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Southern California Particle Center and Supersite (SCPCS)
EPA Grant Number: R827352Center: Southern California Particle Center and Supersite
Center Director: Froines, John R.
Title: Southern California Particle Center and Supersite (SCPCS)
Investigators: Froines, John R. , Avol, Edward L. , Cass, Glen , Cho, Arthur K. , Cohen, Yoram , Colome, Steven D. , Eastmond, David A. , Eldering, Annmarie , Friedlander, Sheldon , Gauderman, William , Gong, Henry , Grosser, Stella C. , Hankinson, Oliver , Hinds, William C. , Kleinman, Michael T. , Nel, Andre E. , Peters, John M. , Phalen, Robert , Que Hee, Shane S. , Ritz, Beate R. , Sioutas, Constantinos , Thomas, Duncan C. , Turco, Richard , Venkatesan, M. Indira , Winer, Arthur M. , Yu, Rong Chun , Ziemann, Paul J.
Current Investigators: Froines, John R. , Arey, Janet , Atkinson, Roger , Avol, Edward L. , Berhane, Kiros , Charles, Judith M. , Cho, Arthur K. , Fukuto, Jon , Gauderman, William , Gong, Henry , Harkema, Jack , Hinds, William C. , Kleinman, Michael T. , Kumagai, Yoshito , Kunzli, Nino , Linn, William S. , Lurmann, Fred , McConnell, Rob , Miguel, Antonio , Nel, Andre E. , Peters, John M. , Phalen, Robert , Ritz, Beate R. , Schiestl, Robert H. , Sioutas, Constantinos , Stram, Dan , Turco, Richard , Winer, Arthur M. , Yu, Rong Chun
Institution: University of California - Los Angeles
Current Institution: University of California - Los Angeles , Michigan State University , Rancho Los Amigos Medical Center , Sonoma Technology, Inc. , University of California - Davis , University of California - Irvine , University of California - Riverside , University of Southern California , University of Tsukuba
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Amount: $8,715,583
RFA: Airborne Particulate Matter (PM) Centers (1999)
Research Category: Particulate Matter
Description:
Objective:The overall objective of the Southern California Particle Center and Supersite (SCPCS) is to bring together outstanding scientists from the leading universities in Southern California to identify and conduct high priority research to better understand the effects of particulate matter (PM) and ensure protection of public health. The SCPCS makes use of an integrated approach to address each of the areas of Exposure, Dosimetry, Toxicology, and Epidemiology. This integration is accomplished by seeking out and involving in the Center some of the major figures in air quality and environmental health. A team has been assembled for SCPCS that is committed to the need for strong cross- and interdisciplinary programs of research in order to address the challenging issues posed by PM. By improving our fundamental and observational understanding of the complex relation between particle exposure and human health, it is our goal to lay a firm scientific foundation for effective intervention strategies for public health protection.
The Center will conduct research that addresses the objectives listed in the March, 1998 NRC report entitled Research Priorities for Airborne Particulate Matter: 1. Immediate Priorities and Long-Range Research Portfolio. The projects of this Center are based on the ten research priorities outlined in the NRC report. Related research objectives of the SCPCS include: To make use of ambient particle concentrators for exposure assessment and toxicological research; To emphasize chemical and physical characterization of PM, especially size distribution, in the study of the relationship between PM and associated morbidity and mortality; To emphasize mechanistic toxicological research including in vitro, animal and human approaches for better understanding of the underlying bases for increased morbidity and mortality associated with exposure to PM; To conduct toxicologic research which reduces the uncertainties in the identification of causitive PM constituents; To investigate the role of allergens and bioaerosols in the morbidity and mortality associated with PM exposure; to better characterize the relationship between mobile sources and airborne PM in the Southern California air basin; and, To investigate the relation between outdoor, indoor and personal exposure to PM.
Approach:The SCPCS addresses each of four disciplinary areas central to understanding the complex particulate matter issue. These areas of Exposure, Toxicology, and Epidemiology form the Research Cores of SCPCS. To assist the Research Cores we have established four support Cores. The Biostatistics Core will provide statistical support for research projects conducted by Center investigators and to investigate design and statistical analysis issues related to the Center research studies. The Concentrator Exposure Facility is designed to conduct inhalation studies to ambient course, fine and ultrafine particles. This core provides a unique transportable exposure facility capable of concentrating ambient particles for use in toxicologic tests with laboratory animals and clinical exposures with humans. Recent technology developments allow for the concentration of real ambient particles rather than generation of synthetic or re-suspended aerosols for toxicological studies. This opens the possibility of conducting experiments over a full range of realistic concentrations and for particulate matter levels found in episode conditions. The Analytical Chemistry Core is to provide high quality, state of the art, analytical chemistry services as well as field and laboratory exposure characterization capability to Center investigators. This service core integrates the analytical and field sampling resources on the UCLA campus into a well defined and organized structure. The Dosimetry Core will be considered both a research and support core. This core will support Center investigators with dose calculations for Exposure, Toxicology, and Epidemiology projects. The core will also initiate original research in collaboration with other investigators to improve the design and interpretation of studies as well as to improve dosimetry models.
Southern California also has some important resources that reinforce the Center's focus and leverages EPA's investment in a Los Angeles-based center. These resources include an NIEHS Environmental Health Sciences Center, a joint EPA/NIEHS Children's Health Center, an excellent network of PM monitors sponsored or operated by the California Air Resources Board (ARB), EPA, and the South Coast Air Quality Management District (SCAQMD).
An Administrative Core will coordinate the multi-campus research effort, provide for internal program review, and work to ensure that the team functions effectively as a center by encouraging and maximizing cross campus and interdisciplinary activities. An Internal Advisory Committee will be established to ensure that effective interaction across Cores is occurring, to identify new research priorities and projects, to evaluate the overall research productivity, to determine appropriate commitments to Center research activities, and to insure young investigators are being encouraged to participate in the Center.
The approach of SCPCS is to seek out projects for support under the Research Cores that address one or more of the top ten research priorities for PM that were identified in the March, 1998 NRC Research Priorities report. We have assembled a strong program of research that addresses the NRC priorities. The SCPCS is comprised of nine initial projects within the Research Cores. Specific SCPCS projects in the Exposure Core focus on aerosol characterization, personal exposure, and exposure modeling.
Activities under the aerosol characterization project include the development of a mobile Particle Instrumentation Unit (PIU) that will be used for mechanistic aerosol field studies as well as studies in this and other Research Cores that require state-of-art PM measurements. Other studies within this area include characterization of ambient ultrafine aerosols prior to planned toxicologic studies. Characterization studies will also be conducted for aerosol constituents such as PAH compounds, metals, and oxidants. Within the aerosol characterization project area we will evaluate sources and concentrations of aero-allergens in Southern California.
In the personal exposure project area we will conduct personal and residential measurement of aerosol exposure and concentration in schoolchildren (sensitive population) participating in an ongoing study in the Epidemiology Core. Integrated particle samples will be collected in three size ranges: 0-1, 1-2.5 and 2.5-10m. Real-time variation will be monitored with nephelometers. Data obtained in this study will be used to validate probabilistic population exposure models for PM.
The exposure modeling studies will connect sources of PM constituents with regional air quality and human exposures. The modeling efforts will be fundamental, involving chemical kinetics and mechanisms and will support exposure studies in this and other Research Cores. Modeling efforts will include trajectory aerosol modeling, regional exposure modeling, the SMOG air quality model and the REHEX Regional Exposure Model.
The Toxicology Research Core initially involves four projects. The aim of the projects in this research core focus on: 1) identification of physical and chemical components of PM that generate or enhance the following pathological responses: IgE production, airway inflammation, airway hyper-reactivity, bronchial hyper-reactivity, cardiac and systemic coagulation abnormalities, production of reactive oxygen species and DNA adducts., and 2) determination of the biological mechanisms whereby the identified responsible components of PM elicit the above pathological responses.
In the asthma exacerbation study a mouse model will be used to test the hypothesis that PM enhances antigen-specific IgE response. Further testing will be conducted to identify mechanisms and components of PM responsible for exacerbation of asthma response. This project will test the hypothesis that airborne particles enhance antigen-specific IgE response in mice, and seeks to identify the responsible physical and chemical constituents causing this effect.
In the allergic inflammation study in-vitro cell cultures and the asthma mouse model will be used to examine adjuvant effects of PAH and redox-active quinones in PM on allergic inflammation. The hypothesis in this study is that PAH compounds induce P4501A1 (CYP1A1) expression through interaction with the AHR in cell types such as macrophages and epithelial cells. Specific objectives are to: 1) establish relevant models for OVA-induced asthma in mice to determine whether concomitant exposure to PAH and redox-active quinones will enhance allergic inflammation and airway hyperreactivity, and 2) conduct in vitro cell culture experiments to determine the effects of PAH and redox active quinones on the induction of cytokine and chemokine messages in pulmonary alveolar macrophages, epithelial cells and their cell lines.
In the airborne PM and quinone study, quinone reaction with nucleophiles will be examined for adduct formation that may act as antigens and chemical carcinogens. The hypothesis to be tested is that PM contain quinones that react with tissue nucleophiles to form adducts that act as antigens, catalysts for reactive oxygen mediated toxicity and chemical carcinogens. This project will be linked with the epidemiology core in the third year of the Center to assess PM in areas with known high incidence of asthma.
In the human clinical exposure study, chamber studies will be conducted on human volunteers to evaluate acute cardiopulmonary responses to concentrated ambient ultrafine, fine and coarse PM. Testing will be conducted on subjects with COPD following exposure to concentrated ambient aerosols. The hypothesis to be tested in this study is that controlled exposure to concentrated particles elicit statistically or clinically significant acute pulmonary or systemic responses in human volunteers. This hypothesis will be tested in multiple experiments involving different particle size ranges and susceptible human population.
The Epidemiology Research Core builds on an already established respiratory disease core of the NIEHS supported Environmental Health Sciences Center. The new activities of the SCPCS Center serve to strengthen an ongoing major inquiry into the chronic health effects of air pollution in Southern California children supported by the California Air Resources Board. In that study about 4000 school children living in twelve communities with differing levels and types of air pollution have been under study since 1993. While interesting findings have emerged from this study suggesting a relationship between pollution levels and health effects, there are still many questions that can only be addressed through more careful examination of dosimetry. The SCPCS supports two new projects initiated to address issues of key concern in this study. The mobile source study estimates exposure to and examines the influence of mobile source emissions on respiratory effects in the participating school children using information on traffic density and proximity of roadways. The bioaerosol study tests for the respiratory health effects of measured bioaerosols (including pollens, spores and fungi) within the same epidemiologic study.
Expected Results:The Los Angeles Basin is home to more than 14 million individuals who breathe the most polluted air in the nation. The Research Core projects in this Center application were selected with attention to the public health objectives of the RFA and the ten major NRC objectives. Through projects described in this application the airshed will receive detailed characterization by exposure studies to assess PM size, composition, and spatial variability. Toxicology investigations will be directed toward a fundamental understanding of the mechanisms and the chemical and physical components of PM. The epidemiologic research on bioaerosols and vehicular exposure are likely to provide new information to enhance our ability to detect human health effects from ambient air pollution. New epidemiologic studies will be designed to begin in year 3 to apply the toxicologic research and exposure characterization to investigations of sensitive populations, particularly children and asthmatics. Novel studies will be conducted on human activities and allergens in airborne particulate matter, and their role in respiratory disease. The relationships will be quantified between indoor and outdoor particle levels and personal exposure to particulate matter. This will be conducted for schoolchildren participating in a major epidemiology study within the Los Angeles Air Basin (LAB). A coordinated modeling and analysis program will link aerosol sources and monitoring data with particulate properties and human exposure, from source/receptor relationships to regional scale simulations for the LAB, which will provide a more substantial basis for interpreting and applying experimental data, and in designing regulatory actions. Toxicology experiments will address exacerbation of the asthmatic response in a mouse model, stimulation of production of reactive oxygen species and DNA adducts in a rat model, and acute elicitation of pathological pulmonary and cardiac responses in potentially susceptible human populations. Complementary studies will seek to define the mechanisms and pathways whereby PM and the relevant causative constituents of PM elicit the above pathological responses. Successful completion of the toxicology studies will provide information that is essential for the future design of methodologies for identifying susceptible human populations and for preventing or ameliorating the deleterious effects of PM on the general population.
Journal Articles: 135 Displayed | Download in RIS Format
| Other center views: | All 136 publications | 135 publications in selected types | All 135 journal articles |
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Arellanes C, Paulson SE, Fine PM, Sioutas C. Exceeding of Henry’s Law by hydrogen peroxide associated with urban aerosols. Environmental Science & Technology 2006;40(16):4859-4866. |
R827352 (Final) |
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Arhami M, Kuhn T, Fine PM, Delfino RJ, Sioutas C. Effects of sampling artifacts and operating parameters on the performance of a semicontinuous particulate elemental carbon/organic carbon monitor. Environmental Science & Technology 2006;40(3):945-954. |
R827352 (Final) |
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Becker S, Soukup JM, Sioutas C, Cassee FR. Response of human alveolar macrophages to ultrafine, fine, and coarse urban air pollution particles. Experimental Lung Research 2003;29(1):29-44. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Biswas S, Fine PM, Geller MD, Hering SV, Sioutas C. Performance evaluation of a recently developed water-based condensation particle counter. Aerosol Science and Technology 2005;39(5):419-427. |
R827352 (Final) R827352C014 (Final) |
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Campbell A, Oldham M, Becaria A, Bondy SC, Meacher D, Sioutas C, Misra C, Mendez LB, Kleinman M. Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain. Neurotoxicology 2005;26(1):133-140. |
R827352 (2004) R827352 (Final) R827352C005 (Final) R827352C014 (Final) |
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Chakrabarti B, Singh M, Sioutas C. Development of a near-continuous monitor for measurement of the sub-150 nm PM mass concentration. Aerosol Science and Technology 2004;38(Suppl 1):239-252. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Chakrabarti B, Fine PM, Delfino R, Sioutas C. Performance evaluation of an active-flow personal DataRAM PM2.5 mass monitor (Thermo Anderson pDR-1200) designed for continuous personal exposure measurements. Atmospheric Environment 2004;38(20):3329-3340. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Chan RC-F, Wang M, Li N, Yanagawa Y, Onoe K, Lee JJ, Nel AE. Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation. Journal of Allergy and Clinical Immunology 2006;118(2):455-465. |
R827352 (Final) R827352C002 (Final) R832413 (2008) R832413C002 (2007) R832413C002 (2008) |
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Chang M, Sioutas C, Cassee FR, Fokkens PHB. Field evaluation of a mobile high-capacity particle size classifier (HCPSC) for separate collection of coarse, fine and ultrafine particles. Journal of Aerosol Science 2001;32(1):139-156. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Chang M-C, Geller MD, Sioutas C, Fokkens PHB, Cassee FR. Development and evaluation of a compact, highly efficient coarse particle concentration for toxicological studies. Aerosol Science and Technology 2002;36(4):492-501. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Cho AK, Di Stefano E, You Y, Rodriquez CE, Schmitz DA, Kumagai Y, Miguel AH, Eiguren-Fernandez A, Kobayashi T, Avol E, Froines JR. Determination of four quinones in diesel exhaust particles, SRM 1649a and atmospheric PM2.5. Aerosol Science and Technology 2004;38(Suppl 1):68-81. |
R827352 (Final) R827352C001 (Final) R827352C009 (Final) R827352C013 (Final) R831861 (2004) R831861 (2005) |
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Cho AK, Sioutas C, Miguel AH, Kumagai Y, Schmitz DA, Singh M, Eiguren-Fernandez A, Froines JR. Redox activity of airborne particulate matter at different sites in the Los Angeles Basin. Environmental Research 2005;99(1):40-47. |
R827352 (Final) R827352C001 (Final) R827352C013 (Final) R827352C014 (Final) |
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Cui Y, Zhang Z-F, Froines J, Zhao J, Wang H, Yu S-Z, Detels R. Air pollution and case fatality of SARS in the People’s Republic of China: an ecologic study. Environmental Health 2003;2(1):15. |
R827352 (2004) R827352 (Final) |
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de Pereira PA, de Andrade JB, Miguel AH. Determination of 16 priority polycyclic aromatic hydrocarbons in particulate matter by HRGC-MS after extraction by sonication. Analytical Sciences 2001;17(10):1229-1231. |
R827352 (Final) R827352C013 (Final) |
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de Pereira PA, de Andrade JB, Miguel AH. Measurements of semivolatile and particulate polycyclic aromatic hydrocarbons in a bus station and an urban tunnel in Salvador, Brazil. Journal of Environmental Monitoring 2002;4(4):558-561. |
R827352 (2004) R827352 (Final) R827352C013 (Final) |
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De Vizcaya-Ruiz A, Gutierrez-Castillo ME, Uribe-Ramirez M, Cebrian ME, Mugica-Alvarez V, Sepulveda J, Rosas I, Salinas E, Garcia-Cuellar C, Martinez F, Alfaro-Moreno E, Torres-Flores V, Osornio-Vargas A, Sioutas C, Fine PM, Singh M, Geller MD, Kuhn T, Miguel AH, Eiguren-Fernandez A, Schiestl RH, Reliene R, Froines J. Characterization and in vitro biological effects of concentrated particulate matter from Mexico City. Atmospheric Environment 2006;40(Suppl 2):583-592. |
R827352 (Final) |
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Delfino RJ, Sioutas C, Malik S. Potential role of ultrafine particles in association between airborne particle mass and cardiovascular health. Environmental Health Perspectives 2005;113(8):934-946. |
R827352 (Final) R827352C014 (Final) |
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Doherty SP, Prophete C, Maciejczyk P, Salnikow K, Gould T, Larson T, Koenig J, Jaques P, Sioutas C, Zelikoff JT, Lippmann M, Cohen MD. Detection of changes in alveolar macrophage iron status induced by select PM2.5-associated components using iron-response protein binding activity. Inhalation Toxicology 2007;19(6-7):553-562. |
R827352 (Final) R827351 (Final) R827355 (2004) R827355 (Final) |
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Eiguren-Fernandez A, Miguel AH. Determination of semivolatile and particulate polycyclic aromatic hydrocarbons in SRM 1649a and PM2.5 samples by HPLC-fluorescence. Polycyclic Aromatic Compounds 2003;23(2):193-205. |
R827352 (2004) R827352 (Final) R827352C013 (Final) |
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Eiguren-Fernandez A, Miguel AH, Jaques PA, Sioutas C. Evaluation of a denuder-MOUDI-PUF sampling system to measure the size distribution of semi-volatile polycyclic aromatic hydrocarbons in the atmosphere. Aerosol Science and Technology 2003;37(3):201-209. |
R827352 (2004) R827352 (Final) R827352C013 (Final) R827352C014 (Final) |
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Eiguren-Fernandez A, Miguel AH, Froines JR, Thurairatnam S, Avol EL. Seasonal and spatial variation of polycyclic aromatic hydrocarbons in vapor-phase and PM2.5 in Southern California urban and rural communities. Aerosol Science and Technology 2004;38:447-455. |
R827352 (2004) R827352 (Final) R827352C009 (Final) R827352C013 (Final) R831861 (2005) |
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Eiguren-Fernandez A, Avol EL, Thurairatnam S, Hakami M, Froines JR, Miguel AH. Seasonal influence on vapor- and particle-phase polycyclic aromatic hydrocarbon concentrations in school communities located in Southern California. Aerosol Science and Technology 2007;41(4):438-446. |
R827352 (Final) R827352C009 (Final) R827352C013 (Final) R832413 (2008) R832413C003 (2007) R832413C003 (2008) |
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Eiguren-Fernandez A, Miguel AH, Lu R, Purvis K, Grant B, Mayo P, Di Stefano E, Cho AK, Froines J. Atmospheric formation of 9,10-phenanthraquinone in the Los Angeles air basin. Atmospheric Environment 2008;42(10):2312-2319. |
R827352 (Final) R832413 (2007) R832413 (2008) R832413C003 (2007) R832413C003 (2008) |
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Fine PM, Jaques PA, Hering SV, Sioutas C. Performance evaluation and use of a continuous monitor for measuring size-fractionated PM2.5 nitrate. Aerosol Science and Technology 2003;37(4):342-354. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Fine PM, Chakrabarti B, Krudysz M, Schauer JJ, Sioutas C. Diurnal variations of individual organic compound constituents of ultrafine and accumulation mode particulate matter in the Los Angeles Basin. Environmental Science & Technology 2004;38(5):1296-1304. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Fine PM, Shen S, Sioutas C. Inferring the sources of fine and ultrafine particulate matter at downwind receptor sites in the Los Angeles Basin using multiple continuous measurements. Aerosol Science and Technology 2004;38(S1):182-195. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Fruin SA, St Denis MJ, Winer AM, Colome SD, Lurmann FW. Reductions in human benzene exposure in the California South Coast Air Basin. Atmospheric Environment 2001;35(6):1069-1077. |
R827352 (2004) R827352 (Final) R827352C015 (Final) |
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Gauderman WJ, Avol E, Lurmann F, Kuenzli N, Gilliland F, Peters J, McConnell R. Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology 2005;16(6):737-743. |
R827352 (Final) R827352C007 (Final) R827352C009 (Final) R831861 (2004) R831861 (2005) R831861C001 (2005) |
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Gauderman WJ, Vora H, McConnell R, Berhane K, Gilliland F, Thomas D, Lurmann F, Avol E, Kunzli N, Jerrett M, Peters J. Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. The Lancet 2007;369(9561):571-577. |
R827352 (Final) R827352C007 (Final) R831861 (2005) |
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Geller MD, Kim S, Misra C, Sioutas C, Olson BA, Marple VA. A methodology for measuring size-dependent chemical composition of ultrafine particles. Aerosol Science and Technology 2002;36(6):748-763. |
R827352 (2004) R827352 (Final) R827352C014 (Final) R828678C009 (2002) |
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Geller MD, Fine PM, Sioutas C. The relationship between real-time and time-integrated coarse (2.5-10 μm), intermodal (1-2.5 μm), and fine (<2.5 μm) particulate matter in the Los Angeles Basin. Journal of the Air & Waste Management Association 2004;54(9):1029-1039. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Geller MD, Sardar SB, Phuleria H, Fine PM, Sioutas C. Measurements of particle number and mass concentrations and size distributions in a tunnel environment. Environmental Science & Technology 2005;39(22):8653-8663. |
R827352 (Final) R827352C014 (Final) |
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Geller MD, Ntziachristos L, Mamakos A, Samaras Z, Schmitz DA, Froines JR, Sioutas C. Physicochemical and redox characteristics of particulate matter (PM) emitted from gasoline and diesel passenger cars. Atmospheric Environment 2006;40(36):6988-7004. |
R827352 (Final) |
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Geller M, Biswas S, Sioutas C. Determination of particle effective density in urban environments with a differential mobility analyzer and aerosol particle mass analyzer. Aerosol Science and Technology 2006;40(9):709-723. |
R827352 (Final) |
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Gong H, Sioutas C, Linn WS, Clark KW, Terrell SL, Terrell LL, Anderson KR, Kim S, Chang M-C. Controlled human exposures to concentrated ambient fine particles in metropolitan Los Angeles: methodology and preliminary health-effect findings. Inhalation Toxicology 2000;12(1):107-119. |
R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Gong H Jr, Linn WS, Sioutas C, Terrell SL, Clark KW, Anderson KR, Terrell LL. Controlled exposures of healthy and asthmatic volunteers to concentrated ambient fine particles in Los Angeles. Inhalation Toxicology 2003;15(4):305-325. |
R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R831861 (2005) |
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Gong H Jr, Linn WS, Terrell SL, Clark KW, Geller MD, Anderson KR, Cascio WE, Sioutas C, Cascio WE, Sioutas C. Altered heart-rate variability in asthmatic and healthy volunteers exposed to concentrated ambient coarse particles. Inhalation Toxicology 2004;16(6-7):335-343. |
R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) |
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Gong H Jr, Linn WS, Terrell SL, Anderson KR, Clark KW, Sioutas C, Cascio WE, Alexis N, Devlin RB. Exposures of elderly volunteers with and without chronic obstructive pulmonary disease (COPD) to concentrated ambient fine particulate pollution. Inhalation Toxicology 2004;16(11-12):731-744. |
R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R827999 (Final) R831861 (2005) |
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Gong H Jr, Linn WS, Clark KW, Anderson KR, Geller MD, Sioutas C. Respiratory responses to exposures with fine particulates and nitrogen dioxide in the elderly with and without COPD. Inhalation Toxicology 2005;17(3):123-132. |
R827352 (Final) R827352C012 (Final) R827352C014 (Final) R827999 (Final) R831861 (2005) |
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Gong Jr. H, Linn WS, Clark KW, Anderson KR, Sioutas C, Alexis NE, Cascio WE, Devlin RB. Exposures of healthy and asthmatic volunteers to concentrated ambient ultrafine particles in Los Angeles. Inhalation Toxicology 2008;20(6):533-545. |
R827352 (Final) R832413 (2007) R832413 (2008) R832413C001 (2007) R832413C001 (2008) |
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Hao M, Comier S, Wang M, Lee JJ, Nel A. Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models. Journal of Allergy and Clinical Immunology 2003;112(5):905-914. |
R827352 (2004) R827352 (Final) R827352C002 (Final) |
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Hasson AS, Paulson SE. An investigation of the relationship between gas-phase and aerosol-borne hydroperoxides in urban air. Journal of Aerosol Science 2003;34(4):459-468. |
R827352 (2004) R827352 (Final) |
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Hering S, Fine PM, Sioutas C, Jaques PA, Ambs JL, Hogrefe O, Demerjian KL. Field assessment of the dynamics of particulate nitrate vaporization using differential TEOM and automated nitrate monitors. Atmospheric Environment 2004;38(31):5183-5192. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Hiura TS, Li N, Kaplan R, Horwitz M, Seagrave J-C, Nel AE. The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles. Journal of Immunology 2000;165(5):2703-2711. |
R827352 (2004) R827352 (Final) R827352C002 (Final) |
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Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines JR, Kumagai Y. Effects of a single intratracheal administration of phenanthraquinone on murine lung. Journal of Applied Toxicology 2005;25(1):47-51. |
R827352 (2004) R827352 (Final) R827352C001 (Final) |
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Houston D, Wu J, Ong P, Winer A. Structural disparities of urban traffic in Southern California: implications for vehicle-related air pollution exposure in minority and high-poverty neighborhoods. Journal of Urban Affairs 2004;26(5):565-592. |
R827352 (2004) R827352 (Final) R827352C015 (Final) |
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Houston D, Ong P, Wu J, Winer A. Proximity of licensed child care facilities to near-roadway vehicle pollution. American Journal of Public Health 2006;96(9):1611-1617. |
R827352 (Final) R827352C015 (Final) |
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Jaques PA, Ambs JL, Grant WL, Sioutas C. Field evaluation of the differential TEOM monitor for continuous PM2.5 mass concentrations. Aerosol Science and Technology 2004;38(Suppl 1):49-59. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Khlystov A, Zhang Q, Jimenez JL, Stanier C, Pandis SN, Canagaratna MR, Fine P, Misra C, Sioutas C. In-situ concentration of semi-volatile aerosol using water-condensation technology. Journal of Aerosol Science 2005;36(7):866-880. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, Kumagai Y. 1,2-Napthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea. Toxicology and Applied Pharmacology 2006;210(1-2):47-54. |
R827352 (Final) R827352C001 (Final) |
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Kim HT, Zhu Y, Hinds WC, Lee KW. Experimental study of small cyclones as particle concentrators. Journal of Aerosol Science 2002;33(5):721-733. |
R827352 (Final) R827352C006 (Final) |
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Kim S, Chang M-C, Kim D, Sioutas C. A new generation of portable coarse, fine, and ultrafine particle concentrators for use in inhalation toxicology. Inhalation Toxicology 2000;12(1-2):121-137. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Kim S, Sioutas C, Chang M-C, Gong Jr H. Factors affecting the stability of the performance of ambient fine-particle concentrators. Inhalation Toxicology 2000;12(11, Suppl 4):281-298. |
R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R825513C024 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R828598C700 (Final) R829095C004 (2005) |
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Kim S, Jaques PA, Chang M, Froines JR, Sioutas C. Versatile aerosol concentration enrichment system (VACES) for simultaneous in vivo and in vitro evaluation of toxic effects of ultrafine, fine and coarse ambient particles. Part I: Development and laboratory characterization. Journal of Aerosol Science 2001;32(11):1281-1297. |
R827352 (Final) R827352C014 (Final) |
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Kim S, Jaques PA, Chang M, Barone T, Xiong C, Friedlander SK, Sioutas C. Versatile aerosol concentration enrichment system (VACES) for simultaneous in vivo and in vitro evaluation of toxic effects of ultrafine, fine and coarse ambient particles. Part II: Field evaluation. Journal of Aerosol Science 2001;32(11):1299-1314. |
R827352 (2004) R827352 (Final) R827352C003 (Final) R827352C014 (Final) R826232 (2000) |
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Kim S, Shen S, Sioutas C, Zhu Y, Hinds WC. Size distribution and diurnal and seasonal trends of ultrafine particles in source and receptor sites of the Los Angeles Basin. Journal of the Air & Waste Management Association 2002;52(3):297-307. |
R827352 (2004) R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
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Kleinman MT, Hamade A, Meacher D, Oldham M, Sioutas C, Chakrabarti B, Stram D, Froines JR, Cho AK. Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Journal of the Air & Waste Management Association 2005;55(9):1277-1288. |
R827352 (2004) R827352 (Final) R827352C001 (Final) R827352C005 (Final) R827352C014 (Final) |
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Kleinman MT, Sioutas C, Froines JR, Fanning E, Hamade A, Mendez L, Meacher D, Oldham M. Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Inhalation Toxicology 2007;19(Suppl 1):117-126. |
R827352 (Final) R832413 (2008) R832413C001 (2007) R832413C001 (2008) R832413C003 (2007) |
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Kuhn T, Biswas S, Fine PM, Geller M, Sioutas C. Physical and chemical characteristics and volatility of PM in the proximity of a light-duty vehicle freeway. Aerosol Science and Technology 2005;39(4):347-357. |
R827352 (Final) R827352C014 (Final) |
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Kuhn T, Krudysz M, Zhu Y, Fine PM, Hinds WC, Froines J, Sioutas C. Volatility of indoor and outdoor ultrafine particulate matter near a freeway. Journal of Aerosol Science 2005;36(3):291-302. |
R827352 (2004) R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
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Lee JH, Hopke PK, Holsen TM, Lee D-W, Jaques PA, Sioutas C, Ambs JL. Performance evaluation of continuous PM2.5 mass concentration monitors. Journal of Aerosol Science 2005;36(1):95-109. |
R827352 (Final) R827352C014 (Final) |
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Li N, Venkatesan MI, Miguel A, Kaplan R, Gujuluva C, Alam J, Nel A. Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element. Journal of Immunology 2000;165(6):3393-3401. |
R827352 (2004) R827352 (Final) R827352C002 (Final) R827352C013 (Final) |
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Li N, Kim S, Wang M, Froines J, Sioutas C, Nel A. Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter. Inhalation Toxicology 2002;14(5):459-486. |
R827352 (2004) R827352 (Final) R827352C002 (Final) R827352C014 (Final) |
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Li N, Hao M, Phalen RF, Hinds WC, Nel AE. Particulate air pollutants and asthma: a paradigm for the role of oxidative stress in PM-induced adverse health effects. Clinical Immunology 2003;109(3):250-265. |
R827352 (2004) R827352 (Final) R827352C002 (Final) R827352C006 (Final) R827352C016 (Final) |
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Li N, Sioutas S, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberly T, Froines J, Nel A. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environmental Health Perspectives 2003;111(4):455-460. |
R827352 (2004) R827352 (Final) R827352C001 (Final) R827352C002 (Final) R827352C014 (Final) |
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Li N, Alam J, Venkatesan I, Eiguren-Fernandez A, Schmitz D, Di Stefano E, Slaughter N, Killeen E, Wang X, Huang A, Wang M, Miguel AH, Cho A, Sioutas C, Nel AE. Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals. Journal of Immunology 2004;173(5):3467-3481. |
R827352 (2004) R827352 (Final) R827352C001 (Final) R827352C002 (Final) R827352C013 (Final) R827352C014 (Final) |
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Li N, Nel AE. Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma. Antioxidants & Redox Signaling 2006;8(1-2):88-98. |
R827352 (Final) R827352C002 (Final) |
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Linn WS, Szlachcic Y, Gong Jr H, Kinney PL, Berhane KT. Air pollution and daily hospital admissions in metropolitan Los Angeles. Environmental Health Perspectives 2000;108(5):427-434. |
R827352 (2004) R827352 (Final) R827352C012 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) |
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Linn WS, Avila M, Gong H Jr. Exhaled nitric oxide: sources of error in offline measurement. Archives of Environmental Health 2004;59(8):385-391. |
R827352 (Final) R827352C011 (Final) R827352C012 (Final) R831861 (2005) |
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Lippmann M, Frampton M, Schwartz J, Dockery D, Schlesinger R, Koutrakis P, Froines J, Nel A, Finkelstein J, Godleski J, Kaufman J, Koenig J, Larson T, Luchtel D, Liu L-J S, Oberdorster G, Peters A, Sarnat J, Sioutas C, Suh H, Sullivan J, Utell M, Wichmann E, Zelikoff J. The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans. Environmental Health Perspectives 2003;111(8):1074-1092. |
R827352 (Final) R827352C002 (Final) R827352C014 (Final) R827351 (2002) R827351 (Final) R827353 (Final) R827353C006 (Final) R827353C015 (Final) R827354 (Final) R827355 (Final) |
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Lu R, Wu J, Turco RP, Winer AM, Atkinson R, Arey J, Paulson SE, Lurmann FW, Miguel AH, Eiguren-Fernandez A. Naphthalene distributions and human exposure in Southern California. Atmospheric Environment 2005;39:489-507. |
R827352 (2004) R827352 (Final) R827352C013 (Final) R827352C015 (Final) R831861 (2004) R831861 (2005) |
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Majestic BJ, Schauer JJ, Shafer MM, Turner JR, Fine PM, Singh M, Sioutas C. Development of a wet-chemical method for the speciation of iron in atmospheric aerosols. Environmental Science & Technology 2006;40(7):2346-2351. |
R827352 (Final) |
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McConnell R, Jones C, Milam J, Gonzalez P, Berhane K, Clement L, Richardson J, Hanley-Lopez J, Kwong K, Maalouf N, Galvan J, Platts-Mills T. Cockroach counts and house dust allergen concentrations after professional cockroach control and cleaning. Annals of Allergy, Asthma & Immunology 2003;91(6):546-552. |
R827352 (2004) R827352 (Final) R827352C007 (Final) R831861 (2004) R831861 (2005) |
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McConnell R, Berhane K, Gilliland FD, Molitor J, Thomas D, Lurmann F, Avol E, Gauderman WJ, Peters JM. Prospective study of air pollution and bronchitic symptoms in children with asthma. American Journal of Respiratory and Critical Care Medicine 2003;168(7):790-797. |
R827352 (2004) R827352 (Final) R827352C007 (Final) R827352C009 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (Final) R831861 (2004) R831861 (2005) |
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McConnell R, Berhane K, Molitor J, Gilliland F, Künzli N, Thorne P, Thomas D, Gauderman J, Avol E, Lurmann F, Rappaport E, Jerrett M, Peters JM. Dog ownership enhances symptomatic responses to air pollution in children with asthma. Environmental Health Perspectives 2006;114(12):1910-1915. |
R827352 (Final) R827352C007 (Final) R831861 (2005) |
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McConnell R, Berhane K, Yao L, Lurmann FW, Avol E, Peters JM. Predicting residential ozone deficits from nearby traffic. Science of the Total Environment 2006;363(1-3):166-174. |
R827352 (Final) R827352C007 (Final) R831861 (2004) R831861 (2005) R831861C001 (2005) |
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McConnell R, Berhane K, Yao L, Jerrett M, Lurmann F, Gilliland F, Kunzli N, Gauderman J, Avol E, Thomas D, Peters J. Traffic, susceptibility, and childhood asthma. Environmental Health Perspectives 2006;114(5):766-772. |
R827352 (Final) R827352C007 (Final) R831861 (2004) R831861 (2005) |
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Miguel AH, Eiguren-Fernandez A, Jaques PA, Froines JR, Grant BL, Mayo PR, Sioutas C. Seasonal variation of the particle size distribution of polycyclic aromatic hydrocarbons and of major aerosol species in Claremont, California. Atmospheric Environment 2004;38(20):3241-3251. |
R827352 (2004) R827352 (Final) R827352C013 (Final) R827352C014 (Final) |
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Miguel A, Eiguren-Fernandez A, Sioutas C, Fine P, Geller M, Mayo P. Observations of twelve USEPA priority polycyclic aromatic hydrocarbons in the Aitken size range (10-32 nm Dp). Aerosol Science and Technology 2005;39(5):415-418. |
R827352 (Final) R827352C013 (Final) R827352C014 (Final) |
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Misra C, Geller MD, Shah P, Sioutas C, Solomon PA. Development and evaluation of a continuous coarse (PM10 - PM2.5) particle monitor. Journal of the Air & Waste Management Association 2001;51(9):1309-1317. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Misra C, Kim S, Shen S, Sioutas C. A high flow rate, very low pressure drop impactor for inertial separation of ultrafine from accumulation mode particles. Journal of Aerosol Science 2002;33(5):735-752. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Misra C, Singh M, Shen S, Sioutas C, Hall PM. Development and evaluation of a personal cascade impactor sampler (PCIS). Journal of Aerosol Science 2002;33(7):1027-1047. |
R827352 (2004) R827352 (Final) R827352C014 (Final) R828678C007 (2001) R828678C007 (2002) R828678C007 (2003) R828678C007 (2004) R828678C007 (Final) R828678C009 (2003) R828678C009 (Final) |
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Misra C, Geller M, Sioutas C, Solomon P. Development and evaluation of a PM10 impactor-inlet for a continuous coarse particle monitor. Aerosol Science and Technology 2003;37(3):271-281. |
R827352 (Final) R827352C014 (Final) |
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Misra C, Fine PM, Singh M, Sioutas C. Development and evaluation of a compact facility for exposing humans to concentrated ambient ultrafine particles. Aerosol Science and Technology 2004;38(1):27-35. |
R827352 (2004) R827352 (Final) R827352C014 (Final) R828678C009 (2001) R828678C009 (Final) |
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Nel AE, Diaz-Sanchez D, Li N. The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. Current Opinion in Pulmonary Medicine 2001;7(1):20-26. |
R827352 (2004) R827352 (Final) R827352C002 (Final) |
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Nel AE. Air pollution-related illness: effects of particles. Science 2005;308(5723):804-806. |
R827352 (Final) R827352C002 (Final) |
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Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science 2006;311(5761):622-627. |
R827352 (Final) |
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Oldham MJ, Phalen RF. Dosimetry implications of upper tracheobronchial airway anatomy in two mouse varieties. The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology 2002;268(1):59-65. |
R827352 (2004) R827352 (Final) R827352C016 (Final) |
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Oldham MJ, Phalen RF, Robinson RJ, Kleinman MT. Performance of a portable whole-body mouse exposure system. Inhalation Toxicology 2004;16(9):657-662. |
R827352 (2004) R827352 (Final) R827352C005 (Final) R827352C016 (Final) |
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Pan C-JG, Schmitz DA, Cho AK, Froines J, Fukuto JM. Inherent redox properties of diesel exhaust particles: catalysis of the generation of reactive oxygen species by biological reductants. Toxicological Sciences 2004;81(1):225-232. |
R827352 (2004) R827352 (Final) R827352C001 (Final) |
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Phalen RF, Oldham MJ. Methods for modeling particle deposition as a function of age. Respiratory Physiology 2001;128(1):119-130. |
R827352 (2004) R827352 (Final) R827352C016 (Final) |
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Phalen RF, Oldham MJ, Nel AE. Tracheobronchial particle dose considerations for in vitro toxicology studies. Toxicological Sciences 2006;92(1):126-132. |
R827352 (Final) R827352C016 (Final) |
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Phalen R. The particulate air pollution controversy. Nonlinearity in Biology, Toxicology, and Medicine 2004;2(1):259-292. |
R827352 (2004) R827352 (Final) R827352C016 (Final) |
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Phousongphouang PT, Arey J. Sources of the atmospheric contaminants, 2-nitrobenzanthrone and 3-nitrobenzanthrone. Atmospheric Environment 2003;37(23):3189-3199. |
R827352 (Final) |
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Phuleria HC, Fine PM, Zhu Y, Sioutas C. Air quality impacts of the October 2003 Southern California wildfires. Journal of Geophysical Research–Atmospheres 2005;110(D7):D07S20, doi:10.1029/2004JD004626. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Phuleria HC, Geller MD, Fine PM, Sioutas C. Size-resolved emissions of organic tracers from light- and heavy-duty vehicles measured in a California roadway tunnel. Environmental Science & Technology 2006;40(13):4109-4118. |
R827352 (Final) |
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Prophete C, Maciejczyk P, Salnikow K, Gould T, Larson T, Koenig J, Jaques P, Sioutas C, Lippmann M, Cohen M. Effects of select PM-associated metals on alveolar macrophage phosphorylated ERK1 and -2 and iNOS expression during ongoing alteration in iron homeostasis. Journal of Toxicology and Environmental Health, Part A 2006;69(10):935-951. |
R827352 (Final) R827352C014 (Final) R827351 (Final) R827351C008 (Final) R827351C010 (Final) R827355 (Final) R827355C008 (Final) |
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Reisen F, Wheeler S, Arey J. Methyl-and dimethyl-/ethyl-nitronaphthalenes measured in ambient air in Southern California. Atmospheric Environment 2003;37(26):3653-3657. |
R827352 (2004) R827352 (Final) |
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Reisen F, Arey J. Atmospheric reactions influence seasonal PAH and nitro-PAH concentrations in the Los Angeles Basin. Environmental Science & Technology 2005;39(1):64-73. |
R827352 (Final) |
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Rodriguez CE, Shinyashiki M, Froines J, Yu RC, Fukuto JM, Cho AK. An examination of quinone toxicity using the yeast Saccharomyces cerevisiae model system. Toxicology 2004;201(1-3):185-196. |
R827352 (2004) R827352 (Final) R827352C001 (Final) |
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Rodriguez CE, Fukuto JM, Taguchi K, Froines J, Cho AK. The interactions of 9,10-phenanthrenequinone with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a potential site for toxic actions. Chemico-Biological Interactions 2005;155(1-2):97-110. |
R827352 (Final) R827352C001 (Final) |
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Sardar SB, Fine PM, Yoon H, Sioutas C. Associations between particle number and gaseous co-pollutant concentrations in the Los Angeles Basin. Journal of the Air & Waste Management Association 2004;54(8):992-1005. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Sardar SB, Fine PM, Mayo PR, Sioutas C. Size-fractionated measurements of ambient ultrafine particle chemical composition in Los Angeles using the NanoMOUDI. Environmental Science & Technology 2005;39(4):932-944. |
R827352 (Final) R827352C014 (Final) |
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Sardar SB, Fine PM, Sioutas C. Seasonal and spatial variability of the size-resolved chemical composition of particulate matter (PM10) in the Los Angeles Basin. Journal of Geophysical Research–Atmospheres 2005;110(D7):D07S08,doi:10.1029/2004JD004627 |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Sardar SB, Geller MD, Sioutas C, Solomon PA. Development and evaluation of a high-volume dichotomous sampler for chemical speciation of coarse and fine particles. Journal of Aerosol Science 2006;37(11):1455-1466. |
R827352 (Final) |
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Shen S, Jaques PA, Zhu Y, Geller MD, Sioutas C. Evaluation of the SMPS–APS system as a continuous monitor for measuring PM2.5, PM10 and course (PM2.5–10) concentrations. Atmospheric Environment 2002;36(24):3939-3950. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Singh M, Jaques PA, Sioutas C. Size distribution and diurnal characteristics of particle-bound metals in source and receptor sites of the Los Angeles Basin. Atmospheric Environment 2002;36(10):1675-1689. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Singh M, Misra C, Sioutas C. Field evaluation of a personal cascade impactor sampler (PCIS). Atmospheric Environment 2003;37(34):4781-4793. |
R827352 (Final) R827352C014 (Final) R828678C009 (2002) R828678C009 (2003) R828678C009 (Final) |
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Sioutas C, Kim S, Chang M, Terrell LL, Gong Jr H. Field evaluation of a modified DataRAM MIE scattering monitor for real-time PM2.5 mass concentration measurements. Atmospheric Environment 2000;34(28):4829-4838. |
R827352 (Final) R827352C012 (Final) R827352C014 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Sioutas C, Pandis SN, Allen DT, Solomon PA. Special issue of Atmospheric Environment on findings from EPA’s Particulate Matter Supersites Program. Atmospheric Environment 2004;38(20):3101-3106. |
R827352 (Final) R827352C014 (Final) |
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Sioutas C, Delfino RJ, Singh M. Exposure assessment for atmospheric ultrafine particles (UFPs) and implications in epidemiologic research. Environmental Health Perspectives 2005;113(8):947-955. |
R827352 (Final) R827352C014 (Final) |
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Stolzenburg MR, Dutcher DD, Kirby BW, Hering SV. Automated measurement of the size distribution of airborne particulate nitrate. Aerosol Science and Technology 2003;37(7):537-546. |
R827352 (2004) R827352 (Final) |
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Taguchi K, Fujii S, Yamano S, Cho AK, Kamisuki S, Nakai Y, Sugawara F, Froines JR, Kumagai Y. An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress. Free Radical Biology & Medicine 2007;43(5):789-799. |
R827352 (Final) |
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Venkataraman C, Habib G, Eiguren-Fernandez A, Miguel AH, Friedlander SK. Residential biofuels in South Asia: carbonaceous aerosol emissions and climate impacts. Science 2005;307(5714):1454-1456. |
R827352 (Final) R827352C013 (Final) |
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Westerdahl D, Fruin S, Sax T, Fine PM, Sioutas C. Mobile platform measurements of ultrafine particles and associated pollutant concentrations on freeways and residential streets in Los Angeles. Atmospheric Environment 2005;39(20):3597-3610. |
R827352 (Final) R827352C014 (Final) |
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Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. The Journal of Immunology 2002;168(5):2560-2567. |
R827352 (Final) R827352C002 (Final) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (Final) R826708C002 (Final) R831861 (2004) R831861 (2005) |
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Wilhelm M, Ritz B. Residential proximity to traffic and adverse birth outcomes in Los Angeles County, California, 1994–1996. Environmental Health Perspectives 2003;111(2):207-216. |
R827352 (Final) R827352C008 (Final) |
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Wilhelm M, Ritz B. Local variations in CO and particulate air pollution and adverse birth outcomes in Los Angeles County, California, USA. Environmental Health Perspectives 2005;113(9):1212-1221. |
R827352 (Final) R827352C008 (Final) |
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Wold LE, Simkhovich BZ, Kleinman MT, Nordlie MA, Dow JS, Sioutas C, Kloner RA. In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmias. Cardiovascular Toxicology 2006;6(1):69-78. |
R827352 (Final) R832413 (2008) R832413C001 (2007) |
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Wu J, Lurmann F, Winer A, Lu R, Turco R, Funk TH. Development of an individual exposure model for application to the Southern California Children’s Health Study. Atmospheric Environment 2005;39(2):259-273. |
R827352 (Final) R827352C015 (Final) R828172 (Final) R831845 (2005) R831861 (2004) R831861 (2005) |
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Wu J, Funk T, Lurmann F, Winer A. Improving spatial accuracy of roadway networks and geocoded addresses. Transactions in GIS 2005;9(4):585-601. |
R827352 (Final) R827352C015 (Final) R831845 (2005) R831861 (2005) |
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Xia T, Korge P, Weiss JN, Li N, Venkatesan MI, Sioutas C, Nel A. Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity. Environmental Health Perspectives 2004;112(14):1347-1358. |
R827352 (Final) R827352C002 (Final) R827352C014 (Final) |
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Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Letters 2006;6(8):1794-1807. |
R827352 (Final) R827352C002 (Final) R827352C014 (Final) R832413 (2008) R832413C001 (2007) R832413C001 (2008) R832413C002 (2006) R832413C002 (2008) |
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Yu RC, Teh HW, Jaques PA, Sioutas C, Froines JR. Quality control of semi-continuous mobility size-fractionated particle number concentration data. Atmospheric Environment 2004;38(20):3341-3348. |
R827352 (2004) R827352 (Final) R827352C014 (Final) |
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Zhang KM, Wexler AS, Zhu YF, Hinds WC, Sioutas C. Evolution of particle number distribution near roadways. Part II: The ‘Road-to-Ambient’ process. Atmospheric Environment 2004;38(38):6655-6665. |
R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
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Zhang KM, Wexler AS, Niemeier DA, Zhu YF, Hinds WC, Sioutas C. Evolution of particle number distribution near roadways. Part III: Traffic analysis and on-road size resolved particulate emission factors. Atmospheric Environment 2005;39(22):4155-4166. |
R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
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Zhao Y, Bein KJ, Wexler AS, Misra C, Fine PM, Sioutas C. Field evaluation of the versatile aerosol concentration enrichment system (VACES) particle concentrator coupled to the rapid single-particle mass spectrometer (RSMS-3). Journal of Geophysical Research–Atmospheres 2005;110(D7):D07S02, doi:10.1029/2004JD004644. |
R827352 (Final) R827352C014 (Final) |
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Zhu Y, Hinds WC, Kim S, Sioutas C. Concentration and size distribution of ultrafine particles near a major highway. Journal of the Air & Waste Management Association 2002;52(9):1032-1042. |
R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
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Zhu Y, Hinds WC, Kim S, Shen S, Sioutas C. Study of ultrafine particles near a major highway with heavy-duty diesel traffic. Atmospheric Environment 2002;36(27):4323-4335. |
R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
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Zhu Y, Hinds WC, Shen S, Sioutas C. Seasonal trends of concentration and size distribution of ultrafine particles near major highways in Los Angeles. Aerosol Science and Technology 2004;38(Suppl 1):5-13. |
R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
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Zhu Y, Hinds WC, Krudysz M, Kuhn T, Froines J, Sioutas C. Penetration of freeway ultrafine particles into indoor environments. Journal of Aerosol Science 2005;36(3):303-322. |
R827352 (Final) R827352C006 (Final) R827352C014 (Final) |
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Zhu Y, Hinds WC. Predicting particle number concentrations near a highway based on vertical concentration profile. Atmospheric Environment 2005;39(8):1557-1566. |
R827352 (Final) R827352C006 (Final) |
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Zhu Y, Kuhn T, Mayo P, Hinds WC. Comparison of daytime and nighttime concentration profiles and size distributions of ultrafine particles near a major highway. Environmental Science & Technology 2006;40(8):2531-2536. |
R827352 (Final) R827352C006 (Final) |
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Zhu Y, Yu N, Kuhn T, Hinds WC. Field comparison of P-Trak and condensation particle counters. Aerosol Science and Technology 2006;40(6):422-430. |
R827352 (Final) R827352C006 (Final) |
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Zhu Y, Eiguren-Fernandez A, Hinds WC, Miguel AH. In-cabin commuter exposure to ultrafine particles on Los Angeles freeways. Environmental Science & Technology 2007;41(7):2138-2145. |
R827352 (Final) R832413 (2008) R832413C005 (2007) R832413C005 (2008) |
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Particulate matter, quinones, PAHs, aldehydes, ketones, metals, allergic airway disease, human exposure studies, asthma, cardiovascular effects, aerosol sampling, atmospheric aerosol, environmental monitoring, environmental statistics, California. , Air, Geographic Area, Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, indoor air, Risk Assessments, genetic susceptability, Health Risk Assessment, Children's Health, particulate matter, Environmental Chemistry, State, aerosols, exposure assessment, California (CA), environmentally caused disease, environmental hazard exposures, acute exposure, allergen, health effects, indoor air quality, allergens, outdoor air, particle concentrator, air quality, lead, assessment of exposure, childhood respiratory disease, human health risk, toxics, air toxics, human health effects, particulates, sensitive populations, toxicology, biological response, environmental triggers, air pollution, airway disease, atmospheric chemistry, children, bioaerosols, trajectory modeling, dosimetry, household, inhaled particles, PAH, environmental health hazard, asthma triggers, allergic response, ambient aerosol, asthma, human exposure, Human Health Risk Assessment, PM, particle transport
Progress and Final Reports:
2003 Progress Report
2004 Progress Report
Final Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827352C001 The Chemical Toxicology of Particulate Matter
R827352C002 Pro-inflammatory and the Pro-oxidative Effects of Diesel Exhaust Particulate in Vivo and in Vitro
R827352C003 Measurement of the “Effective” Surface Area of Ultrafine and Accumulation Mode PM (Pilot Project)
R827352C004 Effect of Exposure to Freeways with Heavy Diesel Traffic and Gasoline Traffic on Asthma Mouse Model
R827352C005 Effects of Exposure to Fine and Ultrafine Concentrated Ambient Particles near a Heavily Trafficked Freeway in Geriatric Rats (Pilot Project)
R827352C006 Relationship Between Ultrafine Particle Size Distribution and Distance From Highways
R827352C007 Exposure to Vehicular Pollutants and Respiratory Health
R827352C008 Traffic Density and Human Reproductive Health
R827352C009 The Role of Quinones, Aldehydes, Polycyclic Aromatic Hydrocarbons, and other Atmospheric Transformation Products on Chronic Health Effects in Children
R827352C010 Novel Method for Measurement of Acrolein in Aerosols
R827352C011 Off-Line Sampling of Exhaled Nitric Oxide in Respiratory Health Surveys
R827352C012 Controlled Human Exposure Studies with Concentrated PM
R827352C013 Particle Size Distributions of Polycyclic Aromatic Hydrocarbons in the LAB
R827352C014 Physical and Chemical Characteristics of PM in the LAB (Source Receptor Study)
R827352C015 Exposure Assessment and Airshed Modeling Applications in Support of SCPC and CHS Projects
R827352C016 Particle Dosimetry
R827352C017 Conduct Research and Monitoring That Contributes to a Better Understanding of the Measurement, Sources, Size Distribution, Chemical Composition, Physical State, Spatial and Temporal Variability, and Health Effects of Suspended PM in the Los Angeles Basin (LAB)