Nominations to the Testing Program
Nominations Reviewed in 2005
- Acetyl-L-carnitine hydrochloride and Α-Lipoic acid
- Antimony trioxide
- Butylparaben
- 1,3-Dichloropropanol
- 2,5-Dimercapto-1,3,4-thiadiazole
- 3-Dimethylaminopropylamine
- Gum guggul extract
- Imidazolidinyl urea
- Permanent makeup inks
- Usnic acid and Usnea herb
- Vincamine
Substances for Which No Study is Recommended at this Time:
Note: A recommendation for "toxicological characterization" in this table includes studies for genotoxicity, subchronic toxicity, and chronic toxicity/carcinogenicity, as determined to be appropriate during the conceptualization and design of a research program to address toxicological data needs. Though other types of studies (e.g. metabolism and disposition, immunotoxicity, reproductive/developmental toxicity) may be conducted as part of a complete toxicological characterization, these types of studies are not listed unless they were specifically recommended.
For information, questions or comments, contact:
Dr. Scott A. Masten
Office of Chemical Nomination and Selection
Environmental Toxicology Program
National Institute of Environmental Health Sciences
111 T.W. Alexander Drive
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax)
[ Send Email ]
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
Acetyl-L-carnitine hydrochloride and Α-Lipoic acid [5080-50-2],[62-46-4] |
National Cancer Institute | Consumer exposure through increasing dietary supplement use; lack of adequate toxicological data | Subchronic toxicity studies (individual and combination studies) |
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
Antimony trioxide [1309-64-4] |
National Institute of Environmental Health Sciences | Significant human exposure in occupational settings and lack of adequate two-year exposure carcinogenicity studies |
|
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
Butylparaben [94-26-8] |
National Institute of Environmental Health Sciences | Widespread use in foods, cosmetics, and pharmaceuticals; potential reproductive toxicant; lack of adequate toxicological data | Toxicological characterization including reproductive toxicity studies |
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
1,3-Dichloropropanol [96-23-1] |
National Institute of Environmental Health Sciences | High production volume and use; occurrence in foods; reproductive toxicity and carcinogenicity demonstrated but not adequately characterized |
|
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
2,5-Dimercapto-1,3,4-thiadiazole [1072-71-5] |
Chemonics Industries, Inc. | Component of wildland fire retardant formulations; moderate production and industrial use; lack of adequate toxicological data |
|
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
3-Dimethylaminopropylamine [109-55-7] |
National Cancer Institute | Significant and increasing use in personal care products; widespread industrial use; lack of information on chronic toxicity; evidence of toxicity in exposed workers |
|
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
Gum guggul extract [No CAS No.] |
National Institute of Environmental Health Sciences | Consumer exposure through increasing dietary supplement use; demonstrated metabolic and hormonal effects; lack of adequate toxicological data | Toxicological characterization |
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
Imidazolidinyl urea [39236-46-9] |
National Cancer Institute | Widely used preservative in personal care products; mutagenic potential; lack of adequate carcinogenicity data |
|
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
Permanent makeup inks [No CAS No.] |
U.S. Food and Drug Administration | Rapidly growing practice in the United States; lack of adequate toxicological data; numerous human adverse event reports |
For representative Premier Products True Color pigments:
|
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
Usnic acid and Usnea herb [125-46-2],[No CAS No.] |
U.S. Food and Drug Administration | Widely used in dietary supplement and personal care products; lack of adequate toxicological data; numerous human adverse event reports |
|
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
Vincamine [1616-90-9] |
National Cancer Institute | Consumer exposure through dietary supplement use; suspicion of toxicity; lack of adequate toxicological data | Integrate into current NTP research program on QT interval prolongation |
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
Antimony trisulfide [1345-04-6] |
National Cancer Institute | Significant human exposure in occupational settings and suspicion of carcinogenicity | No additional studies at this time due to presumed lower workplace exposures relative to other antimony compounds |
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
4-Bromofluorobenzene [460-00-4] |
National Institute of Environmental Health Sciences | High production volume and use; lack of adequate toxicological data; suspicion of toxicity based on chemical structure | Defer pending review of anticipated submissions on exposure and toxicity information to the U.S. Environmental Protection Agency and possible sponsorship in the High Production Volume Challenge Program |
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
2,6-Diaminopyridine [141-86-6] |
National Cancer Institute | Moderate production and industrial use; lack of adequate toxicological data | Defer pending review of additional information on uses and potential exposure from hair dyes |
Substance [CAS No.] |
Nominated by | Rationale for Nomination | Study Recommendations* |
---|---|---|---|
Garcinia cambogia extract [No CAS No.] |
National Cancer Institute | Consumer exposure through increasing dietary supplement use; lack of adequate toxicological data | Defer pending further review of recently published studies |
Web page last updated on September 09, 2008