The Interrelation of the Vasculature, Endothelium, Bone Metabolism and Uremic Toxins in Peritoneal Dialysis - Tabular View

This Tabular View shows the required WHO registration data elements as marked by ^†

Tracking Information

First Received Date ^†

February 7, 2007

Last Updated Date

March 4, 2009

Start Date ^†

February 2007

Current Primary Outcome Measures ^†

Original Primary Outcome Measures ^†

Change History

Complete list of historical versions of study NCT00433264 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^†

Original Secondary Outcome Measures ^†

Descriptive Information

Brief Title ^†

The Interrelation of the Vasculature, Endothelium, Bone Metabolism and Uremic Toxins in Peritoneal Dialysis

Official Title ^†

The Interrelation of the Vasculature, Endothelium, Bone Metabolism and Uremic Toxins in Peritoneal Dialysis

Brief Summary

Despite major advances in the treatment of chronic kidney disease, the age and sex matched mortality far exceeds that of the normal population. As in the normal population, the majority of deaths are related to cardiovascular disease. Mounting data point to the lethal synergy between chronic kidney disease and cardiovascular disease. This relation is present from early stages of chronic kidney disease on.

Several uremic toxins have been demonstrated to play an important role in kidney disease related endothelial dysfunction. In peritoneal dialysis patients, data on the relation between uremic toxins, endothelial dysfunction and microparticles are lacking.

The investigators hypothesize that endothelial dysfunction and uremic toxins are interrelated in peritoneal dialysis patients

Detailed Description

Study Phase

Phase 0

Study Type ^†

Observational

Study Design ^†

Case-Only, Prospective

Condition ^†

Chronic Kidney Disease

Intervention ^†

Procedure: peritoneal dialysis

Study Arms / Comparison Groups

Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status ^†

Completed

Enrollment ^†

Completion Date

December 2008

Primary Completion Date

December 2008 (final data collection date for primary outcome measure)

Eligibility Criteria ^†

Inclusion Criteria:

age > 18
Maintenance peritoneal dialysis

Exclusion Criteria:

No informed consent
Peritonitis

Gender

Both

Ages

18 Years and older

Accepts Healthy Volunteers

Contacts ^††

Location Countries ^†

Belgium

Expanded Access Status

Administrative Information

NCT ID ^†

NCT00433264

Responsible Party

Pieter Evenepoel, University Hospitals Leuven

Secondary IDs ^††

Study Sponsor ^†

Universitaire Ziekenhuizen Leuven

Collaborators ^††

Investigators ^†

Principal Investigator:	Bjorn Meijers, MD	UZ Leuven
Principal Investigator:	Kathleen Claes, MD	UZ Leuven
Study Director:	Pieter Evenepoel, MD, PhD	UZ Leuven

Information Provided By

Universitaire Ziekenhuizen Leuven

Verification Date

March 2009

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.