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Resistive Exercise for Arthritic Cartilage Health (REACH)
This study is ongoing, but not recruiting participants.
Sponsored by: University of Sydney
Information provided by: University of Sydney
ClinicalTrials.gov Identifier: NCT00465660
  Purpose

Female subjects over the age of 40 will be recruited and randomised into a progressive resistance training (PRT) or sham-exercise group. The PRT group will train at 80% of their peak strength, using Keiser pneumatic resistance machines, and progress approximately 3% per session. Strength will be re-assessed fortnightly. Exercises will target muscles around the hip and knee. The sham-exercise group will train on the same equipment as the PRT group except hip adduction, but without added resistance or progression. Both groups will train 3 days per week for roughly 45 minutes for 6 months.

It is hypothesised that high intensity PRT will decelerate the tibial and femoral cartilage degeneration in the knee affected most by OA.

Primary Outcome:

Articular cartilage morphology following 6 months high intensity progressive resistance training

Secondary Outcomes:

Muscle and fat cross-sectional area (CSA) (pre and post) Muscle strength, power, endurance, and contraction velocity (pre, 3 months, & post) Medications (pre, 3 months, & post) Body composition (pre, 3 months, & post) Balance; Physical function (pre, 3 months, & post) Questionnaires (pre, 3 months, & post)

  • Habitual exercise (PASE) -WOMAC index (pain, stiffness and functional ability)
  • Depressive symptoms (Depression Scale) -Quality of life (SF36)
  • Confidence performing physical activity (Ewart) -Demographics

Condition Intervention Phase
Osteoarthritis
 Behavioral: Progressive resistance training
 Phase II

MedlinePlus related topics: Depression Exercise and Physical Fitness Osteoarthritis
U.S. FDA Resources
Study Type: Interventional
Study Design: Treatment, Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study
Official Title: The Effect of 6 Month High Intensity Progressive Resistance Training on Knee Articular Cartilage Morphology in Female Osteoarthritic Patients

Further study details as provided by University of Sydney:

Primary Outcome Measures:
  • Articular cartilage morphology following 6 months high intensity progressive resistance training

Secondary Outcome Measures:
  • Muscle and fat cross-sectional area (CSA) (pre and post)
  • Muscle strength, power, endurance, and contraction velocity (pre, 3 months, & post)
  • Medications (pre, 3 months, & post)
  • Body composition (pre, 3 months, & post)
  • Balance; Physical function (pre, 3 months, & post)
  • Questionnaires (pre, 3 months, & post):
  • Habitual exercise (PASE)
  • WOMAC index (pain, stiffness and functional ability)
  • Depressive symptoms (Depression Scale)
  • Quality of life (SF36)
  • Confidence performing physical activity (Ewart)
  • Demographics

Estimated Enrollment: 60
Study Start Date: April 2005
Estimated Study Completion Date: July 2009
  Eligibility

Ages Eligible for Study:   40 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Female
  • Aged over 40 years old
  • Primary Osteoarthritis in at least one knee using standard criteria of the American College of Rheumatology (ACR) criteria for classification of clinical osteoarthritis
  • Ambulatory without human assistance
  • Willingness to be randomised to experiential or control group
  • Ability to attend scheduled exercise and testing sessions

Exclusion Criteria:

  • Regular exercise of any kind over the past 3 months (>1dpw).
  • Secondary osteoarthritis (traumatic or post-surgical), rheumatic disease, gouty or septic arthritis, Paget's disease, pseudogout, major congenital abnormalities, hemochromatosis, Wilson's disease and other rare forms of arthritis
  • Joint injury, injection or surgery within the past 6 months or knee joint replacement
  • Contraindications to MRI/Exercise
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00465660

Locations
Australia, New South Wales
University of Sydney
Sydney, New South Wales, Australia, 2140
Sponsors and Collaborators
University of Sydney
Investigators
Principal Investigator: Benedicte Vanwanseele, PhD University of Sydney
  More Information

Study ID Numbers: ACTRN012605000116628
Study First Received: April 24, 2007
Last Updated: April 24, 2007
ClinicalTrials.gov Identifier: NCT00465660  
Health Authority: Australia: Human Research Ethics Committee

Keywords provided by University of Sydney:
Osteoarthritis
Cartilage
Exercise
Progressive Resistance Training

Study placed in the following topic categories:
Musculoskeletal Diseases
Osteoarthritis
Joint Diseases
Arthritis
Rheumatic Diseases

ClinicalTrials.gov processed this record on January 16, 2009



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