This plan extends the HIV Prevention Strategic Plan Through 2005 (2001 Plan) published by the Centers for Disease Control and Prevention (CDC) in January 2001. The short-term goal, milestones, and accompanying objectives are based on general and specific recommendations from the CDC and HRSA Advisory Committee on HIV and STD Prevention and Treatment (CHAC), formerly known as the Advisory Committee for HIV and STD Prevention. The HIV Prevention Strategic Plan: Extended Through 2010 ( Extended Plan), which will serve as CDC’s strategic guide for HIV prevention through 2010, includes a short-term goal of reducing new HIV infections by 5 percent per year or at least 10 percent by the end of 2010. To achieve this goal, the Extended Plan includes an expanded set of objectives and performance indicators that make priorities more explicit and ensure that key issues are effectively addressed. Twelve new objectives have been added, 20 existing objectives have been modified, and one objective was deleted (42 objectives total, compared to 27 in the 2001 Plan). The Extended Plan also incorporates 17 additional performance indicators (25 total, compared to 11 previously).