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Sponsored by: |
Kantonsspital Graubünden |
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Information provided by: | Kantonsspital Graubünden |
ClinicalTrials.gov Identifier: | NCT00536068 |
Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.
Condition | Intervention |
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Hemostasis |
Drug: Acetylsalicylic acid, acetaminophen, diclofenac, naproxen, placebo |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Single Blind (Subject), Placebo Control, Parallel Assignment, Efficacy Study |
Enrollment: | 11 |
Study Start Date: | August 2006 |
Study Completion Date: | August 2007 |
Arms | Assigned Interventions |
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1, 2, 3, 4: Experimental
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Drug: Acetylsalicylic acid, acetaminophen, diclofenac, naproxen, placebo
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An in vivo study on healthy volunteers with combinations of well established drugs
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Switzerland | |
Kantonsspital Graubünden, Department of Internal Medicine | |
Chur, Switzerland, CH 7000 |
Principal Investigator: | Walter H Reinhart, MD Professor | Department of Internal Medicine, Kantonsspital Graubunden CH7000 Chur Switzerland |
Study ID Numbers: | KGWR0206 |
Study First Received: | September 26, 2007 |
Last Updated: | September 27, 2007 |
ClinicalTrials.gov Identifier: | NCT00536068 |
Health Authority: | Switzerland: Swissmedic |
platelet aggregation aspirin |
Naproxen Aspirin Diclofenac Acetaminophen |
Anti-Inflammatory Agents Molecular Mechanisms of Pharmacological Action Cyclooxygenase Inhibitors Hematologic Agents Physiological Effects of Drugs Enzyme Inhibitors Fibrinolytic Agents Cardiovascular Agents Pharmacologic Actions Fibrin Modulating Agents |
Analgesics, Non-Narcotic Sensory System Agents Therapeutic Uses Platelet Aggregation Inhibitors Anti-Inflammatory Agents, Non-Steroidal Analgesics Peripheral Nervous System Agents Antirheumatic Agents Central Nervous System Agents |