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Drug Table Supplement Contents
SECTION C Medications for the Treatment of Dyslipidemia
Category |
Generic Name |
Brand Name |
Minimum Daily Dose |
Maximum Daily Dose |
Special Considerations for class of drugs |
HMG-Coa = 3-hydroxy-3-methylglutaryl coenzyme A LDL = low-density lipoprotein HDL = high-density lipoprotein
TC = total cholesterol TG = plasma triglycerides generic = generic drug manufacturers |
HMG-CoA reductase
inhibitors (statins) |
atorvastatin |
Lipitor™ |
10 mg QD |
80 mg in divided doses |
Main action: Lowers LDL (“bad”) cholesterol.
Also lowers TG and modestly raises HDL.
Have blood tests for liver enzyme concentrations.
Notify physician if muscle aches or weakness develops.
Use caution if combined with fibric acid derivatives due to the increased risk of rhabdomyolysis. |
| fluvastatin |
Lescol™ |
20 mg QD |
80 mg in divided doses |
| fluvastatin |
Lescol XL™ |
80 mg QD |
80 mg in divided doses |
| lovastatin |
Mevacor™ |
10 mg QD |
80 mg in divided doses |
| lovastatin (extended-release) |
Altocor™ |
20 mg QD |
60 mg QD |
| pravastatin |
Pravachol™ |
10 mg QD |
80 mg QD |
| rosuvastatin |
Crestor™ |
5 mg QD |
40 mg QD |
| simvastatin |
Zocor™ |
5 mg QD |
80 mg in divided doses |
Cholesterol absorption
inhibitors |
ezetimibe |
Zetia™ |
10 mg QD |
10 mg QD |
Main action: Lowers LDL cholesterol; inhibits absorption of
cholesterol.
If used with a statin, take together.
If used with bile acid sequestrant, ezetimibe should be taken
2 hr before or 4 hr after bile acid sequestrant. |
| Nicotinic acid (niacin) |
nicotinic acid
(extended release) |
Niaspan™ |
50–100 mg QD |
2,000 mg QD |
Main action: Lowers LDL cholesterol increases HDL (“good”)
cholesterol, lowers triglycerides.
Take with food.
May cause flushing.
May increase blood glucose levels.
Have blood tests for liver enzyme concentrations.
Long-acting forms may be more likely to cause liver malfunction. |
| nicotinic acid |
|
250 mg/day QD |
Titrated up to 1500mg
therapeutic dose in
3 divided doses.
Maximum dose= 3000mg |
| Lipid combinations |
lovastatin-niacin |
Advicor™ |
20 mg/500 mg QD |
40 mg/2,000 mg QD |
Main Action: Reduces LDL, TC , and TG and increases HDL
due to the individual actions of niacin and lovastatin. |
| simvastatin-ezetimibe |
Vytorin™ |
10 mg/10 mg QD |
80 mg/10 mg QD |
Main Action: Reduces LDL cholesterol. |
| Amlodipine+atorvastatin |
Caduet™ |
2.5mg/10mg QD |
10 mg/80 mg QD |
Blood Pressure medication (Calcium channel blocker)
(see Blood pressure med chart)+lipid (statin)
medication. Same comments as individual |
| Fibric acid derivatives |
fenofibrate |
Tricor™ |
48 mg QD |
145 mg QD |
Main action: Lowers triglycerides, increases HDL cholesterol.
Perform blood tests for liver enzyme concentrations.
Adjust dose based on age and renal impairment.
Notify physician if muscle aches or weakness develops. |
| fenofibrate |
Lofibra™ |
67 mg QD |
200 mg QD |
| fenofibrate |
Triglide™ |
50 mg QD |
160 mg QD |
| fenofibrate |
Antara™ |
43 mg QD |
130 mg QD |
| gemfibrozil |
Lopid™ |
1,200 mg BID |
1,200 mg BID |
| Bile acid sequestrants |
cholestyramine |
LoCHOLEST™ |
4 g QD |
24 g in divided doses |
Main action: Lowers LDL cholesterol.
May cause constipation and stomach upset.
May need to be taken at a different time than other medications to avoid drug interactions.
May increase triglycerides blood concentrations.
Can be combined with other agents such as statins. |
| cholestyramine light |
LoCHOLEST light™ |
4 g QD |
24 g in divided doses |
| cholestyramine |
Questran™ |
4 g QD |
24 g in divided doses |
| cholestyramine light |
Questran light™ |
4 g QD |
24 g in divided doses |
| cholestyramine |
Prevalite™ |
4 g QD |
24 g in divided doses |
| cholestipol |
Colestid™ |
2g QD or BID |
6g QD or BID |
| colesevelam |
Welchol™ |
1,875 mg (3 tablets) QD |
4,375 mg (7 tabs) QD
or BID |
NDEP-54-S
March 2007
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National Diabetes Education Program (NDEP) http://ndep.nih.gov
NIDDK, National Institutes of Health, Bethesda, MD
A Joint Initiative of the National Institutes of Health and the
Centers for Disease Control and Prevention |
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Includes information about managing the ABCs of Diabetes. Also features information for people with diabetes who are eligible for Medicare benefits.
Learn how to prevent or delay type 2 diabetes through small steps.
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