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Sponsored by: |
Universitaire Ziekenhuizen Leuven |
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Information provided by: | Universitaire Ziekenhuizen Leuven |
ClinicalTrials.gov Identifier: | NCT00433264 |
Despite major advances in the treatment of chronic kidney disease, the age and sex matched mortality far exceeds that of the normal population. As in the normal population, the majority of deaths are related to cardiovascular disease. Mounting data point to the lethal synergy between chronic kidney disease and cardiovascular disease. This relation is present from early stages of chronic kidney disease on.
Several uremic toxins have been demonstrated to play an important role in kidney disease related endothelial dysfunction. In peritoneal dialysis patients, data on the relation between uremic toxins, endothelial dysfunction and microparticles are lacking.
We hypothesise that endothelial dysfunction and uremic toxins are interrelated in peritoneal dialysis patients
Condition | Intervention | Phase |
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Chronic Kidney Disease |
Procedure: peritoneal dialysis |
Phase 0 |
Study Type: | Observational |
Study Design: | Case-Only, Prospective |
Official Title: | The Interrelation of the Vasculature, Endothelium, Bone Metabolism and Uremic Toxins in Peritoneal Dialysis |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Tertiary referral center university hospital
Inclusion Criteria:
Exclusion Criteria:
Contact: Björn Meijers, MD | +32 16 342352 | bjorn.meijers@uz.kuleuven.ac.be |
Contact: Kathleen Claes, MD | + 32 16 344580 | kathleen.claes@uz.kuleuven.ac.be |
Belgium, Vlaams-Brabant | |
Universitaire Ziekenhuizen Leuven | Recruiting |
Leuven, Vlaams-Brabant, Belgium, 3000 | |
Contact: Bjorn Meijers, MD +32 16 342352 bjorn.meijers@uz.kuleuven.ac.be | |
Contact: Kathleen Claes, MD +32 16 344580 kathleen.claes@uz.kuleuven.ac.be | |
Principal Investigator: Bjorn Meijers, MD | |
Principal Investigator: Kathleen Claes, MD |
Principal Investigator: | Bjorn Meijers, MD | UZ Leuven |
Principal Investigator: | Kathleen Claes, MD | UZ Leuven |
Study Director: | Pieter Evenepoel, MD, PhD | UZ Leuven |
Responsible Party: | University Hospitals Leuven ( Pieter Evenepoel ) |
Study ID Numbers: | ML3645 |
Study First Received: | February 7, 2007 |
Last Updated: | March 12, 2008 |
ClinicalTrials.gov Identifier: | NCT00433264 |
Health Authority: | Belgium: Institutional Review Board |
peritoneal dialysis endothelium endothelial dysfunction |
Renal Insufficiency Urologic Diseases Renal Insufficiency, Chronic |
Kidney Failure, Chronic Kidney Diseases Kidney Failure |