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Sponsors and Collaborators: |
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) University of Florida Emory University Medical University of South Carolina University of South Carolina |
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Information provided by: | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
ClinicalTrials.gov Identifier: | NCT00649246 |
This is an observational study designed to help researchers understand the genetics and pathogenesis of type 1 diabetes, and to identify biomarkers for disease and disease complication prediction.
Condition |
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Type 1 Diabetes Autoimmunity |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | 1. Prospective Studies in Infants of the Immunopathogenesis of Type 1 Diabetes 2. Consortium for Identification of Environmental Triggers of Type 1 Diabetes: MCG/UF Clinical Center 3. Identification of Serum Protein Markers for Type 1 Diabetes Using Mass-Spectrometry Techniques 4. Validation of Microarray-Based Biomarkers for Type 1 Diabetes 5. Development of Microarray-Based Biomarkers for Type 1 Diabetes 6. Proteomic Changes/Progression of Human Type 1 Diabetes 7. Identification and Validation of Serum Biomarkers for T1D |
whole blood, DNA, serum, RNA, urine
Estimated Enrollment: | 50000 |
Study Start Date: | July 1997 |
Groups/Cohorts |
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1
controls: healthy individuals with no family history of type 1 diabetes |
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high-risk: Subjects with islet autoantibodies or high-risk diabetes genes |
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type 1 diabetes: subjects with type 1 diabetes |
This study is designed to identify people who are at risk for developing type 1 diabetes, based on their genetics, family history and autoimmunity status, and to understand the role genetics plays in the development of the complications associated with type 1 diabetes in patients already affected by type 1 diabetes.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
newborns, young children, adults with or without type 1 diabetes
Inclusion Criteria: all are welcome -
Exclusion Criteria:
-
Contact: Diane I Hopkins, MS, CCRC | 706-721-4161 | dhopkins@mcg.edu |
Contact: Leigh Steed, RN, CCRA | 404-252-0844 | lsteed@mcg.edu |
United States, Florida | |
University of Florida | Recruiting |
Gainesville, Florida, United States, 32608 | |
Contact: Angie Choate, BS 352-334-0843 choatal@peds.ufl.edu | |
Contact: Angela Wilcox, BS 352-334-0843 | |
Principal Investigator: Desmond Schatz, MD | |
United States, South Carolina | |
Medical University of South Carolina | Recruiting |
Charleston, South Carolina, United States, 29425 | |
Contact: Lori Spillers, RN 843-792-8166 spillerl@musc.edu | |
Principal Investigator: Louis Luttrel, MD | |
University of South Carolina | Recruiting |
Columbia, South Carolina, United States, 29208 | |
Contact: Joan Thomas 803-251-7870 jthomas@gwm.sc.edu | |
Principal Investigator: Elizabeth Mayer-Davis, PhD |
Principal Investigator: | Jin Xiong She, PhD | Medical College of Georgia |
Responsible Party: | Center for Biotechnology and Genomic Medicine at the Medical College of Georgia ( Jin Xiong She Ph.D. ) |
Study ID Numbers: | DK63865 - PANDA |
Study First Received: | March 28, 2008 |
Last Updated: | September 16, 2008 |
ClinicalTrials.gov Identifier: | NCT00649246 |
Health Authority: | United States: Federal Government |
genetics type 1 diabetes biomarkers autoimmunity |
Autoimmune Diseases Metabolic Diseases Diabetes Mellitus, Type 1 Disease Progression Diabetes Mellitus |
Endocrine System Diseases Endocrinopathy Metabolic disorder Glucose Metabolism Disorders |
Immune System Diseases |