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Early detection of iron overload requires an understanding of the
complex relationships between prevalence of iron overload, HFE gene
mutations and penetrance of the disease.
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| "An important challenge for genomics and public
health in the next decade is to develop the road map for
integrating genetics into disease prevention and health
promotion programs. Ultimately people die from diseases and
not from genes. We need information, information, and more
information! We need to collect, analyze, and disseminate
population-level information on the prevalence of gene
variants, disease burden, and gene-environment interaction.
We also need to evaluate genetic tests and the utility of
genetic information. The ultimate challenge is to determine
the benefits of using genetic information to target
interventions that improve health and prevent disease. The
obvious issues are why, how, and when we should change our
traditional public health-oriented interventions to become
more targeted on the basis of individual differential
susceptibilities to disease." |
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Muin J. Khoury, MD, PhD
Centers for Disease Control and Prevention
Director, Office of Genomics and Disease Prevention |
Content in this module includes
- Prevalence of iron overload and HFE gene mutations.
- Patients at risk for iron overload, hemochromatosis, and hereditary
hemochromatosis.
- Penetrance of HFE gene mutations.
- Population screening.
- Understanding iron overload in the context of the patient’s family and
medical history.
- Evaluating iron overload in the context of the patient’s medical and
family history.
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