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Sponsored by: |
Charite University, Berlin, Germany |
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Information provided by: | Charite University, Berlin, Germany |
ClinicalTrials.gov Identifier: | NCT00473603 |
The purpose of this study is to determine whether free fatty acids modify the androgen levels in healthy young women.
Condition | Intervention |
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Hyperandrogenism Glucocorticoid Metabolism |
Drug: lipid/heparin or saline/heparin infusion |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Placebo Control, Crossover Assignment, Efficacy Study |
Official Title: | Effect of Free Fatty Acids on Androgen Precursors in Vivo in Healthy Young Women |
Enrollment: | 13 |
Study Start Date: | December 2006 |
Study Completion Date: | May 2008 |
Primary Completion Date: | May 2008 (Final data collection date for primary outcome measure) |
Free fatty acids (FFA) are known to play an important role by inducing insulin resistance and metabolic disturbances in obesity and type 2 diabetes. In addition, FFAs seems to have a stimulatory effect on adrenal androgen precursors in men. However, the effect of FFAs on androgen precursors and androgens in women is yet unknown.
Therefore the effect of increased FFAs on adrenal androgens and androgen precursors should be investigated in a randomized controlled cross-over trial.
Ages Eligible for Study: | 18 Years to 30 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | 201-05 |
Study First Received: | May 14, 2007 |
Last Updated: | July 23, 2008 |
ClinicalTrials.gov Identifier: | NCT00473603 |
Health Authority: | Germany: Federal Institute for Drugs and Medical Devices |
androgens fatty acids |
Gonadal Disorders Endocrine System Diseases Hyperandrogenism Endocrinopathy |
Healthy Heparin Sex Differentiation Disorders Calcium heparin |
Fibrin Modulating Agents Anticoagulants Molecular Mechanisms of Pharmacological Action Therapeutic Uses |
Hematologic Agents Fibrinolytic Agents Cardiovascular Agents Pharmacologic Actions |