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Sponsors and Collaborators: |
National Institute on Drug Abuse (NIDA) University of Pennsylvania |
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Information provided by: | National Institute on Drug Abuse (NIDA) |
ClinicalTrials.gov Identifier: | NCT00000352 |
The purpose of this study is to determine if addition of dextromethorphan to a stable dose of methadone in opioid dependent subjects will significantly affect physical and psychological aspects of opioid tolerance.
Condition | Intervention | Phase |
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Opioid-Related Disorders Substance-Related Disorders |
Drug: Dextromethorphan |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment |
Official Title: | Effects of Dextromethorphan on Opioid Tolerance in Methadone Patients |
Ages Eligible for Study: | 21 Years to 55 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Please contact site for information.
United States, Pennsylvania | |
University of Pennsylvania | |
Philadelphia, Pennsylvania, United States, 19104 6178 |
Principal Investigator: | Charles O'Brien, M.D., Ph.D. | PDVAMC Treatment Research Center |
Study ID Numbers: | NIDA-3-0012-1, Y01-3-0012-1 |
Study First Received: | September 20, 1999 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00000352 |
Health Authority: | United States: Federal Government |
Naphazoline Oxymetazoline Excitatory Amino Acids Methadone Guaifenesin Phenylephrine |
Mental Disorders Dextromethorphan Substance-Related Disorders Disorders of Environmental Origin Phenylpropanolamine Opioid-Related Disorders |
Respiratory System Agents Neurotransmitter Agents Pathologic Processes Disease Molecular Mechanisms of Pharmacological Action Therapeutic Uses |
Physiological Effects of Drugs Excitatory Amino Acid Agents Antitussive Agents Central Nervous System Agents Pharmacologic Actions Excitatory Amino Acid Antagonists |