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Division of Vector-Borne Infectious Diseases Dengue: Clinical Manifestations and Epidemiology

Dengue Contents

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Dengue Fever Information for Travelers

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Dengue: Clinical and Public Health Aspects
Table of Contents
Return to menu | Intro | I | II | III | IV | V | VI | VII | VIII

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Introduction

  1. Title slide
  2. Authors
  3. Additional information
  4. Introduction
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I. Virus, Vector, and Transmission

  1. Title slide
  2. Dengue Virus
  3. Dengue Viruses
  4. Transmission of Dengue Virus by Aedes aegypti
  5. Replication and Transmission of Dengue Virus (Part 1)
  6. Replication and Transmission of Dengue Virus (Part 2)
  7. Aedes aegypti Mosquito
  8. Aedes aegypti
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II. Disease Surveillance and Control

  1. Title slide
  2. Proactive Surveillance: Goals and Objectives
  3. Proactive Surveillance in Puerto Rico
  4. Vector Control Methods: Chemical Control
  5. Vector Control Methods: Biological and Environmental Control
  6. Purpose of Control
  7. Programs to Minimize the Impact of Epidemics
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III. Clinical Manifestations of Dengue and Dengue Hemorrhagic Fever

  1. Title slide
  2. Dengue Clinical Syndromes
  3. Undifferentiated Fever
  4. Clinical Characteristics of Dengue Fever
  5. Signs and Symptoms of Encephalitis/Encephalopathy Associated with Acute Dengue Infection
  6. Hemorrhagic Manifestations of Dengue
  7. Clinical Case Definition for Dengue Hemorrhagic Fever
  8. Clinical Case Definition for Dengue Shock Syndrome
  9. Four Grades of DHF
  10. Danger Signs in Dengue Hemorrhagic Fever
  11. Warning Signs for Dengue Shock
  12. Signs and Symptoms in 57 Hospitalized Cases of DHF, Puerto Rico, 1990-1991
  13. Hemorrhagic Signs and Symptoms in 57 Hospitalized Cases of DHF, Puerto Rico, 1990-1991
  14. Hemorrhagic Signs and Symptoms in 57 Hospitalized Cases of DHF, Puerto Rico, 1990-1991
  15. Clinical Laboratory Analyses in 57 Hospitalized Cases of DHF, Puerto Rico, 1990-1991
  16. Profile of the Progression of Illness
  17. Unusual Presentations of Severe Dengue Fever
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IV. Epidemiology pdf icon(PDF 483KB/9 pages)

2005/2007

  1. Title slide
  2. World Distribution of Dengue, 2005
  3. Reported Cases of Dengue in the Americas 1980 - 2007
  4. Mean Annual Number of DHF Cases
  5. Dengue Hemorrhagic Fever in the Americas 1980 - 2007
  6. Presence of DEN-3 in the Americas 1994 - 2007
  7. Recent Dengue in the U.S.A
  8. Reasons for Dengue Expansion in the Americas
  9. Trouble Ahead
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V. Disease Pathogenesis

  1. Title slide
  2. Risk Factors Reported for DHF
  3. Risk Factors for DHF (continued)
  4. Increased Probability of DHF
  5. Hypothesis on Pathogenesis of DHF (Part 1)
  6. Homologous Antibodies Form Non-Infectious Complexes
  7. Hypothesis on Pathogenesis of DHF (Part 2)
  8. Heterologous Antibodies Form Infectious Complexes
  9. Hypothesis on Pathogenesis of DHF (Part 3)
  10. Heterologous Complexes Enter More Monocytes, Where Virus Replicates
  11. Hypothesis on Pathogenesis of DHF (Part 4)
  12. Viral Risk Factors for DHF Pathogenesis
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VI. Diagnosis

  1. Title slide
  2. General Recommendations for Medical Care
  3. Seasonal Trends in Dengue Incidence: Puerto Rico
  4. Travel History
  5. Differential Diagnosis of Dengue
  6. Clinical Evaluation in Dengue Fever
  7. Petechiae
  8. Pleural Effusion Index
  9. Tourniquet Test
  10. Positive Tourniquet Test
  11. Laboratory Tests in Dengue Fever
  12. Laboratory Methods for Dengue Diagnosis, CDC Dengue Branch
  13. Virus Isolation: Cell Culture
  14. Virus Isolation: Cell Culture
  15. Virus Isolation: Mosquito Inoculation
  16. Virus Isolation: Fluorescent Antibody Test
  17. ELISA Test for Serologic Diagnosis
  18. ELISA Plate
  19. Collection and Processing of Samples for Laboratory Diagnosis
  20. Procedures for Diagnosing a Suspected Dengue Fatality
  21. Temperature, Virus Positivity, and Anti-Dengue IgM, by Fever Day
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VII. Treatment

  1. Title slide
  2. Outpatient Triage
  3. Patient Follow-Up
  4. Treatment of Dengue Fever (Part 1)
  5. Mosquito Barriers
  6. Treatment of Dengue Fever (Part 2)
  7. Fluid for Moderate Dehydration (Intravenous)
  8. Rehydrating Patients Over 40 kg
  9. Treatment of Dengue Fever (Part 3)
  10. Indications for Hospital Discharge
  11. Common Misconceptions about Dengue Hemorrhagic Fever
  12. More Common Misconceptions about Dengue Hemorrhagic Fever
  13. Dengue Vaccine?
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VIII. Prevention

  1. Title slide
  2. Early Eradication Campaigns Succeeded
  3. Reinfestation by Aedes aegypti
  4. Hemispheric Eradication of Aedes aegypti No Longer Realistic
  5. Lessons for Future Dengue Prevention Programs
  6. Community Approaches
  7. Community Participation
  8. Skills Deficit
  9. Barriers and Motivation (Part 1)
  10. Barriers and Motivation (Part 2)
  11. Cues for Dengue Preventive Behaviors
  12. Cues: Feedback
  13. Cues: Presence of Adult Mosquitoes
  14. Cues: Water Shortages and Rationing
  15. Cues: Rainfall
  16. Examples of Community Programs: Puerto Rico
  17. The Challenge
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