Our Science – Rausch Website

Jason W. Rausch, Ph.D.

Selected Publications

1) Rausch JW, Le Grice SF.
Exploiting structurally diverse nucleoside analogs as probes of reverse transcription complexes.
Curr. HIV Res. 5: 11-22, 2007. [Journal]

2) Rausch JW, Le Grice SF.
Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis.
Nucleic Acids Res. 35: 256-68, 2007. [Journal]

3) Rausch JW, Le Grice SF.
'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus.
Int. J. Biochem. Cell Biol. 36: 1752-66, 2004. [Journal]

4) Dash C, Rausch JW, Le Grice SF.
Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3' polypurine tract.
Nucleic Acids Res. 32: 1539-47, 2004. [Journal]

5) Rausch JW, Qu J, Yi-Brunozzi HY, Kool ET, Le Grice SF.
Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection.
Proc. Natl. Acad. Sci. U.S.A. 100: 11279-84, 2003. [Journal]

6) Rausch JW, Lener D, Miller JT, Julias JG, Hughes SH, Le Grice SF.
Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity.
Biochemistry. 41: 4856-65, 2002. [Journal]

7) Cristofaro JV, Rausch JW, Le Grice SF, DeStefano JJ.
Mutations in the ribonuclease H active site of HIV-RT reveal a role for this site in stabilizing enzyme-primer-template binding.
Biochemistry. 41: 10968-75, 2002. [Journal]

8) Miller JT, Rausch JW, Le Grice SF.
Evaluation of retroviral ribonuclease H activity.
Methods Mol. Biol. 160: 335-54, 2001. [Journal]

9) Gorshkova II, Rausch JW, Le Grice SF, Crouch RJ.
HIV-1 reverse transcriptase interaction with model RNA-DNA duplexes.
Anal. Biochem. 291: 198-206, 2001. [Journal]

10) Rausch JW, Grice MK, Henrietta M, Miller JT, Le Grice SF.
Interaction of p55 reverse transcriptase from the Saccharomyces cerevisiae retrotransposon Ty3 with conformationally distinct nucleic acid duplexes.
J. Biol. Chem. 275: 13879-87, 2000. [Journal]

11) Cowan JA, Ohyama T, Howard K, Rausch JW, Cowan SM, Le Grice SF.
Metal-ion stoichiometry of the HIV-1 RT ribonuclease H domain: evidence for two mutually exclusive sites leads to new mechanistic insights on metal-mediated hydrolysis in nucleic acid biochemistry.
J. Biol. Inorg. Chem. 5: 67-74, 2000. [Journal]

12) Rausch JW, Sathyanarayana BK, Bona MK, Le Grice SF.
Probing contacts between the ribonuclease H domain of HIV-1 reverse transcriptase and nucleic acid by site-specific photocross-linking.
J. Biol. Chem. 275: 16015-22, 2000. [Journal]

13) Stetor SR, Rausch JW, Guo MJ, Burnham JP, Boone LR, Waring MJ, Le Grice SF.
Characterization of (+) strand initiation and termination sequences located at the center of the equine infectious anemia virus genome.
Biochemistry. 38: 3656-67, 1999. [Journal]

14) Rausch JW, Le Grice SF.
Substituting a conserved residue of the ribonuclease H domain alters substrate hydrolysis by retroviral reverse transcriptase.
J. Biol. Chem. 272: 8602-10, 1997. [Journal]

15) Arts EJ, Stetor SR, Li X, Rausch JW, Howard KJ, Ehresmann B, North TW, Wöhrl BM, Goody RS, Wainberg MA, Grice SF.
Initiation of (-) strand DNA synthesis from tRNA(3Lys) on lentiviral RNAs: implications of specific HIV-1 RNA-tRNA(3Lys) interactions inhibiting primer utilization by retroviral reverse transcriptases.
Proc. Natl. Acad. Sci. U.S.A. 93: 10063-8, 1996. [Journal]

16) Rausch JW, Arts EJ, Wöhrl BM, Le Grice SF.
Involvement of C-terminal structural elements of equine infectious anemia virus reverse transcriptase in DNA polymerase and ribonuclease H activities.
J. Mol. Biol. 257: 500-11, 1996. [Journal]

17) Cirino NM, Cameron CE, Smith JS, Rausch JW, Roth MJ, Benkovic SJ, Le Grice SF.
Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase.
Biochemistry. 34: 9936-43, 1995. [Journal]

This page was last updated on 6/12/2007.