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FY 2005 Bench-to-Bedside Projects
GENERAL CATEGORY:
Institute(s)
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Project
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Investigators
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NINDS
NIDCD
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"Induction of volitional swallowing in chronic dysphagia post stroke: A novel
mechanism-based intervention"
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PI: C. Ludlow, PhD, NINDS
PI: L. Cohen, MD, NINDS
PI: B. Horwitz, PhD, NIDCD
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NHLBI
NINDS
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"Induction of Mucosal Tolerance to Recombinant Human E-Selectin for the treatment of
Myocardial Ischemia-Reperfusion Injury and Symptomatic Coronary
Atherosclerosis. A Collaborative NHLBI/NINDS Investigation"
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PI: R. deSilva, MB, BS, PhD, NHLBI
PI: J. Hallenbeck, MD, NINDS
PI: T. Finkel, MD, PhD, NHLBI
AIs from NHLBI, NINDS
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RARE DISEASES CATEGORY:
Institute(s)
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Project
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Investigators
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NCI
NHGRI
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"Natural history, biology and treatment of dermal neurofibromas in neurofibromatosis
type 1 (NF1)"
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PI: B. Widemann, MD, NCI
PI: D. Stewart, MD, NHGRI
AIs from NCI, NHGRI, Medical Numerics, Inc., Univ of
AL
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NHGRI
NHLBI
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"Testing Treatment of Hutchinson-Gilford Progeria Syndrome with Farnesyl Transferase
Inhibitors"
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PI: L. Gordon, MD, PhD,
NHGRI
PI: D. Orlic, PhD, NHLBI
AIs: Drs. W. Introne, W. Gahl, F. Collins, E. Nabel
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NIEHS
NINDS
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"Analysis of global gene expression patterns and mitochondrial DNA damage in
lymphocytes of Friedreich’s Ataxia patients undergoing idebenone treatment in
Phase II double-blind placebo controlled study"
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PI: B. Van Houten, PhD,
NIEHS
PI: K. Fischbeck, MD, NINDS
AIs: A. Haugen, NIEHS, N. DiProspero, NINDS
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NCI
CC, DTM
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"Adoptive Cell Therapy for Ewing’s Sarcoma Using Artificial Antigen Presenting Cells"
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PI: C. Mackall, M.D.
AIs from CC, NCI, Univ of PA
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NICHD
NHGRI
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"Ganaxolone Therapy for Niemann-Pick Type C"
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PI: F. Porter, MD, PhD,
NICHD
PI: W. Pavan, PhD, NHGRI
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NIEHS
NICHD
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"UVA Sensitivity in Smith-Lemli-Opitz Syndrome: Possible Involvement of Cholesta
-5,7,9(11)-trien-3-ol
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PI: C. Chignell, PhD, NIEHS
PI: F. Porter, MD, PhD, NICHD
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CC
NCI
NIAID
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"Pre-clinical and clinical investigations into the mechanisms and efficacy of
extracorporeal photopheresis (ECP) in the abrogation of graft-vs-host disease
(GVHD) and facilitation of graft-vs-tumor (GVT) immunity in pediatric
patients"
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PI: A. Wayne, MD, NCI
PI: T. J. Fry, MD, NCI
AIs: Drs. Bolan, Leitman, Malech, Pavletic
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NCI, NICHD
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"Site-Selective cAMP Analogs for Treatment of Carney Complex"
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PI: Y. Cho-Chung, MD, PhD,
NCI
PI: C. Stratakis, MD, NICHD
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NIAMS
NHGRI
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"Pathogenesis of and risk factors for autoimmunity in the Wiskott-Aldrich Syndrome"
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PI: F. Candotti, MD, NHGRI
PI: R. Siegel, MD, PhD, NIAMS
AI: N. Nikolov, MD, NIAMS
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NIAID
NCI
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"Development of a Specific Drug treatment for WHIM Syndrome"
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PI: D. McDermott, MD, NIAID
PI: P. Murphy, MD, NIAID
PI: H. Malech, MD, NIAID
S. Hwang, MD, PhD, NCI
AI: T. Kawai, MD, NIAID
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AIDS CATEGORY:
Institute(s)
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Project
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Investigators
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NCI
NIAID
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"Role of HIV-1 RNase in Developing Resistance to Nucleoside Analogs"
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PI: V. Pathak, PhD, NCI
PI: F. Maldarelli, MD, PhD, NCI
AI: C. Morse, MD, NIAID
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NHLBI
CC
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"Endothelial Dysfunction in HIV-associated Pulmonary Hypertension"
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PI: R. Machado, MD, NHLBI
PI: N. Raghavachari, Ph.D., CC, CCMD
PI: M. Gladwin, MD, NHLBI
AIs: Drs. Barnett, Masur, Lederman, McCoy, Solomon
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NCI
NIAID
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"Clinical Development of E. coli Nissle 1917 as Host for a Live Anti-HIV Microbicide"
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PI: D. Hamer, PhD, NCI
PI: I. Sereti, MD, NIAID
AIs: Drs. Asdhya, Henry, Mannon
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NIAID
CC
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"Persistent HIV Reservoirs in Infected Patients Receiving Effective Antiviral Therapy for
Prolonged Periods of Time: Delineation of the Mechanism and Source of Viral
Replication and Execution of a New Therapeutic Strategy"
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PI: T. Chun, PhD, NIAID
PI: L. Healey, MD, CCMD
AIs: Drs. Moir, Kovacs, Kottilil |
CC
NIAID
NINDS
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"Identification of Biomarkers of Mitochondrial-related Drug Toxicities in HIV-infected
Patients Receiving Highly Active Anti-retroviral Therapy"
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PI: J. Kovacs, MD, CCMD
PI: J. Mican, MD, NIAID
AIs: from CCMD, DLM, NINDS
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Awards Funded
2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999
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