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Sponsored by: |
Isala Klinieken |
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Information provided by: | Isala Klinieken |
ClinicalTrials.gov Identifier: | NCT00413543 |
This is a study to evaluate the effects of early pulmonary rehabilitation within 10 days after discharge from the hospital after a COPD exacerbation on exercise tolerance, exacerbations, re-admissions and the quality of life during 6 months.
Condition | Intervention |
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Chronic Obstructive Pulmonary Disease |
Behavioral: early pulmonary lung rehabilitation Other: control |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | Early Pulmonary Rehabilitation After Hospitalisation for Acute Exacerbation COPD |
Estimated Enrollment: | 100 |
Study Start Date: | October 2006 |
Estimated Study Completion Date: | October 2008 |
Arms | Assigned Interventions |
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A: Experimental
Early pulmonary rehabilitation
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Behavioral: early pulmonary lung rehabilitation
early pulmonary rehabilitation, 10 days after discharge
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B: No Intervention
Control
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Other: control
Control
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Study Design:
One hundred patients with an acute exacerbation of COPD admitted to the regular pulmonology department via the emergency room will be recruited after they have given written informed consent. Inclusion criteria are an age > 40 years or ≤ 80 years, at least 10 pack years of smoking history and COPD at least GOLD II. Each form of physical therapy is accepted outside pulmonary rehabilitation. Exclusion criteria include participation in a pulmonary rehabilitation program in the preceding year, comorbidity that can limit exercise training (for example: invalidating ischaemic heart disease, RA, malignancy and lung embolus), intolerance to prednisone, history of asthma, non-compliance, findings on chest radiography other than fitting with signs of COPD and a prior randomisation. During admission patients will receive standard exacerbation COPD treatment consisting of O2, combivent inhalation, antibiotics and prednisone. Exercise capacity is measured by a 6 minute walk test performed at discharge. The COPD GOLD classification is detected with a spirometry after completion of exacerbation therapy and before randomisation and discharge.
Both measurements are repeated after completion of the pulmonary rehabilitation program at 3 months. Quality of life is evaluated by the following questionnaires at discharge: St. George respiratory questionnaire (SGRQ), SF-36-scores (short form health survey) and clinical COPD questionnaire (CCQ). Before discharge, patients are randomised with a computer minimisation program for pulmonary rehabilitation or usual care with special attendance to age (< 70 years or ≥ 70 years), sex, length of hospital stay (< 7 days or ≥ 7 days), six minute walk test distance at discharge (< 100 or ≥ 100 meters) and predicted forced expiratory volume in one second (FEV1< or ≥ FEV1). Pulmonary rehabilitation will take place within ten days after discharge and shall be given by a multidisciplinary team (pulmonologist, respiratory nurse, physical therapist, dietician and a social worker). The program will last 2 hours weekly; 1 hour exercise training and one hour education during 8 weeks. All patients are followed up after discharge at 3 and 6 months. These questionnaires will be repeated after accomplishment of the pulmonary rehabilitation program at day 90 and day 180. Readmission rate will be also evaluated in this period.
Ages Eligible for Study: | 40 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Jan Willem Van den Berg, Dr. | 00 31 38 4244474 | j.w.k.van.den.berg@isala.nl |
Contact: Corinne Kloosterziel, Drs. | 00 31 38 42 7001 | c.kloosterziel@isala.nl |
Netherlands, Overijssel | |
Isala Klinieken | Recruiting |
Zwolle, Overijssel, Netherlands, 8011 JW | |
Contact: Jan Willem Van den Berg, Dr. 00 31 424 4474 j.w.k.van.den.berg@isala.nl | |
Contact: Corinne Kloosterziel, Drs. 00 31 424 7001 c.kloosterziel@isala.nl | |
Principal Investigator: Mehmet Parlak, Drs. |
Study Director: | Jan Willem Van den Berg, Dr. | Isala Klinieken |
Study ID Numbers: | NL11494.075.06, 06.0320 |
Study First Received: | December 18, 2006 |
Last Updated: | January 8, 2009 |
ClinicalTrials.gov Identifier: | NCT00413543 |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
COPD exacerbation pulmonary rehabilitation exercise tolerance |
exacerbations quality of life readmissions |
Lung Diseases, Obstructive Respiratory Tract Diseases Lung Diseases |
Respiration Disorders Quality of Life Pulmonary Disease, Chronic Obstructive |