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Sponsors and Collaborators: |
The Alfred National Health and Medical Research Council, Australia |
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Information provided by: | The Alfred |
ClinicalTrials.gov Identifier: | NCT00168207 |
The aim is to investigate the hypothesis that IL7-receptor polymorphisms contribute to the differential immune recovery of CD4 + T cells following HAART
Condition |
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HIV Infections |
Study Type: | Observational |
Study Design: | Cohort, Retrospective |
Official Title: | The Relationship of Single Nucleotide Polymorphisms in the Interleukin-7 Receptor-α Gene to CD4+ Immune Recovery in HIV Infected Patients Who Begin Antiretroviral Treatment With HAART |
Plasma, PBMC and DNA
Estimated Enrollment: | 210 |
Study Start Date: | May 2005 |
AIM: To examine the association between the four haplotypes of IL-7Rα gene and a cohort of HIV infected patients who have commenced HAART with varying CD4+ T lymphocyte responses.
METHODS: IL-7Rα gene SNPs and haplotypes will be measured by constructing DNA pools, and PCR amplification and DNA sequencing. IL-7Rα expression will be examined using constitutive expression of IL-7Rα, IL-7Rα gene expression, and inducible expression of IL7Rα.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
HIV infected patients on HAART
Inclusion Criteria:
Exclusion Criteria:
Contact: Sharon Lewin, Prof | 0061 3 9076 8491 | S.Lewin@alfred.org.au |
Australia, Victoria | |
The Alfred Hospital, Commercial Road | Recruiting |
Melbourne, Victoria, Australia, 3004 | |
Contact: Jennifer Hoy, A/Prof 0061 3 9276 6900 Jennifer.Hoy@med.monash.edu.au | |
Sub-Investigator: Reena Rajasuriar, MPharm | |
Principal Investigator: Sharon Lewin, Prof |
Study Director: | Jennifer Hoy, A/Prof | The Alfred Hospital |
Principal Investigator: | Sharon Lewin, Professor | Alfred Hospital, Melbourne, Vic 3004 |
Responsible Party: | The Alfred Hospital ( Professor Sharon Lewin ) |
Study ID Numbers: | 112/05 |
Study First Received: | September 9, 2005 |
Last Updated: | May 16, 2008 |
ClinicalTrials.gov Identifier: | NCT00168207 |
Health Authority: | Australia: National Health and Medical Research Council |
Treatment Experienced HIV |
Virus Diseases Sexually Transmitted Diseases, Viral HIV Infections Sexually Transmitted Diseases |
Acquired Immunodeficiency Syndrome Retroviridae Infections Immunologic Deficiency Syndromes |
RNA Virus Infections Slow Virus Diseases Immune System Diseases Lentivirus Infections Infection |