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Filled PDNs in PDF Format (file size 89k)

ABCDE - FGHIJ - KLMNO - PQRST - UVWXYZ

Substances	PDN Description	Status(1)
Aldrin/Dieldrin	Dose-response data in animals for intermediate(2)-duration oral exposure Bioavailability from soil Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers Exposure levels in children	Filled
Arsenic	Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers Bioavailability from soil	Filled
Asbestos	Potential candidate for subregistry of exposed persons Improved analytical methods for screening samples and determining the chemical structure of asbestos fibers. Also, techniques are needed to normalize studies in which different analytical methods were employed	Filled
Benzene	Epidemiologic studies on the health effects of benzene (Special emphasis end points include immunotoxicity) Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers	Filled
Beryllium	Analytical methods to determine environmental speciation Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers Exposure levels in children	Filled
Cadmium	Analytical methods for biological tissues and fluids and environmental media Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers Exposure levels in children	Filled
Carbon tetrachloride	Immunotoxicology battery of tests via oral exposure Half-life in soil Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers	Filled
Chlordane	Oral multigenerational studies to evaluate reproductive toxicity Exposure levels in humans (adults) living near hazardous waste sites and other populations potentially exposed to chlordane Exposure levels in children	Filled
Chlorinated dibenzo-p-dioxins (CDDs)	Exposure levels in humans (adults) living near hazardous waste sites Exposure levels in children	Filled
Chloroform	Dose-response data in animals for intermediate-duration oral exposure Epidemiologic studies on the health effects of chloroform (Special emphasis end points include cancer, neurotoxicity, reproductive and developmental toxicity, hepatotoxicity, and renal toxicity) Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers	Filled
Chromium	Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers	Filled
Cyanide	Evaluation of the environmental fate of cyanide in soil Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers	Filled
1,1-Dichloroethene	• Dose-response data in animals for acute(3)-duration exposure by the inhalation route Dose-response data in animals for chronic(4)-duration exposure by the inhalation route	Filled
DDT	Epidemiologic studies on the health effects of DDT, DDD, and DDE (Special emphasis end points include immunotoxicity, and reproductive and developmental toxicity) Bioavailability and bioaccumulation from soil Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers Exposure levels in children	Filled
Di(2-ethylhexyl) phthalate	Comparative toxicokinetic studies (Studies designed to examine how primates metabolize and distribute DEHP as compared with rodents via oral exposure) Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers Exposure levels in children	Filled
Di-n-butyl phthalate	Dose-response data in animals for acute- duration exposure via the oral route In vivo genotoxicity studies Environmental fate of di-n-butyl phthalate in environmental media Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers Exposure levels in children	Filled
Disulfoton	Immunotoxicology testing battery following oral exposure	Filled
Endrin/endrin aldehyde	Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers Exposure levels in children	Filled
Ethylbenzene	Dose-response data for acute-duration exposure by the inhalation ¬route Dose-response data for chronic-duration exposure by the inhalation route Multigeneration toxicity study examining reproductive end points and indicators of endocrine disruption following inhalation exposure Studies for comparative toxicokinetics Exposure levels in humans living near hazardous waste sites Exposure levels in children	Filled
Heptachlor/ heptachlor epoxide	Multigeneration reproductive toxicity studies via the oral route of exposure Prenatal developmental toxicity studies via the oral route of exposure Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers Exposure levels in children Dose-response animal data for acute- and intermediate-duration oral exposures, including immunopathology	Filled
Hexachloro-cyclohexane (α, β, γ, and δ)	Dose-response data for chronic-duration oral exposure Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers Exposure levels in children	Filled
Lead	Mechanistic studies on the neurotoxic effects of lead Analytical methods for tissue levels Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers Exposure levels in children	Filled
Manganese	Dose-response data for acute- and intermediate-duration oral exposures (the intermediate-duration study should include reproductive histopathology and an evaluation of immunologic parameters including manganese effects on plaque-forming cells (SRBC), surface markers (D4:D8 ratio), and delayed hypersensitivity reactions) Toxicokinetic studies on animals to investigate uptake and absorption, relative uptake of differing manganese compounds, metabolism of manganese, and interaction of manganese with other substances following oral exposure Epidemiological studies on the health effects of manganese (Special emphasis end points include neurologic, reproductive, developmental, immunologic, and cancer)	Filled
Mercury	Multigeneration reproductive toxicity study via oral exposure Dose-response data in animals for chronic-duration oral exposure Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers Exposure levels in children	Filled
Methoxychlor	Evaluate neurologic effects after long-term, low-level oral exposure	Filled
Methylene chloride	Dose-response data in animals for acute- and intermediate-duration oral exposure. The intermediate-duration study should include extended reproductive organ histopathology, neuropathology, and immunopathology Prenatal developmental toxicity study via the oral route Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers	Filled(5)
Nickel	Epidemiologic studies on the health effects of nickel (Special emphasis end points include reproductive toxicity) Prenatal developmental toxicity study via the oral route Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers	Filled
Pentachlorophenol	Exposure levels in humans (adults) living near hazardous waste sites Exposure levels in children through play activities near contaminated environmental media	Filled
Polychlorinated biphenyls (PCBs)	Epidemiologic studies on the health effects of PCBs (Special emphasis end points include immunotoxicity, gastrointestinal toxicity, liver toxicity, kidney toxicity, thyroid toxicity, and reproductive/developmental toxicity) Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers Exposure levels in children Chronic toxicity and oncogenicity via oral exposure(6) Aerobic PCB biodegradation in sediment(6) PCB congener analysis(6)	Filled
Polycyclic aromatic hydrocarbons (PAHs) (Includes 15 substances)	Dose-response data in animals for intermediate-duration oral exposures. The intermediate-duration study should include extended reproductive organ histopathology and immunopathology Prenatal developmental toxicity study via inhalation or oral exposure Mechanistic studies on PAHs, on how mixtures of PAHs can influence the ultimate activation of PAHs, and on how PAHs affect rapidly proliferating tissues Dose-response data in animals for acute- and intermediate-duration inhalation exposures. The intermediate-duration study should include extended reproductive organ histopathology and immunopathology Epidemiologic studies on the health effects of PAHs (Special emphasis end points include cancer, dermal, hemolymphatic,and hepatic toxicity) Exposure levels in humans (adults) living near hazardous waste sites and other populations, such as exposed workers Exposure levels in children	Filled
Selenium	Epidemiologic studies on the health effects of selenium (Special emphasis end points include cancer, reproductive and developmental toxicity, hepatotoxicity, and adverse skin effects) Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers	Filled
Tetrachloroethylene	Dose-response data in animals for acute-duration oral exposure, including neuropathology and demeanor, and immunopathology Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers	Filled
Toluene	Dose-response data in animals for acute- and intermediate-duration oral exposures. The intermediate-duration study should include an extended histopathologic evaluation of the immune system Comparative toxicokinetic studies (Characterization of absorption, distribution, and excretion via oral exposure) Mechanism of toluene-induced neurotoxicity Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers	Filled
Trichloroethylene	Dose-response data in animals for acute-duration oral exposure Epidemiologic studies on the health effects of trichloroethylene (Special emphasis end points include cancer, hepatotoxicity, renal toxicity, developmental toxicity, and neurotoxicity) Exposure levels in humans living near hazardous waste sites and other populations, such as exposed workers	Filled
Vinyl chloride	Dose-response data in animals for acute-duration inhalation exposure Multigeneration reproductive toxicity study via inhalation Prenatal developmental toxicity study via inhalation	Filled
Xylenes	Dose-response data for chronic-duration exposure by the oral route. This study should be done in conjunction with the neurotoxicology battery of tests Prenatal developmental toxicity study that includes neurodevelopmental end points following oral exposure Exposure levels in children	Filled
Zinc	Dose-response data in animals for acute- and intermediate-duration oral exposures. The intermediate-duration study should include an extended histopathologic evaluation of the immunologic and neurologic systems Multigeneration reproductive toxicity study via oral exposure	Filled

⁽¹⁾ Filled: A priority data need is filled:

• If it has been referred to one of the implementation mechanisms and research has been initiated, or
• If an updated ATSDR toxicological profile contains relevant new studies, or if other relevant, peer-reviewed, and publicly available new studies (not included in the toxicological profile) have been identified since the finalization of the priority data needs document; and it is generally agreed that a priority data need no longer exists.

Furthermore, in the event a priority data need is considered filled, it does not necessarily mean that the study has been completed and that ATSDR has accepted the data. It does, however, indicate that the agency no longer considers it a priority to initiate additional studies at this time.

⁽²⁾ Intermediate-duration exposure = 15 – 364 days.

⁽³⁾ Acute-duration exposure = 14 days or less.

⁽⁴⁾ Chronic-duration exposure = 365 days or more.

⁽⁵⁾ Neurotoxicity testing remains a priority data need in the EPA/ATSDR test rule.

⁽⁶⁾ Data need, not priority data need.

This page was updated on 09/19/2008
CDC INFO / cdcinfo@cdc.gov / 1-800-CDC-INFO