Drs. Emily Chew and John Paul San Giovanni, NEI, NIH - Mouse models of retinopathy of prematurity.
Dr. Chi-Chan Chao, NEI, NIH - Fat-1 mouse, omega-3 fatty acid status and experimentally induced uveitis.
Dr. Stanley Rapoport, NIA, NIH; Dr. John Umhau, LCTS, NIH; Drs. Richard Carson, Peter Herscovitz, PET Center, CC, NIH - PET imaging of human brain and heart using 11C-DHA.
Drs. Robert Sokol, John Hannigan, Janice Whitty, Fetal Alcohol Research Center, Wayne State University - This collaboration centers on the study of the involvement of essential fatty acids in mediating aspects of the Fetal Alcohol Syndrome. Maternal and newborn cord blood is obtained as well as alcohol history and nutrient intake; fatty acid compositional analysis is performed.
Dr. Manubu Nakamura, University of Illinois - Characterization of a delta-6 desaturase knock out mouse.
Dr. Greg Cole, UCLA - Effect of DHA on a mouse model of dementia.
Dr. Radha Ayyagari, University of Michigan - Fatty acid compositional changes and effects of diet on retinal pathology associated with ELOVL4 knock out mice.
Dr. Lois Smith, Harvard University - Effects of EPA and DHA on mouse models of retinopathy of prematurity.
Dr. Jan Palmblad, Karolinska Institute - Fatty acid composition of cerebrospinal fluid in patients with Alzheimer’s disease treated with DHA.
Drs. Kavita Shankar, Christopher DeGiorgio, UCLA - Analysis of essential fatty acids in plasma of intractable partial seizures.
Dr. Junji Hoshiba, Okuyama University, Japan - Collaborate on the development of artificial rearing methodology and application to the n-3 deficient rat model.
Dr. Lynn Goldman, Johns Hopkins University. Correlations of n-3 essential fatty acid status and mercury exposure with infant outcomes.
Drs. Ricardo Uauy, and Adolfo Llanos, INTA University of Chile, Santiago, Chile - Collaboration on the study of essential fatty acid metabolism in vivo in human infants in the first weeks of life.
Dr. Bruce Watkins, Purdue University - Collaborate on bone fatty acid compositional changes and mechanical properties during n-3 fatty acid depletion and repletion.
Drs. Jean Golding, Dieter Wolke, John M. Davis, ALSPAC Study Group, University of Bristol, UK - Adverse neurodevelopmental outcomes associated with the restriction of seafood consumption during pregnancy in compliance with the 2004 EPA/FDA advisory.
Dr. Marlene Freeman, University of Arizona - (K-23 mentor) - Omega-3 fatty acids in the treatment of depression in perinatal and postnatal periods.
Drs. Marc Schuckit, University of San Diego, Jean Golding, University of Bristol, UK, John M. Davis, University of Illinois - Prospective characterization of drinking behavior among 8,000 early adolescents.
Drs. Budens-Branchey and Branchey, VAMC, Brooklyn, NY - Treatment of mixed substance misuse subjects with omega-3 fats, a double blind placebo controlled trial.
Drs. Garland and Hallahan, University of Dublin, Ireland - John M. Davis, University of Illinois - Omega-3 essential fatty acid supplementation in patients with recurrent deliberate self harm: a double blind randomized controlled trial.
Drs. Mann, Sublette, Columbia University, NY- Low DHA status as a predictor of future suicide attempts.
Selected Recent Publications
Hibbeln JR, Ferguson TA, Blasbalg TL. Omega-3 fatty acid deficiencies in neurodevelopment, aggression and autonomic dysregulation: opportunities for Intervention. Intl Review Psychiatry. 18(2):107-118, 2006. PubMed [PDF]
Masood A, Stark KD, Salem N Jr.
A simplified and efficient method for the analysis of fatty acid methyl esters suitable for large clinical studies. J Lipid Res. 46(10):2299-2305, 2005. PubMed [PDF]
Lin YH, Salem N Jr. In vivo conversion of 18- and 20-C essential fatty acids in rats using the multiple simultaneous stable isotopes method. J Lipid Res. 46(9):1962-1973, 2005. PubMed [PDF]
Lim S-Y, Hoshiba J, Salem Jr N. An extraordinary degree of structural specificity is required in neural phospholipids for optimal brain function: n-6 docosapentaenoic acid substitution for docosahexaenoic acid leads to a loss in spatial task performance. J Neurochem. 95(3):848-857, 2005. PubMed [PDF]
Salem N Jr, Loewke J, Catalan JN, Majchrzak S, Moriguchi T. Incomplete replacement of docosahexaenoic acid by n-6 docosapentaenoic acid in the rat retina after an n-3 fatty acid deficient diet. Exp Eye Res. 81(6):655-863, 2005. PubMed [PDF]
Stark KD, Beblo S, Murthy M, Buda-Abela M, Janisse J, Rockett H, Whitty JE, Martier SS, Sokol RJ, Hannigan JH, Salem N Jr. Comparison of bloodstream fatty acid composition from African-American women at gestation, delivery and postpartum. J Lipid Res. 46(3):516-525, 2005. PubMed [PDF]
Lim SY, Hoshiba J, Moriguchi T, Salem N Jr. N-3 fatty acid deficiency induced by a modified artificial rearing method leads to poorer performance in spatial learning tasks. Ped Res. 58(4):741-748, 2005. PubMed [PDF]
Stark KD, Beblo S, Murthy M, Whitty JE, Buda-Abela M, Janisse J, Rockett H, Martier SS, Sokol RJ, Hannigan JH, Salem N Jr. Alcohol consumption in pregnant, black women is associated with decreased plasma and erythrocyte docosahexaenoic acid. Alcohol Clin Exp Res. 29(1):130-140, 2005. PubMed [PDF]
Lefkowitz W, Lim SY, Lin Y, Salem N Jr. Where does the developing brain obtain its docosahexaenoic acid? Relative contributions of dietary alpha-linolenic acid, docosahexaenoic acid, and body stores in the developing rat. Pediatr Res. 57(1):157-165, 2004. PubMed [PDF]
Pawlosky RJ, Salem N Jr. Development of alcoholic fatty liver and fibrosis in rhesus monkeys fed a low n-3 fatty acid diet. Alcohol Clin Exp Res. 28(10): 1569-1576, 2004. PubMed [PDF]
Moriguchi T, Lim S-Y, Greiner R, Lefkowitz W, Loewke J, Hoshiba J, Salem N Jr. Effects of an n-3 deficient diet on brain, retina and liver fatty acyl composition in artificially reared rats. J Lipid Res. 45:1437-1445, 2004. PubMed [PDF]
Hibbeln JR, Bissette G, Umhau JC, Georgo DT. Omega-3 status and cerebrospinal fluid corticotrophin releasing hormone in perpetrators of domestic violence. Biol Psychiatry. 56(11):895-897, 2004. PubMed [PDF]
Hibbeln JR, Nieminen LR, Lands WE. Increasing homicide rates and linoleic acid consumption among five Western countries, 1961-2000. Lipids. 39(12):1207-1213, 2004. PubMed [PDF]
Greiner RS, Catalan J and Salem Jr N. Docosapentaenoic acid does not completely replace docosahexaenoic acid in n-3 FA-deficient rats during early development. Lipids. 38(4):431-435, 2003. PubMed [PDF]
Pawlosky RJ, Hibbeln JR, Lin Y, Goodson S, Riggs P, Brown GL and Salem N Jr. Effects of beef- and fish-based diets on the kinetics of n-3 fatty acid metabolism in human subjects. Am J Clin Nutr. 77: 565-572, 2003. PubMed [PDF]
Moriguchi T, N Salem Jr. Recovery of brain docosahexaenoate leads to recovery of spatial task performance. J Neurochem. 87(2):297-309, 2003. PubMed [PDF]
Hibbeln JR, Makino KK, Martin CE, Dickerson F, Boronow J, Fenton WS. Smoking, gender, and dietary influences on erythrocyte essential fatty acid composition among patients with schizophrenia or schizoaffective disorder. Biol Psychiatry. 53(5):431-441, 2003. PubMed [PDF]
Buydens-Branchey J, Branchey M, McMakin D, Hibbeln JR. Polyunsaturated fatty acids and relapse vulnerability in cocaine addicts. Psychiatry Research. 120(1):29-35, 2003. PubMed [PDF]
Budens-Branchey J, Branchey M, McMakin D, Hibbeln JR. Polyunsaturated fatty acid status and aggression in cocaine addicts. Drug Alcohol Dependence. 71(3):319-323, 2003. PubMed [PDF]
Lin Y, Salem N Jr. A technique for the in vivo study of multiple stable isotope-labeled essential fatty acids. Prostaglandins Leukotrienes Essential Fatty Acids. 67(2-3):141-146, 2002. PubMed
Catalan J, Moriguchi T, Slotnick B, Murthy M, Greiner RS, Salem N Jr. Cognitive deficits in docosahexaenoic acid-deficient rats. Behavioral Neurosci. 116(6):1022-1031, 2002. PubMed [PDF]
Ahmad A, Moriguchi T, Salem N. Decrease in neuron size in docosahexaenoic acid-deficient brain. Ped Neurology. 26(3):210-218, 2002. PubMed [PDF]
Hibbeln JR. Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. J Affect Disord. 69(1-3):15-29, 2002. PubMed [PDF]
Champoux M, Hibbeln JR, Shannon C, Majchrzak S, Suomi SJ, Salem N Jr, Higley JD. Fatty acid formula supplementation and neuromotor development in rhesus monkey neonates. Pediatr Res. 51(3):273-281, 2002. PubMed [PDF]
Pawlosky RJ, Bacher J, Salem N Jr. Ethanol consumption alters electroretinograms and depletes neural tissues of docosahexaenoic acid in rhesus monkeys: nutritional consequences of a low n-3 fatty acid diet. Alcohol Clin Exp Res. 25(12):1758-1765, 2001. PubMed [PDF]
Pawlosky RJ, Hibbeln JR, Novotny JA, Salem N Jr. Physiological compartmental analysis of alpha–linolenic acid metabolism in adult humans. J Lipid Res. 42(8):1257-1265, 2001. PubMed [PDF]
Salem N Jr, Litman B, Kim HY, Gawrisch K. Mechanisms of action of docosahexaenoic acid in the nervous system. Lipids. 36(9):945-59, 2001. PubMed [PDF]
Moriguchi T, Loewke J, Garrison M, Catalan JN, Salem N Jr. Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver and serum. J Lipid Res. 42(3):419-427, 2001. PubMed [PDF]
Salem N Jr, Moriguchi T, Greiner RS, McBride K, Ahmad A, Catalan JN, Slotnick B. Alterations in brain function after loss of docosahexaenoate due to dietary restriction of n-3 fatty acids. J Molecular Neurosci. 16:299-307, 2001. PubMed [PDF]
Greiner RS, Moriguchi T, Slotnick BM, Hutton A, and Salem N. Olfactory discrimination deficits in n-3 fatty acid deficient rats. Physiology & Behavior. 72:379-385, 2001. PubMed
Hibbeln JR. Seafood consumption and homicide mortality. A cross-national analysis. World Rev Nutr Diet. 88:41-46, 2001. PubMed [PDF]
Tanskanen A, Hibbeln JR, Tuoileheto J, Uutela A, Haukkala A, Viinamaki H, Lehtonen J, Vartainen E. Fish consumption and depressive symptoms in the general population in Finland. Psychiatr Serv. 52(4):529-531, 2001. PubMed
Tanskanen A, Hibbeln JR, Hintikka J, Haatainen K, Honkalampi K, Viinamäki H. Fish consumption, depression, and suicidality in a general population. Arch Gen Psychiatry. 58(5):512-513, 2001. PubMed [PDF]
Fenton WS, Dickerson F, Boronow J, Hibbeln JR, Knable M. A placebo-controlled trial of omega-3 fatty acid (ethyl-EPA) supplementation for residual symptoms and cognitive impairment in schizophrenia. Am J Psychiatry. 158(12):2071-2074, 2001. PubMed
Moriguchi T, Greiner RS, Salem N Jr. Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. J Neurochem. 75(6):2563-2573, 2000. PubMed [PDF]
Uauy R, Mena P, Wegher B, Nieto S, Salem N Jr. Long chain polyunsaturated fatty acid formation in neonates: effect of gestational age and intrauterine growth. Pediatr Res. 47(1):127-135, 2000. PubMed
Hibbeln JR, Umhau JC, George DT, Shoaf SE, Regan P, Linnoila M, Salem N Jr. Plasma total cholesterol concentrations do not predict cerebrospinal fluid neurotransmitter metabolites: implications for the biophysical role of highly unsaturated fatty acids. Am J Clin Nutr. 71(1 Suppl):331S-338S, 2000. PubMed
Pawlosky RJ, Salem N Jr. Alcohol consumption in rhesus monkeys depletes tissues of polyunsaturated fatty acids and alters essential fatty acid metabolism. Alcohol Clin Exper Res. 23(2):311-317, 1999. PubMed
Hibbeln JR, Umhau JC, Linnoila M, George DT, Ragan PW, Shoaf SE, Vaughan MR, Rawlings R, Salem Jr N. A replication study of violent and nonviolent subjects: cerebrospinal fluid metabolites of serotonin and dopamine are predicted by plasma essential fatty acids. Biol Psych. 44(4):243-249, 1998. PubMed
Olsson NU, Shoaf SE and Salem N Jr. The effect of dietary polyunsaturated fatty acids and alcohol on neurotransmitter levels in rat brain. Nutritional Neurosci. 1:133-140, 1998.
Hibbeln JR. Fish consumption and major depression. Lancet. 351(9110):1213, 1998. PubMed
Salem N Jr, Wegher B, Mena P, Uauy R. Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. Proc Natl Acad Sci USA. 93(1):49-54, 1996. PubMed [PDF]
Hibbeln JR and Salem N Jr. Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy. Am J Clinical Nutr. 62(1):1-9, 1995. PubMed [PDF]