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 Thursday, March 22, 2007     Volume 18   Number 12  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on disease prevention & public health.
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Mid-West Community Genetics Forum
The Center for Public Health and Community Genomics (CPHCG) at the University of Michigan is launching a new forum to engage and educate Midwest communities on genomics and encourage feedback on issues of genomic research and practice. Read more.

CDC Announcements
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Addressing the Obesity Epidemic: A Genomics Perspective
Newly published article in CDC's Preventing Chronic Disease journal by the Genetics Program This reference links to a non-governmental website of the Oregon Department of Human Services. This article "emphasizes the multifactorial nature of common obesity, which is caused by the interaction of genes, environment, and lifestyle."

The Oregon Genetics Program was established in 2000, and is primarily supported through a cooperative agreement with CDC's National Office of Public Health Genomics.

   
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What’s New in HuGENet™
March 2007

 
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Deadly Medicine: Creating the Master Race   This reference links to a non-governmental website
The national traveling exhibit “Deadly Medicine, Creating the Master Race,” created by the U.S. Holocaust Memorial Museum, This reference links to a non-governmental website documents 20th century eugenics worldwide, focusing on Nazi Germany. This exhibit will be displayed in CDC's Global Health Odyssey in the Tom Harkin Global Communications Center from April 30th to August 10th, 2007.

 
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CDC request for applications on Improving Public Health Practice through Translation Research (R18)
The purpose of the RFA is the achievement of new scientific knowledge that can accelerate the translation of research findings into public health practice through implementation, dissemination, and diffusion research. Components are included from various CDC offices and centers. Genomics translation research priorities include family history, genetic testing, and genetics for early disease detection and intervention.
   
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Congress moves to ban genetic discrimination”  This reference links to a non-governmental website
(Mar 21) NPR reports, “On Capitol Hill, Congress is on the verge of breaking a 12-year impasse over legislation that would ban the use of genetic information by employers and health insurers.”

“A visionary who led a genetic revolution”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 22) Los Angeles Times reports, “When Milton Wexler's ex-wife lurched across a downtown Los Angeles street one day almost 40 years ago, a police officer called out to her, "Aren't you ashamed of drinking so early in the morning?”

“Unilab probes genes’ link to high cholesterol”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 21) Philstar.com reports, “Filipino scientists at leading pharmaceutical company United Laboratories Inc. are now looking at genes associated with cardiovascular diseases to determine more responsive treatment methods for Filipinos with high cholesterol.”

“Lawmakers seek regulations, standards for home DNA kits”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 21) The Sun-Sentinel reports, “With the click of a mouse, consumers can buy DNA tests that claim to do everything from pinpointing risks for life-threatening diseases like cancer to steering them to a healthier lifestyle through dietary supplements -- all in the comfort and privacy of their homes.”

“The genome's quirky genius”  This reference links to a non-governmental website
(Mar 21) The Australian reports, “The meaning of "gene" is as shifting and elusive as anything dreamed of in literary theory. The gene has come a long way in recent years.”

“DNA nanoparticles hold promise in gene therapy for Parkinson's disease”  This reference links to a non-governmental website
(Mar 20) Science Daily reports, “University of Kentucky researcher David Yurek was recently awarded $66,000 by The Michael J. Fox Foundation for Parkinson's Research (MJFF) under the foundation's Rapid Response Innovation Awards program.”

“Other highlights from the March 21 JNCI”  This reference links to a non-governmental website
(Mar 20) EurekAlert! reports, “Eating a high-fat diet may lead to an increased risk of invasive breast cancer in postmenopausal women.”

“Parsi genes bottled for Rs 125-cr experiment”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 20) Hindustan Times reports, “A Rs 125-crore genetic research will be done on Parsis in India.”

“Severe mental retardation gene mutation identified”  This reference links to a non-governmental website
(Mar 20) EurekAlert! reports, “Researchers have identified a novel gene mutation that causes X-linked mental retardation for which there was no previously known molecular diagnosis, according to an article to be published electronically on Tuesday, March 20, 2007 in The American Journal of Human Genetics.”

“Small molecule derived from Rb2/p130 could act as cancer therapeutic”  This reference links to a non-governmental website
(Mar 20) EurekAlert! reports, “A small molecule derived from the spacer domain of the tumor-suppressor gene Rb2/p130 has demonstrated the ability to inhibit tumor growth in vivo and could be developed into an anti-cancer therapeutic, according to researchers at Temple University's Sbarro Institute for Cancer Research and Molecular Medicine.”

“Triplex assay used to assay duplex genomic DNA”  This reference links to a non-governmental website
(Mar 20) EurekAlert! reports, “Direct detection of base sequence in duplex nucleic acid has long been an unfulfilled objective.”

“Center for research on early detection, cure of ovarian cancer launches”  This reference links to a non-governmental website
(Mar 19) newswise reports, “The Abramson Cancer Center of the University of Pennsylvania, the University of Pennsylvania Health System and School of Medicine, and Penn’s Department of Obstetrics and Gynecology have announced today the establishment of the Center for Research on Early Detection and Cure of Ovarian Cancer.”

“'Gene therapy for foetuses' hope”  This reference links to a non-governmental website
(Mar 19) BBC News reports, “UK scientists believe in the future they will be curing babies in the womb of serious diseases with the use of gene therapy.”

“Genetic link to heavy substance abuse in teenagers”  This reference links to a non-governmental website
(Mar 19) Science Daily reports, “Family and community experiences play an important role in whether teenagers experiment with alcohol, cigarettes and marijuana, but genetic influences become more important for progression to heavy substance use, a team led by Cardiff University researchers has found.”

“Notorious cancer gene may work by destroying messenger”
(Mar 19) Research News reports, “A new study suggests how a notorious cancer gene may contribute to tumor growth.”

“Rare genetic disease found”  This reference links to a non-governmental website
(Mar 19) Chinadaily.com reports, “A young Shenzhen man was confirmed be suffering from a rare genetic disease which has resulted in the cross-positioning of his internal organs, Saturday's Daily Sunshine reported.”

“Scientist Develops New Mathematical Model To Study Disease Genetics And Evolution”  This reference links to a non-governmental website
(Mar 19) Science Daily reports, “USC College computational biologist Peter Calabrese has developed a new model to simulate the evolution of so-called recombination hotspots in the genome.”

“Video: The difference between fat and thin genes”
(Mar 18) Yahoo News reports, “Researchers have used a new technique to hunt for rare genetic quirks that explain why some people are extremely fat or very thin."

“Autism's roots: mix of chance and genetics”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 16) Baltimore Sun reports, “Researchers probing the roots of autism say they've found fresh evidence that the disorder, like cancer, could be a tough one to conquer.”

“In hispanic women, genetic variations linked to spontaneous preterm birth”  This reference links to a non-governmental website
(Mar 16) Medical News Today reports, “In Hispanic women, four gene variants are linked to spontaneous preterm birth, according to abstracts presented by researchers at Yale School of Medicine and Washington University at the Society for Gynecologic Investigation Conference in Reno, Nevada on March 16.”

“Genes plus parenting may promote shyness, anxiety”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 15) Reuters Health reports, “A mother whose child has a naturally fearful temperament may act less nurturing toward the child, triggering a vicious cycle of behavior that reinforces the child's fearfulness and shyness, researchers propose.”

“Dr. Kenneth Lyons Jones receives lifetime achievement award in genetics from March of
Dimes”
  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 15) Yahoo reports, “Kenneth Lyons Jones, M.D., the renowned pediatrician and birth defects researcher who was one of two doctors who identified fetal alcohol syndrome (FAS), will receive the 2007 March of Dimes/Colonel Harland Sanders Award for lifetime achievement in genetic sciences.”

“Tiny, spontaneous gene mutations may boost autism risk”  This reference links to a non-governmental website
(Mar 15) EurekAlert! Health reports, “Tiny gene mutations, each individually rare, pose more risk for autism than had been previously thought, suggests a study funded in part by the National Institute of Mental Health, a component of the National Institutes of Health.”

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Genomics in Scientific Literature
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The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals
Young EH, et al.
Int J Obes (Lond) 2007 Mar

The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: Design, Recruitment, and Initial Examination
Splansky GL, et al.
Am J Epidemiol 2007 Mar

PKDB: Polycystic Kidney Disease Mutation Database-a gene variant database for autosomal dominant polycystic kidney disease
Gout AM, et al.
Hum Mutat 2007 Mar

Genetics of sleep and sleep disorders
Kimura M & Winkelmann J
Cell Mol Life Sci 2007 Mar

China genetic counseling network (CGCN): a website on genetic counseling and genetic education
He M & Li W
Yi Chuan 2007 Mar;29(3):381-4

The role of gene-environment interaction in predicting adverse pregnancy outcome
Genc MR & Schantz-Dunn J
Best Pract Res Clin Obstet Gynaecol 2007 Mar

Genetics of Salt-sensitive Hypertension
Strazzullo P & Galletti F
Curr Hypertens Rep 2007 Mar;9(1):25-32

Addressing the obesity epidemic: a genomics perspective
Newell A, et al.
Prev Chronic Dis 2007 Apr;4(2):A31

A Two-stage approach to the correction of ascertainment bias in complex genetic studies involving variance components
Bowden J, et al.
Ann Hum Genet 2007 Mar;71(Pt 2):220-9

Most rare missense alleles are deleterious in humans: implications for complex disease and association studies
Kryukov GV, et al.
Am J Hum Genet 2007 Apr;80(4):727-39

Using a genetic algorithm to predict evaluation of acute coronary syndromes
Arslanian-Engoren C & Engoren M
Nurs Res 2007 Mar-2007 Apr;56(2):82-8

Medical radiation exposure and breast cancer risk: Findings from the Breast Cancer Family Registry
John EM, et al.
Int J Cancer 2007 Mar

Family History
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 In The News

“Screening catches young athletes’ heart trouble”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 15) MSNBC reports, “The number of cases of young athletes suddenly dying while playing their sport could be reduced with a 12-point screening process, the American Heart Association wants parents, coaches, and school administrators to know.”

 In The Scientific Literature

Missed opportunities: family history and behavioral risk factors in breast cancer risk assessment among a multiethnic group of women
Karliner LS, et al.
J Gen Intern Med 2007 Mar;22(3):308-14

Differences in risk factors for breast cancer molecular subtypes in a population-based study
Yang XR, et al.
Cancer Epidemiol Biomarkers Prev 2007 Mar;16(3):439-43

Screening patients with a family history of colorectal cancer
Fletcher RH, et al.
J Gen Intern Med 2007 Apr;22(4):508-13

Ascertainment Through Family History of Disease Often Decreases the Power of Family-based Association Studies
Ferreira MA, et al.
Behav Genet 2007 Mar

Genetic Testing
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 In The News

“Facing life with a lethal gene”  This reference links to a non-governmental website
(Mar 18) The New York Times reports, “The test, the counselor said, had come back positive.”

“Genetics of breast cancer”  This reference links to a non-governmental website (last accessed 2/2008)
(Mar 15) abc7chicago.com reports, “An experimental test is offering women the chance to find out if their genetic make-up puts them at an increase risk of developing breast cancer.”

 

 In The Scientific Literature

Diffusion of genetic testing in oncology: what criteria for regulation?
Eisinger F & Moatti JP
Med Sci (Paris) 2007 Mar;23(3):327-32

Pharmacogenetic studies of antidepressant response: how far from the clinic?
Perlis RH
Psychiatr Clin North Am 2007 Mar;30(1):125-38

Screening and genetic diagnosis of haemoglobinopathies
Old JM
Scand J Clin Lab Invest 2007;67(1):71-86

Genetic screening for cystic fibrosis: An overview of the science and the economics
Brice P, et al.
J Cyst Fibros 2007 Mar

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending March 21, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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microRNA in Human Disease and Development  This reference links to a non-governmental website
March 29-30, 2007 ~ Boston, MA

   
 

17th European Congress of Clinical Microbiology and Infectious Diseases  This reference links to a non-governmental website
March 31-April 3, 2007 ~ Munich, Germany

   
 

1st Course in Genetics of Rheumatic and Auto-inflammatory Diseases   This reference links to a non-governmental website
April 1-4, 2007 ~ Bertinoro di Romagna, Italy

   
New Listing EuroGP 2007- 10th European conference on Genetic Programming  This reference links to a non-governmental website
April 11-13, 2007 ~ Valencia, Spain
   
 

Microbial Genomes 2007  This reference links to a non-governmental website (last accessed 2/2008)
April 11-14, 2007 ~ Hinxton, UK

   
 

Epigenetics: Regulation of Chromatin Structure in Development and Disease  This reference links to a non-governmental website
April 11-16, 2007 ~ Breckenridge, CO


small triangle For a full listing of events, please visit the Upcoming Events page.
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Let's Go Surfing
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Genetic Information Nondiscrimination Act Hearing
The U.S. House of Representatives Committee on Energy and Commerce, Subcommittee on Health, held a hearing on H.R. 493, the “Genetic Information Nondiscrimination Act” on March 8, 2007.

Genome Canada  This reference links to a non-governmental website
Genome Canada is the primary funding and information resource relating to genomics and proteomics in Canada.

Personalized Medicine Coalition  This reference links to a non-governmental website
The Personalized Medicine Coalition (PMC) is an independent, non-profit group that works to advance the understanding and adoption of personalized medicine for the ultimate benefit of patients.  The PMC educates federal and state policymakers and private sector healthcare leaders about personalized medicine, helping them understand the science, the issues and what is needed for the positive evolution of personalized medicine.

 

 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: March 22, 2007 (archived document)
Content Source: National Office of Public Health Genomics