmasod.cfm))
B. Inclusion Body Myositis (juvenile & adult)
Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders
This protocol will explore pathogenic mechanisms for systemic rheumatic disorders and possible elemental disorders through the evaluation of families with monozygotic or dizygotic twins or other siblings discordant for systemic rheumatic disorders (twin-sib pairs). Parents, normal volunteers and offspring of microchimeric female twin-sibs will also be evaluated as needed for the experimental designs of each portion of the protocol. (details (http://www.niehs.nih.gov/research/clinical/join/bethesda/physicians/ph-psftsdsrd.cfm))
C. Polymyositis (juvenile & adult)
Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders
This protocol will explore pathogenic mechanisms for systemic rheumatic disorders and possible elemental disorders through the evaluation of families with monozygotic or dizygotic twins or other siblings discordant for systemic rheumatic disorders (twin-sib pairs). Parents, normal volunteers and offspring of microchimeric female twin-sibs will also be evaluated as needed for the experimental designs of each portion of the protocol. (details (http://www.niehs.nih.gov/research/clinical/join/bethesda/physicians/ph-psftsdsrd.cfm))
Studies in the Natural History and Pathogenesis of Childhood Idiopathic Inflammatory Myopathies
This study will evaluate subjects with childhood-onset Myositis to learn more about their cause and the immune system changes and medical problems associated with them. A secondary goal is to better define the complications of illness and how to best assess these. Myositis is an inflammatory muscle disease that can damage muscles and other organs, resulting in significant disability. The hope is that such studies will allow for better treatments or even the prevention of these diseases. (details (http://www.niehs.nih.gov/research/clinical/join/bethesda/physicians/ph-snhpciim.cfm))
Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders
This protocol will explore pathogenic mechanisms for systemic rheumatic disorders and possible elemental disorders through the evaluation of families with monozygotic or dizygotic twins or other siblings discordant for systemic rheumatic disorders (twin-sib pairs). Parents, normal volunteers and offspring of microchimeric female twin-sibs will also be evaluated as needed for the experimental designs of each portion of the protocol. (details (http://www.niehs.nih.gov/research/clinical/join/bethesda/physicians/ph-psftsdsrd.cfm))
3. Systemic Lupus Erythematosus (Lupus)
Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders
This protocol will explore pathogenic mechanisms for systemic rheumatic disorders and possible elemental disorders through the evaluation of families with monozygotic or dizygotic twins or other siblings discordant for systemic rheumatic disorders (twin-sib pairs). Parents, normal volunteers and offspring of microchimeric female twin-sibs will also be evaluated as needed for the experimental designs of each portion of the protocol. (details (http://www.niehs.nih.gov/research/clinical/join/bethesda/physicians/ph-psftsdsrd.cfm))
4. Systemic Sclerosis (Scleroderma)
Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders
This protocol will explore pathogenic mechanisms for systemic rheumatic disorders and possible elemental disorders through the evaluation of families with monozygotic or dizygotic twins or other siblings discordant for systemic rheumatic disorders (twin-sib pairs). Parents, normal volunteers and offspring of microchimeric female twin-sibs will also be evaluated as needed for the experimental designs of each portion of the protocol. (details (http://www.niehs.nih.gov/research/clinical/join/bethesda/physicians/ph-psftsdsrd.cfm))
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