National Toxicology Program

Items received in response to the request for public comment in the May 5, 2005 Federal Register Notice (70 FR 86):

• Acetyl-L-carnatine hydrochloride & Α-Lipoic acid
• Antimony trioxide
• Antimony trisulfide
• 4-Bromofluorobenzene
• Butylparaben
• 2,6-Diaminopyridine
• 1,3-Dichloropropanol
• 2,5-Dimercapto- 1,3,4-thiadiazole
• 3-Dimethylamino- propylamine
• Garcinia cambogia extract
• Gum guggul extract
• Imidazolidinyl urea
• Permanent makeup inks
• Usnic acid & Usnea herb
• Vincamine

The NTP invites interested parties to submit written comments or supplementary information on the nominated substances and study recommendations. The NTP welcomes toxicology and carcinogenesis study information from completed, ongoing, or anticipated studies, as well as information on current U.S. production levels, use or consumption patterns, human exposure, environmental occurrence, or public health concerns for any of the nominated substances. The NTP is interested in identifying appropriate, novel, animal and non-animal experimental models for mechanistic-based research, including genetically modified rodents and higher-throughput in vitro test methods, and as such, solicits comments regarding the use of specific in vivo and in vitro experimental approaches to address questions relevant to the nominated substances and issues under consideration.

The NTP will not respond to submitted comments; however, all information received will be become part of the official record that the NTP considers in its ongoing review of these nominations. Persons submitting comments should include their name, affiliation, mailing address, phone, fax, e-mail address, and sponsoring organization (if any) with the submission. Written submissions will be made publicly available electronically on the NTP website as they are received.

Comments or information may be submitted at any time; however, to ensure adequate time for the NTP to provide any submissions to the NTP Board of Scientific Counselorsfor their review at the August 18, 2005 public meeting, comments should be submitted by July 11, 2005.

For information, questions or comments, contact:
Dr. Scott A. Masten
Office of Chemical Nomination and Selection
Environmental Toxicology Program
National Institute of Environmental Health Sciences

P.O. Box 12233, MD A3-07
111 T.W. Alexander Drive
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax)

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