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Sponsored by: |
Sheba Medical Center |
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Information provided by: | Sheba Medical Center |
ClinicalTrials.gov Identifier: | NCT00423111 |
The purpose of this study is to determine whether there is a correlation between cognitive functions and volume of specific brain area measured in MRI of multiple sclerosis patients.
Condition |
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Multiple Sclerosis |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Convenience Sample, Retrospective/Prospective Study |
Estimated Enrollment: | 100 |
Study Start Date: | February 2007 |
Estimated Study Completion Date: | February 2009 |
Recent literature suggests that multiple sclerosis is accompanied by significant deficits in cognitive performance. The origin of these cognitive deficits is not known, since the severity of cognitive deficits was not found to be correlated with disease parameters such as duration, lesion load or disease intensity as measured on standard scales (e.g. EDSS). The research hypothesis we plan to test is that the individual intensity of cognitive deficits is correlated with degeneration of specific neuronal structures related to cognitive performance, such as the hippocampus and prefrontal cortex.
To test this hypothesis, we plan to perform volumetric measurements of such regions on MRI scans obtained from MS patients during the course of their clinical evaluation, and attempt to correlate those with the results of neuropsychological tests performed by the same subjects around the time of MRI scanning.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Yael Deri, BSc | 972 508273381 | yaelderi@gmail.com |
Contact: Anat Biegon, Ph.D | 972 52666177 | anat.biegon@sheba.health.gov.il |
Israel | |
Sheba Medical Center | Recruiting |
Ramat Gan, Israel, 52621 |
Principal Investigator: | Anat Achiron, MD Ph.D | Sheba Medical Center |
Study ID Numbers: | SHEBA-06-4487-AA-CTIL |
Study First Received: | January 15, 2007 |
Last Updated: | September 20, 2007 |
ClinicalTrials.gov Identifier: | NCT00423111 |
Health Authority: | Israel: Israeli Health Ministry Pharmaceutical Administration |
Multiple sclerosis Memory Cognitive deficits |
MRI Hippocampus Prefrontal cortex |
Autoimmune Diseases Multiple Sclerosis Demyelinating Diseases Demyelinating Autoimmune Diseases, CNS |
Demyelinating diseases Sclerosis Autoimmune Diseases of the Nervous System |
Pathologic Processes Immune System Diseases Nervous System Diseases |